論文

査読有り
2018年5月1日

Maturation-associated changes in the non-specific immune response against Flavobacterium psychrophilum in Ayu Plecoglossus altivelis

Fish and Shellfish Immunology
  • Shungo Minami
  • ,
  • Kyuma Suzuki
  • ,
  • Shun Watanabe
  • ,
  • Motohiko Sano
  • ,
  • Goshi Kato

76
開始ページ
167
終了ページ
173
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.fsi.2018.03.005
出版者・発行元
Academic Press

In this study, we investigated maturation-associated changes in non-specific immune responses of ayu against Flavobacterium psychrophilum. The gonadosomatic index was minimum on 16 June, began to increase on 17 July, and reached the maximum value during August. The highest phagocytic rate (16.3%) was observed on 16 June, which decreased significantly to 5.6% on 26 August. The number of viable bacteria after the serum treatment was highest during August, suggesting that bactericidal activity of the serum decreased along with the sexual maturation. Gene expression levels of interleukin-8, and tumor necrosis factor-α in the spleen did not change significantly during this period, whereas the level of suppressor of cytokine signaling (SOCS)3 was significantly higher on 26 August than that on 16 July (p &lt
0.05). These results suggest that phagocytic activity of trunk kidney leukocytes and serum bactericidal activity against F. psychrophilum decreased with sexual maturation, and that SOCS3 may be related to the decrease in non-specific immune activity in ayu.

リンク情報
DOI
https://doi.org/10.1016/j.fsi.2018.03.005
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29510257

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