Tomohiko Fukuda

Profile Information

Affiliation: 准教授, 薬学部, 東北医科薬科大学

Degree: 博士（農学）(大阪府立大学)

J-GLOBAL ID: 201201073454576315
researchmap Member ID: B000222393

External link: https://nrid.nii.ac.jp/nrid/1000040433510/

N-結合型糖鎖の根本にalpha 1,6-fucose を転移する酵素Fut8 を欠損させたマウスの行動解析から、ヒト精神疾患の症状を反映した行動をみいだし、病態に深く関与すると考えられている脳内モノアミンのバランスが崩れていることを見出しました。現在、その分子メカニズムを明らかにしようと奮闘中です。

Research Interests

Research Areas

Research History

Apr, 2012 - Present

Tohoku Medical and Pharmaceutical University
Apr, 2012 - Mar, 2016

東北薬科大学
2009 - 2012

講師, 東北薬科大学薬学部

Papers

BRCC36 associates with FLT3-ITD to regulate its protein stability and intracellular signaling in acute myeloid leukemia.

Jianwei Liu, Tomoya Isaji, Sachiko Komatsu, Yuhan Sun, Xing Xu, Tomohiko Fukuda, Tsutomu Fujimura, Shinichiro Takahashi, Jianguo Gu

Cancer science, Jan 30, 2024
Core fucosylation regulates the ovarian response via FSH receptor during follicular development.

Tiantong Wang, Zhiwei Zhang, Changduo Qu, Wanli Song, Ming Li, Xiaoguang Shao, Tomohiko Fukuda, Jianguo Gu, Naoyuki Taniguchi, Wenzhe Li

Journal of advanced research, Jan 26, 2024
Exogenous L-fucose attenuates neuroinflammation induced by lipopolysaccharide.

Xing Xu, Tomohiko Fukuda, Jun Takai, Sayaka Morii, Yuhan Sun, Jianwei Liu, Shiho Ohno, Tomoya Isaji, Yoshiki Yamaguchi, Miyako Nakano …

The Journal of biological chemistry, 105513-105513, Nov 30, 2023
A highly specific antibody against the core fucose of the N-glycan in IgG identifies the pulmonary diseases and its regulation by CCL2.

Noriko Kanto, Yuki Ohkawa, Masato Kitano, Kento Maeda, Masafumi Shiida, Tatsuya Ono, Fumi Ota, Yasuhiko Kizuka, Kei Kunimasa, Kazumi Nishino …

The Journal of biological chemistry, 299(12) 105365-105365, Oct 19, 2023
Focal-adhesion kinase regulates the sialylation of N-glycans via the PI4KIIα-PI4P pathway.

Yuhan Sun, Tomoya Isaji, Yoshiyuki Oyama, Xing Xu, Jianwei Liu, Hisatoshi Hanamatsu, Ikuko Yokota, Nobuaki Miura, Jun-Ichi Furukawa, Tomohiko Fukuda …

The Journal of biological chemistry, 105051-105051, Jul 12, 2023
Expression of GnT-III decreases chemoresistance via negatively regulating P-glycoprotein expression: Involvement of the TNFR2-NF-κB signaling pathway.

Wanli Song, Caixia Liang, Yuhan Sun, Sayaka Morii, Shin Yomogida, Tomoya Isaji, Tomohiko Fukuda, Qinglei Hang, Akiyoshi Hara, Miyako Nakano …

The Journal of biological chemistry, 299(4) 103051-103051, Feb 21, 2023
α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish

Nozomi Hayashiji, Genri Kawahara, Xing Xu, Tomohiko Fukuda, Aurelien Kerever, Jianguo Gu, Yukiko K. Hayashi, Eri Arikawa-Hirasawa

Cells, 12(1) 144-144, Dec 29, 2022
The ulcerative colitis-associated gene FUT8 regulates the quantity and quality of secreted mucins.

Gerard Cantero-Recasens, Carla Burballa, Yuki Ohkawa, Tomohiko Fukuda, Yoichiro Harada, Amy J Curwin, Nathalie Brouwers, Gian A Thun, Jianguo Gu, Ivo Gut …

Proceedings of the National Academy of Sciences of the United States of America, 119(43) e2205277119, Oct 25, 2022
株化筋芽細胞C2C12を用いた糖鎖修飾因子Fut8が筋分化に与える影響

林地のぞみ, 川原玄理, 福田友彦, 顧建国, 林由起子, 平澤恵理

日本筋学会学術集会プログラム・抄録集, 8回 121-121, Aug, 2022
O-GlcNAcylation regulates β1,4-GlcNAc-branched N-glycan biosynthesis via the OGT/SLC35A3/GnT-IV axis.

Wanli Song, Tomoya Isaji, Miyako Nakano, Caixia Liang, Tomohiko Fukuda, Jianguo Gu

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36(2) e22149, Feb, 2022
α1,6-Fucosyltransferase contributes to cell migration and proliferation as well as to cancer stemness features in pancreatic carcinoma.

Caixia Liang, Tomohiko Fukuda, Tomoya Isaji, Chengwei Duan, Wanli Song, Yuqin Wang, Jianguo Gu

Biochimica et biophysica acta. General subjects, 1865(6) 129870-129870, Feb 9, 2021
Loss of core fucosylation enhances the anticancer activity of cytotoxic T lymphocytes by increasing PD-1 degradation.

Nianzhu Zhang, Ming Li, Xing Xu, Yingshu Zhang, Yancheng Liu, Meng Zhao, Peng Li, Jun Chen, Tomohiko Fukuda, Jianguo Gu …

European journal of immunology, 50(11) 1820-1833, Nov, 2020 Peer-reviewed
Identification of the minimal N-glycosylation on integrin α5β1 required for its inhibitory effect on EGFR signaling and cell proliferation.

Sicong Hou, Qinglei Hang, Tomoya Isaji, Tomohiko Fukuda, Jianguo Gu

Biochemical and biophysical research communications, 523(1) 226-232, Feb 26, 2020 Peer-reviewed
EpCAM associates with integrin and regulates cell adhesion in cancer cells.

Jie Yang, Tomoya Isaji, Guowei Zhang, Feng Qi, Chengwei Duan, Tomohiko Fukuda, Jianguo Gu

Biochemical and biophysical research communications, 522(4) 903-909, Feb 19, 2020 Peer-reviewed
Deficiency of core fucosylation activates cellular signaling dependent on FLT3 expression in a Ba/F3 cell system.

Chengwei Duan, Tomohiko Fukuda, Tomoya Isaji, Feng Qi, Jie Yang, Yuqin Wang, Shinichiro Takahashi, Jianguo Gu

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(2) 3239-3252, Feb, 2020 Peer-reviewed
Core Fucosylation of Intestinal Epithelial Cells Protects Against Salmonella Typhi Infection via Up-Regulating the Biological Antagonism of Intestinal Microbiota.

Sijia Hao, Qingjie Fan, Yaqiang Bai, Hui Fang, Jiaorui Zhou, Tomohiko Fukuda, Jianguo Gu, Ming Li, Wenzhe Li

Frontiers in microbiology, 11 1097-1097, 2020 Peer-reviewed
ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3-sialylation of target proteins.

Feng Qi, Tomoya Isaji, Chengwei Duan, Jie Yang, Yuqin Wang, Tomohiko Fukuda, Jianguo Gu

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(1) 881-897, Jan, 2020 Peer-reviewed
A complex between phosphatidylinositol 4-kinase IIα and integrin α3β1 is required for N-glycan sialylation in cancer cells.

Tomoya Isaji, Sanghun Im, Akihiko Kameyama, Yuqin Wang, Tomohiko Fukuda, Jianguo Gu

The Journal of biological chemistry, 294(12) 4425-4436, Mar 22, 2019 Peer-reviewed
Deficiency of α1,6-fucosyltransferase promotes neuroinflammation by increasing the sensitivity of glial cells to inflammatory mediators.

Xu Lu, Dongmei Zhang, Hayato Shoji, Chengwei Duan, Guowei Zhang, Tomoya Isaji, Yuqin Wang, Tomohiko Fukuda, Jianguo Gu

Biochimica et biophysica acta. General subjects, 1863(3) 598-608, Mar, 2019 Peer-reviewed
O-GlcNAcylation regulates integrin-mediated cell adhesion and migration via formation of focal adhesion complexes.

Zhiwei Xu, Tomoya Isaji, Tomohiko Fukuda, Yuqin Wang, Jianguo Gu

The Journal of biological chemistry, 294(9) 3117-3124, Mar 1, 2019 Peer-reviewed

Misc.

コアフコシル化を欠損した肝細胞由来の細胞外小胞では、インテグリンα3β1が増加した

新居瞳, 鎌田佳宏, 赤松佑香, 前田恵, 福田友彦, 顧建国, 三善英知

日本癌学会総会記事, 76回 P-1167, Sep, 2017
Functional analysis of the expression of N-glycans in epithelial-mesenchymal transition: Importance of alpha 2,6 sialylation

Jianguo Gu, Jishun Lu, Sanghun Im, Tomohiko Fukuda, Noritaka Hashii, Daisuke Takakura, Nana Kawasaki, Tomoya Isaji

GLYCOBIOLOGY, 24(11) 1177-1177, Nov, 2014
GOLPH3 regulates integrin-mediated biological functions via up-regulation of sialylation

Tomoya Isaji, Sanghun Im, Tomohiko Fukuda, Jianguo Gu

GLYCOBIOLOGY, 23(11) 1336-1336, Nov, 2013
【第三の生命鎖糖鎖の機能と疾患がん、糖尿病、筋ジストロフィー発症との関わりからマーカー・合成法の開発、技術革新まで】(第1章)作動原理と疾患、生命現象とのかかわり神経 α1,6フコース転移酵素欠損マウスにみられた統合失調症様行動とその解析

顧建国, 谷口直之, 福田友彦

実験医学, 31(10) 1502-1507, Jun, 2013
α1,6フコース転移酵素Fut8欠損による海馬機能の変化

福田友彦, GU Wei, 橋本弘和, 酒井誠一郎, WANG Yiu Qing, 伊左治知弥, 八尾寛, 東秀好, GU Jianguo

日本糖質学会年会要旨集, 31st 123, Aug 31, 2012
【糖鎖と神経疾患】N型糖鎖 α1,6フコース欠損マウスと統合失調症様行動

福田友彦, 谷口直之, 顧建国

脳21, 14(1) 26-31, Jan, 2011
N-Glycosylation on I-Like Domain of beta1 Integrin is Essential for its Expression and Biological Functions

Tomoya Isaji, Yuya Sato, Tomohiko Fukuda, Jianguo Gu

GLYCOBIOLOGY, 18(11) 991-991, Nov, 2008
A Mutual Regulation Between Cell-cell Adhesion and GnT-III Expression

Yuya Sato, Yoshinobu Kariya, Tomoya Isaji, Tomohiko Fukuda, Naoyuki Taniguchi, Jianguo Gu

GLYCOBIOLOGY, 18(11) 988-989, Nov, 2008
インテグリン連関キナーゼ

福田友彦, 関口清俊

生体の科学, 55(5) 432-433, Oct, 2004 Invited
Integrin-linked kinase

福田友彦, 関口清俊

生体の科学, 51(6) 614-616, Jun, 2000
フィブロネクチンと疾患

福田友彦, 関口清俊

病理と臨床, 18(4) 358-363, Apr, 2000

Research Projects

糖転移酵素GnT-IIIによるがんの薬剤耐性の制御とその分子機序の解明

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2023 - Mar, 2027

顧建国, 亀岡淳一, 高橋伸一郎, 福田友彦, 伊左治知弥
Elucidation of molecular mechanism for IgG levels regulated by L-fucose

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2022 - Mar, 2025
Elucidation of neuroinflammation and brain function control mechanism by alpha1,6 fucose

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Functions of glycosylation in integrin-mediated outside-in and inside-out signaling

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2023
Role of alpha1,6-fucosyltransferase Fut8 in neuron-glia interactions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Fukuda Tomohiko
Analysis of sialylation on cell biological functions

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2019

GU Jianguo, ISAJI Tomoya, FUKUDA Tomohiko
Anticancer effects based on core fucose

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

GU Jianguo, FUKUDA Tomohiko
The role of SIRT6 protein in gynecologic cancer.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Miyamoto Yuichiro, SAKURABASHI Ayako, FUKUDA Tomohiko
Functional analysis of alpha1,6-fucosyltransferase deficient mice and underlying molecular mechanism

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

FUKUDA Tomohiko
Change of oligosaccharides in cell adhesion, and its roles

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2009 - Mar, 2014

GU Jianguo, FUKUDA Tomohiko, ISAJI Tomoya
Liver regeneration is dependent on sugar chain

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2011 - 2013

GU Jianguo, FUKUDA Tomohiko
脳神経系におけるα1,6フコース構造の役割

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, 2010 - 2011

福田友彦, 顧建国
N-結合型糖鎖によるラミニン-5の機能制御

科学研究費助成事業若手研究(スタートアップ), 若手研究(スタートアップ), 日本学術振興会, 2006 - 2007

福田友彦
細胞外マトリックスを標的とした新しいバイオターゲティング技術の開発とその応用

科学研究費助成事業特定領域研究(A), 特定領域研究(A), 日本学術振興会, 1998 - 1998

関口清俊, 福田友彦, 眞鍋理一郎, 李紹良
選択的スプライシングによるフィブロネクチンの活性化と癌細胞増殖制御

科学研究費助成事業特定領域研究(A), 特定領域研究(A), 日本学術振興会, 1998 - 1998

関口清俊, 福田友彦, 真鍋理一郎, 李紹良
部位特異的変異導入法によるフィブロネクチンの複合ドメイン構造の生理的意義の解明

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 1998 - 1998

福田友彦
フィブロネクチンの自己会合ドメインを利用した新機能細胞外超構造の構築

科学研究費助成事業重点領域研究, 重点領域研究, 日本学術振興会, 1997 - 1997

関口清俊, 福田友彦, 眞鍋理一郎

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