論文

査読有り
2017年9月

Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis

SCIENTIFIC REPORTS
  • Shoichi Komine
  • ,
  • Kentaro Akiyama
  • ,
  • Eiji Warabi
  • ,
  • Sechang Oh
  • ,
  • Keisuke Kuga
  • ,
  • Kazunori Ishige
  • ,
  • Shinji Togashi
  • ,
  • Toru Yanagawa
  • ,
  • Junichi Shoda

7
1
開始ページ
11977
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-017-12358-8
出版者・発行元
NATURE PUBLISHING GROUP

The failure of Kupffer cells (KCs) to remove endotoxin is an important factor in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). In this study, the effects of exercise training on KC function were studied in terms of in vivo endotoxin clearance and inflammatory responses. Mice were allocated into rest and exercise groups. KC bead phagocytic capacity and plasma steroid hormone levels were determined following exercise training. Endotoxin and inflammatory cytokine levels in plasma were determined over time following endotoxin injection. KC bead phagocytic capacity was potentiated and clearance of exogenously-injected endotoxin was increased in the exercise group. Inflammatory cytokine (TNF-alpha and IL-6) levels were lower in the exercise group. We found that only DHEA was increased in the plasma of the exercise group. In an in vitro experiment, the addition of DHEA to RAW264.7 cells increased bead phagocytic capacity and attenuated endotoxin-induced inflammatory responses. These results suggest that exercise training modulates in vivo endotoxin clearance and inflammatory responses in association with increased DHEA production. These exercise-induced changes in KC capacity may contribute to a slowing of disease progression in NAFLD patients.

Web of Science ® 被引用回数 : 9

リンク情報
DOI
https://doi.org/10.1038/s41598-017-12358-8
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28931917
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000411185100030&DestApp=WOS_CPL

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