論文

査読有り
2018年10月

Association between exercise intensity and renal blood flow evaluated using ultrasound echo

CLINICAL AND EXPERIMENTAL NEPHROLOGY
  • Shotaro Kawakami
  • ,
  • Tetsuhiko Yasuno
  • ,
  • Takuro Matsuda
  • ,
  • Kanta Fujimi
  • ,
  • Ai Ito
  • ,
  • Saki Yoshimura
  • ,
  • Yoshinari Uehara
  • ,
  • Hiroaki Tanaka
  • ,
  • Takao Saito
  • ,
  • Yasuki Higaki

22
5
開始ページ
1061
終了ページ
1068
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s10157-018-1559-1
出版者・発行元
SPRINGER

Background High-intensity exercise reduces renal blood flow (RBF) and may transiently exacerbate renal dysfunction. RBF has previously been measured invasively by administration of an indicator material; however, non-invasive measurement is now possible with technological innovations. This study examined variations in RBF at different exercise intensities using ultrasound echo.Methods Eight healthy men with normal renal function (eGFR(cys) 114 +19 mL/min/1.73 m(2)) participated in this study. Using a bicycle ergometer, participants underwent an incremental exercise test using a ramp protocol (20 W/min) until exhaustion in Study 1 and the lactate acid breaking point (LaBP) was calculated. Participants underwent a multi-stage test at exercise intensities of 60, 80, 100, 120, and 140% LaBP in Study 2. RBF was measured by ultrasound echo at rest and 5 min after exercise in Study 1 and at rest and immediately after each exercise in Study 2. To determine the mechanisms behind RBF decline, a catheter was placed into the antecubital vein to study vasoconstriction dynamics.Results RBF after maximum exercise decreased by 51% in Study 1. In Study 2, RBF showed no significant decrease until 80% LaBP, and showed a significant decrease (31%) at 100% LaBP compared with at rest (p < 0.01). The sympathetic nervous system may be involved in this reduction in RBF.Conclusions RBF showed no significant decrease until 80% LaBP, and decreased with an increase in blood lactate. Reduction in RBF with exercise above the intensity at LaBP was due to decreased cross-sectional area rather than time-averaged flow velocity.

リンク情報
DOI
https://doi.org/10.1007/s10157-018-1559-1
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29525855
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000444813700004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s10157-018-1559-1
  • ISSN : 1342-1751
  • eISSN : 1437-7799
  • PubMed ID : 29525855
  • Web of Science ID : WOS:000444813700004

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