2017年
The joint impact of habitual exercise and glycemic control on the incidence of chronic kidney disease (CKD) in middle-aged and older males
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
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- 巻
- 22
- 号
- 1
- 開始ページ
- 76
- 終了ページ
- 76
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1186/s12199-017-0683-y
- 出版者・発行元
- SPRINGER
Background: This retrospective study evaluated the influence of the joint impact of habitual exercise and glycemic control on the incidence of chronic kidney disease (CKD) during a 6-year follow-up period in middle-aged and older males.Methods: The study population included 303 males without a history of cardiovascular disease, stroke, renal dysfunction, or dialysis treatment. Their lifestyle behaviors regarding exercise and physical activity were evaluated using a standardized self-administered questionnaire. The participants were divided into four categories according to the performance or non-performance of habitual exercise and the presence or absence of hyperglycemia.Results: After 6 years, 32 subjects (10.6%) developed CKD (estimated glomerular filtration rate < 60 ml/min/1.73 m(2) and/or proteinuria). The cumulative incidence of CKD was significantly higher among subjects who did not perform habitual exercise and hyperglycemic subjects (log-rank test: p < 0.05, respectively). According to a Cox proportional hazards model, the hazard ratio (HR) for the incidence of CKD in subjects with a normal glucose tolerance (NGT) who did not perform habitual exercise (HR = 2.82, 95% confidence of interval (CI) = 1.07-7. 36, p = 0.034) and that in hyperglycemic subjects who did not perform habitual exercise (HR = 5.89, 95% CI = 1.87-16.63, p = 0.003) were significantly higher in comparison to the subjects with a NGT who performed habitual exercise.Conclusions: These results suggest that the habitual exercise and good glycemic control and their combination were associated with the incidence of CKD.
- リンク情報
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- DOI
- https://doi.org/10.1186/s12199-017-0683-y
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/29165174
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674831
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000423123800001&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1186/s12199-017-0683-y
- ISSN : 1342-078X
- eISSN : 1347-4715
- PubMed ID : 29165174
- PubMed Central 記事ID : PMC5674831
- Web of Science ID : WOS:000423123800001