Sachiro Kakinoki

Profile Information

Affiliation: Professor, Faculty of Chemistry, Materials and BioengineeringDepartment of Chemistry and Materials Engineering, Kansai University

Degree: 博士（工学）(Mar, 2005)

Researcher number: 70421419
J-GLOBAL ID: 200901067927843655
researchmap Member ID: 5000038618

External link: http://wps.itc.kansai-u.ac.jp/k-sac/

Research Interests

Research Areas

Research History

Apr, 2022 - Present

Professor (Ph.D.), Faculty of Chemistry , Materials and Bioengineering Department of Chemistry and Materials Engineering, Kansai University
Apr, 2015 - Mar, 2022

Associate Professor (Ph.D.), Faculty of Chemistry , Materials and Bioengineering Department of Chemistry and Materials Engineering, Kansai University
Apr, 2010 - Mar, 2015

(独)国立循環器病研究センター研究所生体医工学部研究員（常勤）
Apr, 2007 - Mar, 2010

国立循環器病センター研究所生体工学部流動研究員
Apr, 2006 - Mar, 2007

(独)物質・材料研究機構生体材料センター高次機能生体材料グループ NIMSポスドク研究員
Apr, 2005 - Mar, 2006

(独)物質・材料研究機構生体材料研究センター人工臓器材料グループ特別研究員

Education

Committee Memberships

Apr, 2022 - Present

Editorial Board, Journal of Artificial Organs
Jul, 2021 - Present

Board of Assistant Editors, Journal of Materials Science: Materials in Medicine
May, 2017 - Present

councillor, JAPANESE SOCIETY FOR ARTIFICIAL ORGANS
Apr, 2012 - Present

councillor, Japanese society for biomaterials

Awards

Papers

Microwave-Assisted Incorporation of AgNP into Chitosan–Alginate Hydrogels for Antimicrobial Applications

Takuma Oe, Duangkamol Dechojarassri, Sachiro Kakinoki, Hideya Kawasaki, Tetsuya Furuike, Hiroshi Tamura

Journal of Functional Biomaterials, Apr, 2023
末梢神経再生治療の最前線-基礎から臨床へ- 末梢神経再生デバイスの新たなデザインとその評価法

山岡哲二, 小川興, 徐于懿, 柿木佐知朗, 森本尚樹

日本整形外科学会雑誌, 97(2) S152-S152, Mar, 2023
Stable and direct coating of fibronectin-derived Leu-Asp-Val peptide on ePTFE using one-pot tyrosine oxidation for endothelial cell adhesion

Sachiro Kakinoki, Satoru Nishioka, Yuki Arichi, Tetsuji Yamaoka

Colloids Surf. B, 216, 112576, Aug, 2022 Peer-reviewed
Dynamic in vitro hemocompatibility of oligoproline self-assembled monolayer surfaces

Aldona Mzyk, Gabriela Imbir, Yuri Noguchi, Marek Sanak, Roman Major, Justyna Wiecek, Przemyslaw Kurtyka, Hanna Plutecka, Klaudia Trembecka-Wójciga, Yasuhiko Iwasaki …

Biomaterials Science, 10, 5498-5503, Jul, 2022 Peer-reviewed
Long-lasting hydrophilic surface generated on poly(dimethyl siloxane) with photoreactive zwitterionic polymers.

Hiroki Nakano, Sachiro Kakinoki, Yasuhiko Iwasaki

Colloids and surfaces. B, Biointerfaces, 205 111900-111900, Sep, 2021
A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature

Benjamin Fook Lun Lai, Rick Xing Ze Lu, Locke Davenport Huyer, Sachiro Kakinoki, Joshua Yazbeck, Erika Yan Wang, Qinghua Wu, Boyang Zhang, Milica Radisic

Nature Protocols, 16(4) 2158-2189, Apr, 2021
Effect of Residue Insertion on the Stability of Polyproline-I and II Structures: Circular Dichroism Spectroscopic Analyses of Block-Type Oligo-Prolines (Pro)m-Gly/Ala-(Pro)n

KAKINOKI,Sachiro, KITAMURA, Makoto, NOGUCHI, Yuri, ARICHI, Yuki

Pept. Sci., e24170, Apr 27, 2020 Peer-reviewed
Surfaces immobilized with oligo-prolines prevent protein adsorption and cell adhesion.

Yuri Noguchi, Yasuhiko Iwasaki, Masato Ueda, Sachiro Kakinoki

Journal of materials chemistry. B, 8(11) 2233-2237, Mar 18, 2020 Peer-reviewed
Highly Durable Lubricity of Photo-Cross-Linked Zwitterionic Polymer Brushes Supported by Poly(ether ether ketone) Substrate

Hiroki Nakano, Yuri Noguchi, Sachiro Kakinoki, Mai Yamakawa, Issey Osaka, Yasuhiko Iwasaki

ACS Applied Bio Materials, Jan 10, 2020 Peer-reviewed
Short-term evaluation of thromboresistance of a poly(ether ether ketone) (PEEK) mechanical heart valve with poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-grafted surface in a porcine aortic valve replacement model.

Yusuke Kambe, Atsushi Mahara, Hiroshi Tanaka, Sachiro Kakinoki, Kyoko Fukazawa, Yihua Liu, Masayuki Kyomoto, Kenji Minatoya, Kazuhiko Ishihara, Tetsuji Yamaoka

Journal of biomedical materials research. Part A, 107(5) 1052-1063, May, 2019 Peer-reviewed
Surface modification of porous alpha-tricalcium phosphate granules with heparin enhanced their early osteogenic capability in a rat calvarial defect model.

Yoshihiro Takeda, Yoshitomo Honda, Sachiro Kakinoki, Tetsuji Yamaoka, Shunsuke Baba

Dental materials journal, 37(4) 575-581, Jul 29, 2018 Peer-reviewed
Periodontal regeneration induced by porous alpha-tricalcium phosphate with immobilized basic fibroblast growth factor in a canine model of 2-wall periodontal defects.

Kazuya Matsuse, Yoshiya Hashimoto, Sachiro Kakinoki, Tetsuji Yamaoka, Shosuke Morita

Medical molecular morphology, 51(1) 48-56, Mar, 2018 Peer-reviewed
Direct surface modification of metallic biomaterials via tyrosine oxidation aiming to accelerate the re-endothelialization of vascular stents.

Sachiro Kakinoki, Kensuke Takasaki, Atsushi Mahara, Tomo Ehashi, Yoshiaki Hirano, Tetsuji Yamaoka

Journal of biomedical materials research. Part A, 106(2) 491-499, Feb, 2018 Peer-reviewed
Individual evaluation of cardiac marker expression and self-beating during cardiac differentiation of P19CL6 cells on different culture substrates.

Tetsuji Yamaoka, Mitsuhi Hirata, Takaaki Dan, Atsushi Yamashita, Akihisa Otaka, Takahiko Nakaoki, Azizi Miskon, Sachiro Kakinoki, Atsushi Mahara

Journal of biomedical materials research. Part A, 105(4) 1166-1174, Apr, 2017 Peer-reviewed
Direct surface modification of metallic biomaterials via tyrosine oxidation aiming to accelerate the re-endothelialization of vascular stents

Sachiro Kakinoki, Kensuke Takasaki, Atsushi Mahara, Tomo Ehashi, Yoshiaki Hirano, Tetsuji Yamaoka

J. Biomed. Mat. Res. A, In press, 2017 Peer-reviewed
機能性バイオインターフェイスの新潮流細胞機能制御を指向した分子可動性ポリロタキサン表面の構築

有坂慶紀, 徐知勲, 田村篤志, 柿木佐知朗, 山岡哲二, 由井伸彦

日本バイオマテリアル学会大会予稿集, シンポジウム2016 183-183, Nov, 2016
Dynamic polyrotaxane-coated surface for effective differentiation of mouse induced pluripotent stem cells into cardiomyocytes

Ji-Hun Seo, Mitsuhi Hirata, Sachiro Kakinoki, Tetsuji Yamaoka, Nobuhiko Yui

RSC ADVANCES, 6(42) 35668-35676, 2016
Accelerated tissue integration into porous materials by immobilizing basic fibroblast growth factor using a biologically safe three-step reaction.

Sachiro Kakinoki, Yusuke Sakai, Toshia Fujisato, Tetsuji Yamaoka

Journal of biomedical materials research. Part A, 103(12) 3790-7, Dec, 2015 Peer-reviewed
Single-step immobilization of cell adhesive peptides on a variety of biomaterial substrates via tyrosine oxidation with copper catalyst and hydrogen peroxide.

Sachiro Kakinoki, Tetsuji Yamaoka

Bioconjugate chemistry, 26(4) 639-44, Apr 15, 2015 Peer-reviewed
Mobility of the Arg-Gly-Asp ligand on the outermost surface of biomaterials suppresses integrin-mediated mechanotransduction and subsequent cell functions.

Sachiro Kakinoki, Ji-Hun Seo, Yuuki Inoue, Kazuhiko Ishihara, Nobuhiko Yui, Tetsuji Yamaoka

Acta biomaterialia, 13 42-51, Feb, 2015 Peer-reviewed

Misc.

Effect of dynamic polyrotaxane coating on cytoskeletal signaling expression of adhering stem cells and downstream differentiations.

Ji Hun Seo, Mitsuhi Hirata, Sachiro Kakinoki, Tetsuji Yamaoka, Nobuhiko Yui

Advances in Science and Technology, 102 37-42, Jan, 2017 Peer-reviewed
抗血栓性処理PEEK製機械弁の創出とワーファリンフリー生涯型弁への挑戦

神戸裕介, 田中裕史, 馬原淳, 深澤今日子, 塩島太郎, ムニッソマリアキアラ, 柿木佐知朗, 染川将太, 村越成恵, 徳重恭之 …

高分子学会医用高分子シンポジウム講演要旨集, 45th, 2016
Electrospun Micro-Fibrous Conduits Composed of Poly(l-lactic Acid) and Elastin-Laminin Mimicking Protein for Peripheral Nerve Regeneration

S. Kakinoki, M. Nakayama, T. Moritan, T. Yamaoka

TISSUE ENGINEERING PART A, 20 S3-S3, Dec, 2014
ePTFEへのフィブロネクチン由来ペプチドの固定化と内皮細胞接着性の向上

柿木佐知朗, 馬原淳, 山岡哲二

人工臓器(日本人工臓器学会), 43(2), 2014
REDV-Bearing Stent : One Step Immobilization of Tyr Containing Peptides onto Biomaterial Surfaces

KAKINOKI Sachiro, TAKASAKI Kensuke, HIRANO Yoshiaki, YAMAOKA Tetsuji

2012 109-110, Mar 1, 2013
Surface Modification of Fiber Scaffolds for Regenerative Medicine

Tetsuji Yamaoka, Sachiro Kakinoki

SEN-I GAKKAISHI, 68(11) 314-318, Nov, 2012
人工細胞外基質よりなる神経誘導管を用いた末梢神経再生

柿木佐知朗

人工臓器, 41(1) 53-54, Jun 15, 2012
Biological responses on the dynamic surfaces prepared by supramolecular block copolymers

Ji-Hun Seo, Sachiro Kakinoki, Tetsuji Yamaoka, Nobuhiko Yui

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 243, Mar, 2012
高分子多孔質スキャホールドの埋入が誘起する炎症反応の遺伝子網羅的解析

柿木佐知朗, 柿木佐知朗, 坂井勇亮, 坂井勇亮, 竹村太郎, 花方信孝, 藤里俊哉, 石原一彦, 石原一彦, 山岡哲二 …

人工臓器(日本人工臓器学会), 41(2), 2012
Society for Biomaterials 2011 Annual Meeting & Exposition に参加して

柿木佐知朗

人工臓器, 40(3) 261-262, Dec 15, 2011
Development of novel stents

KAKINOKI Sachiro, YAMAOKA Tetsuji

Journal of Japanese Society for Biomaterials, 29(3) 166-173, Aug 4, 2011
Construction of elastin-like peptide expression vector using BbsI restriction enzyme for neural regeneration

KAKINOKI Sachiro, YAMAOKA Tetsuji

Peptide Science (Proceedings of the Fifth International Peptide Symposium), 2010 279-279, Mar 1, 2011
Modification of PLA Scaffolds Using Bioactive Peptide-Oligo (Lactic Acid) Conjugates

KAKINOKI Sachiro, UCHIDA Sho, EHASHI Tomo, MURAKAMI Akira, YAMAOKA Tetsuji

2008 449-450, Mar 1, 2009
Conformational Transition of Poly(proline) in Various Solvents

YUGE Mitsuhiro, KAKINOKI Sachiro, HIRANO Yoshiaki, OKA Masahito

2006 84-85, Mar 1, 2007
Conformation Analysis of Proline-Rich Block Copolypeptides

YUGE Mitsuhiro, KAKINOKI Sachiro, KAWAGUCHI Takuya, HIRANO Yoshiaki, OKA Masahito

2006 86-87, Mar 1, 2007
Chain-Length Dependence of Conformational Property of Poly(proline)

YUGE Mitsuhiro, KAKINOKI Sachiro, KITAMURA Makoto, HIRANO Yoshiaki, OKA Masahito

2006 82-83, Mar 1, 2007
高親水性高分子を用いた人工血管用スキャホールドの作製と評価

佐々木愛, 柿木佐知朗, 馬原淳, 中谷武嗣, 山岡哲二

日本バイオマテリアル学会大会予稿集, 29th, 2007
体に優しい医療用接着剤

柿木佐知朗, 田口哲志

ケミカルエンジニヤリング, 51(7) 555-560, Jul, 2006
The injectable drug delivery system for anticancer chemotherapy using the novel tissue adhesive: Characterization and in vitro evaluation

S Kakinoki, T Taguchi, H Kobayashi, J Tanaka

TISSUE ENGINEERING, 12(4) 1077-1077, Apr, 2006
Synthesis of novel crosslinkers for promoting spheroid formation

M Ito, T Taguchi, S Kakinoki, H Kobayashi, J Tanaka

TISSUE ENGINEERING, 12(4) 1078-1078, Apr, 2006

Books and Other Publications

人工臓器の終わりなき挑戦（３）免疫応答・炎症反応、さらに生体適合の謎に迫る

柿木佐知朗

人工臓器は、いま, 2013
バイオロジカルスキャホールドと脱細胞組織

山岡哲二, 柿木佐知朗, 馬原淳 (Role: Joint author)

再生医療叢書【2】組織工学, 2013
神経

柿木佐知朗, 山岡哲二 (Role: Joint author)

再生医療における臨床研究と製品開発, 2013
免疫と炎症

柿木佐知朗, 山岡哲二 (Role: Joint author)

先端バイオマテリアルハンドブック, 2012
再生医療のための繊維材料修飾とその評価

山岡哲二, 柿木佐知朗 (Role: Joint author)

繊維と工業, 2012
ステント（3）：ステントの新展開

柿木佐知朗, 山岡哲二 (Role: Joint author)

バイオマテリアル-生体材料, 2011
体に優しい医療用接着剤

柿木佐知朗, 田口哲志 (Role: Joint author)

ケミカルエンジニアリング, 2006

Presentations

Single step immobilization of REDV peptide onto a variety of biomaterial substrates by tyrosine oxidation

Sachiro Kakinoki, Tetsuji Yamaoka

2014 Annual meeting & exposition of Society for Biomaterials, Apr 16, 2014
Single step peptide immobilization technique onto a variety of biomaterial surfaces by Tyr oxidation and its application for re-endothelialization promoting vascular stent

Sachiro Kakinoki, Kensuke Takasaki, Yoshiaki Hirano, Tetsuji Yamaoka

ICBME2013, Dec 4, 2013
Biomaterial functionalization by single step peptide immobilization via Tyr oxidation

Sachiro Kakinoki, Kensuke Takasaki, Yoshiaki Hirano, Tetsuji Yamaoka

AMWC2013, Sep 15, 2013
Direct immobilization of cell adhesive peptide onto various substrates using tyrosine oxidation

Sachiro Kakinoki, Kensuke Takasaki, Yoshiaki Hirano, Tetsuji Yamaoka

XXXX ESAO, Sep 11, 2013
eptide functionalization of intravascular stent surface via oxidation reaction for promoting in situ re-endothelialization

Sachiro Kakinoki, Kensuke Takasaki, Yoshiaki Hirano, Tetsuji Yamaoka

20th Meeting of the Korea society for biomaterials, Dec 15, 2012
Non-specific Cellular Responses to the Mobile Surfaces with Polyrotaxane

Sachiro Kakinoki, Ji-Hun Seo, Kazuhiko Ishihara, Nobuhiko Yui, Tetsuji Yamaoka

International conference of young researchers on advanced materials, Jul 5, 2012
Global Gene Expression Analysis of Biological Responses to the Porous Scaffolds with Different Surfaces

Sachiro Kakinoki, Yusuke Sakai, Tomo Ehashi, Taro Takemura, Nobutaka Hanagata, Toshia Fujisato, Kazuhiko Ishihara, Nobuhiko Yui, Tetsuji Yamaoka

9th World Biomaterials Congress, Jun 4, 2012
Non-specific and Specific Cellular Responses on the Supramolecular Bio-interface with Mobile Substances

Sachiro Kakinoki, Ji-Hun Seo, Atsushi Yamashita, Kazuhiko Ishihara, Nobuhiko Yui, Tetsuji Yamaoka

9th World Biomaterials Congress, Jun 4, 2012
Protein adsorption and cell adhesion onto PEG-immobilized surfaces with graft and loop structures

Takuya Nakagoshi, Sachiro Kakinoki, Yuichi Ohya, Tetsuji Yamaoka

Softinterface international mini-symposium on biointerface (SIMS2012), Mar 19, 2012
In vivo re-endothelialization of the REDV peptide-immobilized metal surface

Sachiro Kakinoki, Kensuke Takasaki, Yoshiaki Hirano, Tetsuji Yamaoka

International Conference on Nanomaterials & nanotechnology (ICNANO2011), Dec 20, 2011
Platelet response to PEG-grafted biomaterial surfaces with different chain length and molecular architecture

Sachiro Kakinoki, Takuya Nakagoshi, Yuuki Inoue, Lin Ye, Yuichi Ohya, Kazuhiko Ishihara, Nobuhiko Yui, Tetsuji Yamaoka

The 3rd Asian Biomaterials Congress, Sep 15, 2011
REDV peptide-immobilized surface for enhanced endotheliarization

Sachiro Kakinoki, Kensuke Takasaki, Yoshiaki Hirano, Tetsuji Yamaoka

The 3rd Asian Biomaterials Congress, Sep 15, 2011
Thermo-responsive artificial extracellular matrix protein for nerve regeneration

Sachiro Kakinoki, Tetsuji Yamaoka

2011 Annual Meeting&Exposition of society for biomaterials, Apr 14, 2011
Platelet response to PEG-modified surface with different molecular architecture

Sachiro Kakinoki, Lin Ye, Yuuki Inoue, Kazuhiko Ishihara, Nobuhiko Yui, Tetsuji Yamaoka

2011 Annual Meeting&Exposition of society for biomaterials, Apr 14, 2011
Cell adhesion and tissue regeneration on poly(lactic acid) -based scaffolds modified with oligo(lactic acid) -oligo peptide amphiphilic conjugates

Sachiro Kakinoki, Tetsuji Yamaoka

5th International peptide symposium, Dec 4, 2010
Cell adhesion and tissue regeneration on poly(lactic acid) -based scaffolds modified with oligo(lactic acid) -oligo peptide amphiphilic conjugates

Sachiro Kakinoki, Tetsuji Yamaoka

5th International peptide symposium, Dec 4, 2010
Bioactive interface composed of ECM-like peptides on PLA scaffolds for nerve regeneration

Sachiro Kakinoki, Tetsuji Yamaoka

International Symposium on Nanobio-interfaces Related to Molecular Mobility, Nov 9, 2009
Biosynthesis of thermoresponsive artificial ECM composed of elastin-like repetitive sequence (VPGIG)n and the laminin-derived sequence

Sachiro Kakinoki, Tetsuji Yamaoka

8th International Symposium on Frontiers in Biomedical Polymers, May 20, 2009
Fundamental Studies of Artificial Extra Cellular Matrix Composed of Laminin-derived sequence

Sachiro Kakinoki, Kaori Hiraku, Alyssa Panitch, David A. Tirrell, Tetsuji Yamaoka

The TERMIS North America 2008 Annual Conference & Exposition, Dec 9, 2008
Fundamental Studies of Genetically Engineered Elastin Model Peptide for Scaffold Biomaterials

Sachiro Kakinoki, Wakako Kamata, Alyssa Panitch, David A. Tirrell, Tetsuji Yamaoka

1st Asia Biomaterial Congress, Dec 6, 2007

Professional Memberships

Research Projects

Development of extracorporeal VAD housing having excellent blood compatibility using anti-fouling peptide immobilization technology

Grants-in-Aid for Scientific Research, Fund for the Promotion of Joint International Research (International Collaborative Research), Japan Society for the Promotion of Science, Sep, 2023 - Mar, 2027
Investigation of stenosis-preventive effect of bifunctionalized artificial blood vessels using peptide modification technology

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2026
医用材料に吸着する超微量タンパク質の高感度絶対定量法の開発

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2018 - Mar, 2021

加藤愛, 柿木佐知朗
Development of ePTFE graft having both anti-thrombogenicity and regeneration capacity of tunica intima

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

KAKINOKI Sachiro
Treatment of rat myocardial infarction by injecting thermoresponsive and biodegradable hydrogel with various properties

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Nakatani Takeshi, YAMAOKA Tetsuji, KAKINOKI Sachiro, JYO Yui
In vivo evaluation of immune responses and inflammation against biomaterials by global gene analysis

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

KAKINOKI Sachiro
アミノ酸を用いた金属系生体材料の表面修飾方法の開発

科学研究費助成事業若手研究(B), 若手研究(B), 日本学術振興会, 2007 - 2007

柿木佐知朗
Development of high-functional biomaterials by using peptide-protein engineering

2007
周期性ポリペプチドの構造解析とその応用に関する研究

科学研究費補助金, 2002 - 2005
Study on conformation, molecular propaties and application of repetitive polypeptides

Grant-in-Aid for Scientific Research, 2002 - 2005

Industrial Property Rights

特許6202669 ペプチド及びその複合体、組織修復用スキャフォールド及びその表面処理方法、並びに表面処理液又は処理液のセット
特開2017-023008 ポリロタキサンブロック共重合体表面を有する培養器を用いた幹細胞の培養方法
特許6041132 材料表面修飾方法

柿木佐知朗
特許5297632 血液凝固抑制材料並びにそれを用いたコーティング材料及び生体留置部材

山岡哲二, 加藤聡, 笠井厚, 柿木佐知朗
特開2008-127330 複合材料とその製造方法

田口哲志, 柿木佐知朗
特開2007-325824 局所投与型化学療法用材料

田口哲志, 柿木佐知朗
特開2007-111300 局所投与型徐放性生体内分解吸収性医用材料

田口哲志, 柿木佐知朗, 田中順三
特開2006-346049 固−液混合型二成分系生体内分解吸収性粘着性医用材料

田口哲志, 柿木佐知朗, 田中順三, 斉藤浩史

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Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Papers

Misc.

Books and Other Publications

Presentations

Professional Memberships

Research Projects

Industrial Property Rights

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