論文

査読有り
2019年9月27日

Evaluation of Intensity- and Contour-Based Deformable Image Registration Accuracy in Pancreatic Cancer Patients

Cancers
  • Yoshiki Kubota
  • ,
  • Masahiko Okamoto
  • ,
  • Yang Li
  • ,
  • Shintaro Shiba
  • ,
  • Shohei Okazaki
  • ,
  • Shuichiro Komatsu
  • ,
  • Makoto Sakai
  • ,
  • Nobuteru Kubo
  • ,
  • Tatsuya Ohno
  • ,
  • Takashi Nakano

11
10
開始ページ
1447
終了ページ
1447
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/cancers11101447
出版者・発行元
MDPI AG

We aimed to clarify the accuracy of rigid image registration and deformable image registration (DIR) in carbon-ion radiotherapy (CIRT) for pancreatic cancer. Six patients with pancreatic cancer who were treated with passive irradiation CIRT were enrolled. Three registration patterns were evaluated: treatment planning computed tomography images (TPCT) to CT images acquired in the treatment room (IRCT) in the supine position, TPCT to IRCT in the prone position, and TPCT in the supine position to the prone position. After warping the contours of the original CT images to the destination CT images using deformation matrices from the registration, the warped delineated contours on the destination CT images were compared with the original ones using mean displacement to agreement (MDA). Four contours (clinical target volume (CTV), gross tumor volume (GTV), stomach, duodenum) and four registration algorithms (rigid image registration [RIR], intensity-based DIR [iDIR], contour-based DIR [cDIR], and a hybrid iDIR-cDIR ([hDIR]) were evaluated. The means ± standard deviation of the MDAs of all contours for RIR, iDIR, cDIR, and hDIR were 3.40 ± 3.30, 2.2 1± 2.48, 1.46 ± 1.49, and 1.46 ± 1.37 mm, respectively. There were significant differences between RIR and iDIR, and between RIR/iDIR and cDIR/hDIR. For the pancreatic cancer patient images, cDIR and hDIR had better accuracy than RIR and iDIR.

リンク情報
DOI
https://doi.org/10.3390/cancers11101447
URL
https://www.mdpi.com/2072-6694/11/10/1447/pdf

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