齊藤公亮 (Kosuke Saito) - マイポータル

基本情報

所属: 厚生労働省国立医薬品食品衛生研究所

J-GLOBAL ID: 201801015181592430
researchmap会員ID: B000309549

研究分野

ライフサイエンス / 薬系分析、物理化学 /

論文

Identification and Characterization of Three Novel Biomarkers for Mixed/Cholestatic Drug-Induced Liver Injury.

Kosuke Saito, Tatehiro Kagawa, Keiji Tsuji, Yuji Kumagai, Ken Sato, Shotaro Sakisaka, Naoya Sakamoto, Mitsuhiko Aiso, Shunji Hirose, Nami Mori …

Hepatology research : the official journal of the Japan Society of Hepatology 2025年9月29日
Optimizing linker rigidity to improve intracellular behavior of PROTACs targeting hematopoietic prostaglandin D synthase.

Hinata Osawa, Kosuke Saito, Yosuke Demizu

RSC medicinal chemistry 2025年9月2日
Comprehensive invitro evaluation of the inhibitory effects of relatively high molecular weight peptides on drug-drug interaction-associated four liver transporters and its association with physicochemical properties.

Rika Ishikawa, Takashi Misawa, Yosuke Demizu, Yoshiro Saito, Ruri Kikura-Hanajiri, Kosuke Saito

Drug metabolism and pharmacokinetics 61 101055-101055 2025年4月
Lipidomic profiling of plasma from patients with multiple myeloma receiving bortezomib: an exploratory biomarker study of JCOG1105 (JCOG1105A1).

Masaki Ri, Shinsuke Iida, Kosuke Saito, Yoshiro Saito, Dai Maruyama, Arisa Asano, Suguru Fukuhara, Hideki Tsujimura, Kana Miyazaki, Shuichi Ota …

Cancer chemotherapy and pharmacology 95(1) 29-29 2025年1月24日
Relationship Between the Lipidome Profile and Disease Activity in Patients with Rheumatoid Arthritis.

Shotaro Masuoka, Junko Nishio, Soichi Yamada, Kosuke Saito, Kaichi Kaneko, Makoto Kaburaki, Nahoko Tanaka, Hiroshi Sato, Sei Muraoka, Mai Kawazoe …

Inflammation 47(4) 1444-1458 2024年8月
Interlaboratory evaluation of LC-MS-based biomarker assays.

Kosuke Saito, Ryoya Goda, Koji Arai, Kota Asahina, Mitsuhiko Kawabata, Hitoshi Uchiyama, Tomohiro Andou, Hisao Shimizu, Kentaro Takahara, Masaaki Kakehi …

Bioanalysis 16(6) 389-402 2024年3月
Identification of kynurenine and quinolinic acid as promising serum biomarkers for drug-induced interstitial lung diseases.

Yuchen Sun, Kosuke Saito, Atsuhito Ushiki, Mitsuhiro Abe, Yoshinobu Saito, Takeru Kashiwada, Yasushi Horimasu, Akihiko Gemma, Koichiro Tatsumi, Noboru Hattori …

Respiratory research 25(1) 31-31 2024年1月14日
Correlation between Membrane Permeability and the Intracellular Degradation Activity of Proteolysis-Targeting Chimeras.

Hidetomo Yokoo, Hinata Osawa, Kosuke Saito, Yosuke Demizu

Chemical & pharmaceutical bulletin 72(11) 961-965 2024年
Impact of microsampling on toxicological evaluation in rodent safety studies.

Kazuaki Takahashi, Norimichi Hattori, Hideaki Yokoyama, Fumihiro Jinno, Hirohiko Ohtsuka, Keiko Nakai, Asuka Takumi, Yusuke Shibui, Koki Yamaguchi, Taishi Shimazaki …

Journal of applied toxicology : JAT 2023年8月7日
Identification of the Stapled α-Helical Peptide ATSP-7041 as a Substrate and Strong Inhibitor of OATP1B1 In Vitro.

Rika Ishikawa, Kosuke Saito, Takashi Misawa, Yosuke Demizu, Yoshiro Saito

Biomolecules 13(6) 2023年6月16日
Multi-laboratory evaluation of immunoaffinity LC-MS-based glucagon-like peptide-1 assay.

Rika Ishikawa, Kosuke Saito, Hidehisa Tachiki, Ryoya Goda, Koji Arai, Hisao Shimizu, Tomohiro Andou, Kentaro Takahara, Hitoshi Uchiyama, Shin-Ichiro Nitta …

Bioanalysis 15(4) 207-218 2023年2月
Effect of microsampling (50 μL) on toxicological evaluation of methapyrilene, a hepatotoxic substance, in a collaborative 28-day study in female rats.

Norimichi Hattori, Hideaki Yokoyama, Asuka Takumi, Sayaka Kawaguchi, Koki Yamaguchi, Taishi Shimazaki, Yusuke Shibui, Kosuke Saito, Yoshiro Saito

The Journal of toxicological sciences 48(1) 1-14 2023年
Identification and characterization of lysophosphatidylcholine 14:0 as a biomarker for drug-induced lung disease.

Kosuke Saito, Akihiko Gemma, Koichiro Tatsumi, Noboru Hattori, Atsuhito Ushiki, Kenji Tsushima, Yoshinobu Saito, Mitsuhiro Abe, Yasushi Horimasu, Takeru Kashiwada …

Scientific reports 12(1) 19819-19819 2022年11月17日
Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage.

Noriaki Arakawa, Atsuhito Ushiki, Mitsuhiro Abe, Shinichiro Matsuyama, Yoshinobu Saito, Takeru Kashiwada, Yasushi Horimasu, Akihiko Gemma, Koichiro Tatsumi, Noboru Hattori …

Nature communications 13(1) 5854-5854 2022年10月4日
Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis.

Kosuke Saito, Rika Ishikawa, Isao Kitamura, Kumiko Ogawa, Noriaki Arakawa, Yuchen Sun, Kazuo Imai, Takuya Maeda, Yoshiro Saito, Chihiro Hasegawa

Journal of pharmacological sciences 150(2) 49-55 2022年10月
Development and multicenter validation of an LC-MS-based bioanalytical method for antisense therapeutics.

Yuchen Sun, Shin-Ichiro Nitta, Kosuke Saito, Ryuta Hosogai, Keiko Nakai, Ryoya Goda, Hisao Shimizu, Hisashi Fujita, Masaaki Kakehi, Kazuyuki Murata …

Bioanalysis 14(18) 1213-1227 2022年9月
Phosphatidylcholine (18:0/20:4), a potential biomarker to predict ethionamide-induced hepatic steatosis in rats.

Kyotaka Muta, Kosuke Saito, Yusuke Kemmochi, Taku Masuyama, Akio Kobayashi, Yoshiro Saito, Shoichiro Sugai

Journal of applied toxicology : JAT 42(9) 1533-1547 2022年3月22日
Comparative Evaluation of Plasma Metabolomic Data from Multiple Laboratories.

Shin Nishiumi, Yoshihiro Izumi, Akiyoshi Hirayama, Masatomo Takahashi, Motonao Nakao, Kosuke Hata, Daisuke Saigusa, Eiji Hishinuma, Naomi Matsukawa, Suzumi M Tokuoka …

Metabolites 12(2) 2022年2月1日
Lipidomic Analysis of Extracellular Vesicles Isolated from Human Plasma and Serum.

Yuchen Sun, Kosuke Saito, Yoshiro Saito

Methods in molecular biology (Clifton, N.J.) 2504 157-173 2022年
No obvious toxicological influences of 50 μL microsampling from rats administered phenacetin as a drug with hematological toxicity.

Hirohiko Ohtsuka, Kazuaki Takahashi, Harumi Kitaura, Hitoshi Kandori, Kenta Danbayashi, Tomoaki Higuchi, Fumihiro Jinno, Shin-Ichiro Nitta, Kanae Mori, Atsushi Iwai …

The Journal of toxicological sciences 47(5) 193-199 2022年

もっとみる

MISC

非天然型構造を有する化学合成ペプチド医薬品の非臨床安全性評価に関するガイドライン案

斎藤嘉朗, 杉山圭一, 三島雅之, 齊藤公亮, 石井明子, 出水庸介, 直田みさき, 真木一茂

The Journal of Toxicological Sciences 49(Suppl.) S219-S219 2024年7月
血漿中のPeptide-drug conjugate BT1718のLC-MS/MSによる定量分析法の構築とバリデーション

石川リカ, 齊藤公亮, 三澤隆史, 出水庸介, 斎藤嘉朗, 花尻(木倉)瑠理

バイオメディカル分析科学シンポジウム講演要旨集 36th (CD-ROM) 2024年
PLASMA LIPID PROFILING OF CHEMICAL-INDUCED LIVER INJURIES

Kosuke Saito, Masaki Ishikawa, Hiroshi Yamada, Noriyuki Nakatsu, Keiko Maekawa, Yoshiro Saito

DRUG METABOLISM AND PHARMACOKINETICS 32(1) S33-S33 2017年1月
臓器特異的なミトコンドリア毒性とリン脂質解析

瀬川雅博, 齊藤公亮, 関根秀一, 斎藤嘉朗, 伊藤晃成

The Journal of Toxicological Sciences 41(Suppl.) S345-S345 2016年6月
Liver lipid profiling of chemical-induced phospholipidosis

Kosuke Saito, Masaki Ishikawa, Hiroshi Yamada, Noriyuki Nakatsu, Keiko Maekawa, Yoshiro Saito

FASEB JOURNAL 30 2016年4月
健常日本人,白人及び黒人における血漿中の脂質代謝物レベルの相違

前川京子, 桶本和男, 桶本和男, 嶽本和久, 豊島克子, 石川将己, 齊藤公亮, 田中理英子, 熊谷雄治, 斎藤嘉朗

日本薬学会年会要旨集(CD-ROM) 136th 2016年
IMPACT OF GENDER, AGE AND FED/FASTED STATE OF RATS ON THEIR SERUM HYDROPHILIC METABOLITES

Keiko Maekawa, Kosuke Saito, Kirk Pappan, Masaki Ishikawa, Masayo Urata, Yoko Tajima, Mayumi Murayama, Yuji Kumagai, Yoshiro Saito

DRUG METABOLISM REVIEWS 47 183-183 2015年11月
COMPARISON OF PLASMA LIPIDOMIC PROFILE OF HUMANS WITH PRECLINICAL ANIMALS

Kosuke Saito, Masayo Urata, Katsuko Toyoshima, Masaki Ishikawa, Mayumi Murayama, Yoko Tajima, Yuya Senoo, Kazuhisa Takemoto, Yuji Kumagai, Keiko Maekawa …

DRUG METABOLISM REVIEWS 47 146-147 2015年11月
METABOLOMICS-BASED ANALYSES ON DILATED CARDIOMYOPATHY AND ALZHEIMER'S DISEASE

Yoshiro Saito, Keiko Maekawa, Kosuke Saito, Masaki Ishikawa, Akiyoshi Hirayama, Tomoyoshi Soga

DRUG METABOLISM REVIEWS 47 17-17 2015年11月
CHARACTERIZATION OF HEPATIC LIPID PROFILES OF NONALCOHOLIC STEATOHEPATITIS (NASH) AND FOLLOWING FIBROSIS USING A MOUSE MODEL

Masaki Ishikawa, Kosuke Saito, Takashi Uebansou, Keiko Maekawa, Yuya Senoo, Mayumi Murayama, Yoko Tajima, Tomoko Nishimaki-Mogami, Hiroki Nakanishi, Kazutaka Ikeda …

DRUG METABOLISM REVIEWS 47 186-186 2015年11月
ラット血清中の内因性代謝物レベルの雄雌差に関する網羅的検討

石川将己, 前川京子, 齊藤公亮, 浦田政世, 田島陽子, 村山真由子, 妹尾勇弥, 熊谷雄治, 斎藤嘉朗

日本薬学会年会要旨集(CD-ROM) 134th 2014年
LIPIDOMIC PROFILES IN BLOOD FROM FASTED HEALTHY ADULTS VARY BETWEEN PLASMA AND SERUM AND BY SUBJECT'S GENDERS AND AGES

Masaki Ishikawa, Keiko Maekawa, Yuya Senoo, Yoko Tajima, Kosuke Saito, Masayo Urata, Mayumi Murayama, Yuji Kumagai, Yoshiro Saito

DRUG METABOLISM REVIEWS 45 52-52 2014年1月
THE DIFFERENCE IN THE METABOLITE PROFILES BETWEEN PLASMA AND SERUM, AGES OR SEXES, AND THEIR INTER-INDIVIDUAL VARIATIONS IN HUMAN SUBJECTS

Kosuke Saito, Keiko Maekawa, Kirk Pappan, Masayo Urata, Masaki Ishikawa, Yuji Kumagai, Yoshiro Saito

DRUG METABOLISM REVIEWS 45 47-47 2014年1月
メタボロミクスを用いた肝臓性リン脂質症の血中バイオマーカー探索

齊藤公亮, 前川京子, 浦田政代, 村山真由子, 妹尾勇弥, 石川将己, 田島陽子, 中津則之, 山田弘, 斎藤嘉朗

臨床薬理 44(Supplement) 2013年
p38 MAPK signaling determines CAR-mediated activation of the CYP2B genes by xenobiotics

Kosuke Saito, Rick Moore, Masahiko Negishi

FASEB JOURNAL 26 2012年4月
Functional characterization and differentiation potential of conditionally immortalized human brain microvascular endothelial cells

Atsuko Kamiichi, Tomomi Furihata, Satoshi Kishida, Yuki Ohta, Kosuke Saito, Kan Chiba

DRUG METABOLISM REVIEWS 43 36-37 2011年5月
The K+ Channel KCNK1: CAR-mediated Gene Regulation of Male-specific Induction by PB and Hepatic Hypertrophy

Kosuke Saito, Rick Moore, Hiroki Kamino, Masahiko Negishi

FASEB JOURNAL 25 2011年4月
hiBMEC/kyas, A NEWLY IMMORTALIZED HUMAN BRAIN MICROVASCULAR ENDOTHELIAL CELL LINE, IS A PROMISING TOOL FOR AN IN VITRO BLOOD-BRAIN BARRIER MODEL

Satoshi Kishida, Tomomi Furihata, Atsuko Kamiichi, Yuki Ohta, Kosuke Saito, Kan Chiba

DRUG METABOLISM REVIEWS 42 313-313 2010年8月
INVOLVEMENT OF HNF4A AND ITS MODULATORS IN THE HIGH EXPRESSION OF CAR IN THE HUMAN LIVER

Kosuke Saito, Kaoru Kobayashi, Shoko Shimizu, Norihiko Iwazaki, Kan Chiba

DRUG METABOLISM REVIEWS 39 382-382 2007年
HMG-CoA reductase inhibitors activate human and rat pregnane X receptor as ligands

Kosuke Saito, Kaoru Kobayashi, Kan Chiba

DRUG METABOLISM REVIEWS 38 117-117 2006年

共同研究・競争的資金等の研究課題

メタボロミクス解析を用いた薬剤性間質性肺炎の発症メカニズムの解明

日本学術振興会科学研究費助成事業若手研究(B) 2015年4月 - 2018年3月

齊藤公亮

齊藤公亮

基本情報

研究分野

論文

MISC

共同研究・競争的資金等の研究課題

メニュー

共著者の一覧