2018年10月
Association between exercise intensity and renal blood flow evaluated using ultrasound echo
CLINICAL AND EXPERIMENTAL NEPHROLOGY
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- 巻
- 22
- 号
- 5
- 開始ページ
- 1061
- 終了ページ
- 1068
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s10157-018-1559-1
- 出版者・発行元
- SPRINGER
Background High-intensity exercise reduces renal blood flow (RBF) and may transiently exacerbate renal dysfunction. RBF has previously been measured invasively by administration of an indicator material; however, non-invasive measurement is now possible with technological innovations. This study examined variations in RBF at different exercise intensities using ultrasound echo.Methods Eight healthy men with normal renal function (eGFR(cys) 114 +19 mL/min/1.73 m(2)) participated in this study. Using a bicycle ergometer, participants underwent an incremental exercise test using a ramp protocol (20 W/min) until exhaustion in Study 1 and the lactate acid breaking point (LaBP) was calculated. Participants underwent a multi-stage test at exercise intensities of 60, 80, 100, 120, and 140% LaBP in Study 2. RBF was measured by ultrasound echo at rest and 5 min after exercise in Study 1 and at rest and immediately after each exercise in Study 2. To determine the mechanisms behind RBF decline, a catheter was placed into the antecubital vein to study vasoconstriction dynamics.Results RBF after maximum exercise decreased by 51% in Study 1. In Study 2, RBF showed no significant decrease until 80% LaBP, and showed a significant decrease (31%) at 100% LaBP compared with at rest (p < 0.01). The sympathetic nervous system may be involved in this reduction in RBF.Conclusions RBF showed no significant decrease until 80% LaBP, and decreased with an increase in blood lactate. Reduction in RBF with exercise above the intensity at LaBP was due to decreased cross-sectional area rather than time-averaged flow velocity.
- リンク情報
- ID情報
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- DOI : 10.1007/s10157-018-1559-1
- ISSN : 1342-1751
- eISSN : 1437-7799
- PubMed ID : 29525855
- Web of Science ID : WOS:000444813700004