論文

査読有り
2018年2月1日

Assessment of inhalation flow patterns of soft mist inhaler co-prescribed with dry powder inhaler using inspiratory flow meter for multi inhalation devices

PLoS ONE
  • Daiki Hira
  • ,
  • Hiroyoshi Koide
  • ,
  • Shigemi Nakamura
  • ,
  • Toyoko Okada
  • ,
  • Kazunori Ishizeki
  • ,
  • Masafumi Yamaguchi
  • ,
  • Setsuko Koshiyama
  • ,
  • Tetsuya Oguma
  • ,
  • Kayoko Ito
  • ,
  • Saori Funayama
  • ,
  • Yuko Komase
  • ,
  • Shin-Ya Morita
  • ,
  • Kohshi Nishiguchi
  • ,
  • Yasutaka Nakano
  • ,
  • Tomohiro Terada

13
2
開始ページ
e0193082
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0193082
出版者・発行元
Public Library of Science

The patients’ inhalation flow pattern is one of the significant determinants for clinical performance of inhalation therapy. However, the development of inhalation flow meters for various inhalation devices has been unable to keep up with the increasing number of newly launched inhalation devices. In the present study, we developed simple attachment orifices for the inhalation flow pattern monitoring system, which are suitable for all commercial inhalers, and investigated the efficacy of the system on the clinical inhalation instruction for patients co-prescribed dry powder inhaler (DPI) and soft mist inhaler (SMI). First, we constructed simple attachment orifices that were adjusted for 13 commercial inhalers, and examined the correlation between orifice and inhalation device. Second, the inhalation flow patterns (peak inspiratory flow rate, PIFR
inhalation duration time, DT) of patients prescribed a combination of DPI and SMI were monitored before and after inhalation instruction. The inhalation resistance of commercial inhalers are listed in the following order
Twincaps® &gt
Handihaler® &gt
Swinghaler® = Clickhaler® &gt
Twisthaler® &gt
Turbuhaler® &gt
Jenuair® &gt
Diskus® = Ellipta® &gt
Diskhaler® &gt
Breezhaler® &gt
Respimat® = pMDI. The pressure drop via orifice was significantly correlated with that via the commercial inhaler. For the confirmation, all participants achieved the DPI criterion of PIFR. On the other hand, 4 participants (6 clinical visits) of 10 experimented participants could not achieve the essential criterion of DT (&gt
1.5 sec) for SMI, but all participants improved their duration time after inhalation instruction by pharmacists (P&lt
0.05). In the present study, we successfully developed simple attachment orifice suitable for 13 commercial inhalation devices. These data suggested that our simple attachment orifices for the inhalation flow pattern monitoring system can detect patients with inadequate inhalation patterns via SMI.

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0193082
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29462195

エクスポート
BibTeX RIS