論文

国際誌
2017年10月26日

High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells.

Scientific reports
  • Satoshi Nakamizo
  • ,
  • Tetsuya Honda
  • ,
  • Akimasa Adachi
  • ,
  • Takahiro Nagatake
  • ,
  • Jun Kunisawa
  • ,
  • Akihiko Kitoh
  • ,
  • Atsushi Otsuka
  • ,
  • Teruki Dainichi
  • ,
  • Takashi Nomura
  • ,
  • Florent Ginhoux
  • ,
  • Koichi Ikuta
  • ,
  • Gyohei Egawa
  • ,
  • Kenji Kabashima

7
1
開始ページ
14076
終了ページ
14076
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-017-14292-1

Psoriasis is a common, chronic inflammatory skin disease characterized by epidermal hyperplasia via the IL-23/IL-17 axis. Various studies have indicated the association between obesity and psoriasis, however, the underlying mechanisms remains unclarified. To this end, we focused on high-fat diet (HFD) in this study, because HFD is suggested as a contributor to obesity, and HFD-fed mice exhibit exacerbated psoriatic dermatitis. Using murine imiquimod (IMQ)-induced psoriasis and HFD-induced obesity models, we have revealed a novel mechanism of HFD-induced exacerbation of psoriatic dermatitis. HFD-fed mice exhibited aggravated psoriatic dermatitis, which was accompanied with increased accumulation of IL-17A-producing Vγ4+ γδ T cells in the skin. HFD also induced the increase of Vγ4+ γδ T cells in other organs such as skin draining lymph nodes, which preceded the increase of them in the skin. In addition, HFD-fed mice displayed increased expression of several γδ T cell-recruiting chemokines in the skin. On the other hand, ob/ob mice, another model of murine obesity on normal diet, did not exhibit aggravated psoriatic dermatitis nor accumulation of γδ T cells in the dermis. These results indicate that HFD is a key element in exacerbation of IMQ-induced psoriatic dermatitis, and further raise the possibility of HFD as a factor that links obesity and psoriasis.

リンク情報
DOI
https://doi.org/10.1038/s41598-017-14292-1
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29074858
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658347
ID情報
  • DOI : 10.1038/s41598-017-14292-1
  • PubMed ID : 29074858
  • PubMed Central 記事ID : PMC5658347

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