論文

国際誌
2017年

Effect of Lymphodepletion on Donor T Cells and the Role of Recipient Cells Persisting after Cytotoxic Treatments in Cancer Immunotherapies.

Critical reviews in immunology
  • Satoshi Watanabe
  • ,
  • Masashi Arita
  • ,
  • Miho Takahashi
  • ,
  • Yu Saida
  • ,
  • Toshiyuki Koya
  • ,
  • Toshiaki Kikuchi

37
1
開始ページ
59
終了ページ
73
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1615/CritRevImmunol.2018019497

The effectiveness of lymphodepletion in antitumor immunity has been well established. Although recent studies have elucidated some of the broad mechanisms underlying the augmentation of antitumor immunity by lymphodepletion, such as increased availability of cytokines due to the elimination of cellular elements and improvement in tumor antigen presentation, the precise mechanisms remain unclear. Previous studies have focused on the enhancement of the functions of transferred antitumor CD8+ T cells after lymphodepletion. In this review, we discuss the important role of other immune cells in the effectiveness of lymphodepletion. Recent studies have demonstrated that lymphodepletion enhances not only transferred tumor-specific CD8+ T cells but also tumor-specific CD4+ T cells and polyclonal naïve T cells. Moreover, recipient immune cells, including CD8+ T cells, regulatory T cells, dendritic cells, and macrophages, are involved in the augmentation of antitumor effects by lymphodepletion. These host cells can survive lymphodepletive therapies and play a role in the development of antitumor immunity after lymphodepletion. Improvements in the understanding of lymphodepletion allow us to design effective cancer immunotherapy.

リンク情報
DOI
https://doi.org/10.1615/CritRevImmunol.2018019497
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29431079
ID情報
  • DOI : 10.1615/CritRevImmunol.2018019497
  • PubMed ID : 29431079

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