Kosuke Saito

Profile Information

Affiliation: National Institute of Health Sciences

J-GLOBAL ID: 201801015181592430
researchmap Member ID: B000309549

Research Areas

Life sciences / Pharmaceuticals - analytical and physicochemistry /

Papers

Identification of kynurenine and quinolinic acid as promising serum biomarkers for drug-induced interstitial lung diseases.

Yuchen Sun, Kosuke Saito, Atsuhito Ushiki, Mitsuhiro Abe, Yoshinobu Saito, Takeru Kashiwada, Yasushi Horimasu, Akihiko Gemma, Koichiro Tatsumi, Noboru Hattori …

Respiratory research, 25(1) 31-31, Jan 14, 2024
Impact of microsampling on toxicological evaluation in rodent safety studies.

Kazuaki Takahashi, Norimichi Hattori, Hideaki Yokoyama, Fumihiro Jinno, Hirohiko Ohtsuka, Keiko Nakai, Asuka Takumi, Yusuke Shibui, Koki Yamaguchi, Taishi Shimazaki …

Journal of applied toxicology : JAT, Aug 7, 2023
Identification of the Stapled α-Helical Peptide ATSP-7041 as a Substrate and Strong Inhibitor of OATP1B1 In Vitro.

Rika Ishikawa, Kosuke Saito, Takashi Misawa, Yosuke Demizu, Yoshiro Saito

Biomolecules, 13(6), Jun 16, 2023
Multi-laboratory evaluation of immunoaffinity LC-MS-based glucagon-like peptide-1 assay.

Rika Ishikawa, Kosuke Saito, Hidehisa Tachiki, Ryoya Goda, Koji Arai, Hisao Shimizu, Tomohiro Andou, Kentaro Takahara, Hitoshi Uchiyama, Shin-Ichiro Nitta …

Bioanalysis, 15(4) 207-218, Feb, 2023
Effect of microsampling (50 μL) on toxicological evaluation of methapyrilene, a hepatotoxic substance, in a collaborative 28-day study in female rats.

Norimichi Hattori, Hideaki Yokoyama, Asuka Takumi, Sayaka Kawaguchi, Koki Yamaguchi, Taishi Shimazaki, Yusuke Shibui, Kosuke Saito, Yoshiro Saito

The Journal of toxicological sciences, 48(1) 1-14, 2023
Identification and characterization of lysophosphatidylcholine 14:0 as a biomarker for drug-induced lung disease.

Kosuke Saito, Akihiko Gemma, Koichiro Tatsumi, Noboru Hattori, Atsuhito Ushiki, Kenji Tsushima, Yoshinobu Saito, Mitsuhiro Abe, Yasushi Horimasu, Takeru Kashiwada …

Scientific reports, 12(1) 19819-19819, Nov 17, 2022
Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage.

Noriaki Arakawa, Atsuhito Ushiki, Mitsuhiro Abe, Shinichiro Matsuyama, Yoshinobu Saito, Takeru Kashiwada, Yasushi Horimasu, Akihiko Gemma, Koichiro Tatsumi, Noboru Hattori …

Nature communications, 13(1) 5854-5854, Oct 4, 2022
Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis.

Kosuke Saito, Rika Ishikawa, Isao Kitamura, Kumiko Ogawa, Noriaki Arakawa, Yuchen Sun, Kazuo Imai, Takuya Maeda, Yoshiro Saito, Chihiro Hasegawa

Journal of pharmacological sciences, 150(2) 49-55, Oct, 2022
Development and multicenter validation of an LC-MS-based bioanalytical method for antisense therapeutics.

Yuchen Sun, Shin-Ichiro Nitta, Kosuke Saito, Ryuta Hosogai, Keiko Nakai, Ryoya Goda, Hisao Shimizu, Hisashi Fujita, Masaaki Kakehi, Kazuyuki Murata …

Bioanalysis, 14(18) 1213-1227, Sep, 2022
Phosphatidylcholine (18:0/20:4), a potential biomarker to predict ethionamide-induced hepatic steatosis in rats.

Kyotaka Muta, Kosuke Saito, Yusuke Kemmochi, Taku Masuyama, Akio Kobayashi, Yoshiro Saito, Shoichiro Sugai

Journal of applied toxicology : JAT, 42(9) 1533-1547, Mar 22, 2022
Comparative Evaluation of Plasma Metabolomic Data from Multiple Laboratories.

Shin Nishiumi, Yoshihiro Izumi, Akiyoshi Hirayama, Masatomo Takahashi, Motonao Nakao, Kosuke Hata, Daisuke Saigusa, Eiji Hishinuma, Naomi Matsukawa, Suzumi M Tokuoka …

Metabolites, 12(2), Feb 1, 2022
Lipidomic Analysis of Extracellular Vesicles Isolated from Human Plasma and Serum.

Yuchen Sun, Kosuke Saito, Yoshiro Saito

Methods in molecular biology (Clifton, N.J.), 2504 157-173, 2022
No obvious toxicological influences of 50 μL microsampling from rats administered phenacetin as a drug with hematological toxicity.

Hirohiko Ohtsuka, Kazuaki Takahashi, Harumi Kitaura, Hitoshi Kandori, Kenta Danbayashi, Tomoaki Higuchi, Fumihiro Jinno, Shin-Ichiro Nitta, Kanae Mori, Atsushi Iwai …

The Journal of toxicological sciences, 47(5) 193-199, 2022
A multilaboratory validation study of LC/MS biomarker assays for three lysophosphatidylcholines.

Rika Ishikawa, Kosuke Saito, Tsuyoshi Matsumura, Koji Arai, Saki Yamauchi, Ryoya Goda, Hidehisa Tachiki, Mitsuhiko Kawabata, Shin-Ichiro Nitta, Akemi Nagao …

Bioanalysis, 13(20) 1533-1546, Oct, 2021
Analytical method validation for biomarkers as a drug development tool: points to consider.

Yoshiaki Ohtsu, Seiji Tanaka, Harue Igarashi, Masaaki Kakehi, Tamiki Mori, Takahiro Nakamura, Rui Ohashi, Hiroyuki Shimizu, Yutaka Yasuda, Takashige Okayama …

Bioanalysis, 13(18) 1379-1389, Sep, 2021
Omics analyses and their application for the discovery of biomarkers reflecting drug efficacy and adverse reaction.

Seigo Sanoh, Kosuke Saito

Drug metabolism and pharmacokinetics, 39 100405-100405, Aug, 2021
Profiling of Cerebrospinal Fluid Lipids and Their Relationship with Plasma Lipids in Healthy Humans.

Kosuke Saito, Kotaro Hattori, Shinsuke Hidese, Daimei Sasayama, Tomoko Miyakawa, Ryo Matsumura, Megumi Tatsumi, Yuuki Yokota, Miho Ota, Hiroaki Hori …

Metabolites, 11(5), Apr 24, 2021
Application of comprehensive lipidomics to biomarker research on adverse drug reactions.

Kosuke Saito

Drug metabolism and pharmacokinetics, 37 100377-100377, Apr, 2021
Development of a bioanalytical method for an antisense therapeutic using high-resolution mass spectrometry

Yuchen Sun, Shin-ichiro Nitta, Kosuke Saito, Ryuta Hosogai, Keiko Nakai, Ryoya Goda, Masaaki Kakehi, Kazuyuki Murata, Takeru Yamaguchi, Takeshi Okuzono …

Bioanalysis, 12(24) 1739-1756, Dec, 2020
Plasma Lipid Profiling of Three Types of Drug-Induced Liver Injury in Japanese Patients: A Preliminary Study

Kosuke Saito, Tatehiro Kagawa, Keiji Tsuji, Yuji Kumagai, Ken Sato, Shotaro Sakisaka, Naoya Sakamoto, Mitsuhiko Aiso, Shunji Hirose, Nami Mori …

Metabolites, 10(9) 355-355, Aug 31, 2020

Misc.

PLASMA LIPID PROFILING OF CHEMICAL-INDUCED LIVER INJURIES

Kosuke Saito, Masaki Ishikawa, Hiroshi Yamada, Noriyuki Nakatsu, Keiko Maekawa, Yoshiro Saito

DRUG METABOLISM AND PHARMACOKINETICS, 32(1) S33-S33, Jan, 2017
臓器特異的なミトコンドリア毒性とリン脂質解析

瀬川雅博, 齊藤公亮, 関根秀一, 斎藤嘉朗, 伊藤晃成

The Journal of Toxicological Sciences, 41(Suppl.) S345-S345, Jun, 2016
Liver lipid profiling of chemical-induced phospholipidosis

Kosuke Saito, Masaki Ishikawa, Hiroshi Yamada, Noriyuki Nakatsu, Keiko Maekawa, Yoshiro Saito

FASEB JOURNAL, 30, Apr, 2016
健常日本人,白人及び黒人における血漿中の脂質代謝物レベルの相違

前川京子, 桶本和男, 桶本和男, 嶽本和久, 豊島克子, 石川将己, 齊藤公亮, 田中理英子, 熊谷雄治, 斎藤嘉朗

日本薬学会年会要旨集(CD-ROM), 136th, 2016
IMPACT OF GENDER, AGE AND FED/FASTED STATE OF RATS ON THEIR SERUM HYDROPHILIC METABOLITES

Keiko Maekawa, Kosuke Saito, Kirk Pappan, Masaki Ishikawa, Masayo Urata, Yoko Tajima, Mayumi Murayama, Yuji Kumagai, Yoshiro Saito

DRUG METABOLISM REVIEWS, 47 183-183, Nov, 2015
COMPARISON OF PLASMA LIPIDOMIC PROFILE OF HUMANS WITH PRECLINICAL ANIMALS

Kosuke Saito, Masayo Urata, Katsuko Toyoshima, Masaki Ishikawa, Mayumi Murayama, Yoko Tajima, Yuya Senoo, Kazuhisa Takemoto, Yuji Kumagai, Keiko Maekawa …

DRUG METABOLISM REVIEWS, 47 146-147, Nov, 2015
METABOLOMICS-BASED ANALYSES ON DILATED CARDIOMYOPATHY AND ALZHEIMER'S DISEASE

Yoshiro Saito, Keiko Maekawa, Kosuke Saito, Masaki Ishikawa, Akiyoshi Hirayama, Tomoyoshi Soga

DRUG METABOLISM REVIEWS, 47 17-17, Nov, 2015
CHARACTERIZATION OF HEPATIC LIPID PROFILES OF NONALCOHOLIC STEATOHEPATITIS (NASH) AND FOLLOWING FIBROSIS USING A MOUSE MODEL

Masaki Ishikawa, Kosuke Saito, Takashi Uebansou, Keiko Maekawa, Yuya Senoo, Mayumi Murayama, Yoko Tajima, Tomoko Nishimaki-Mogami, Hiroki Nakanishi, Kazutaka Ikeda …

DRUG METABOLISM REVIEWS, 47 186-186, Nov, 2015
ラット血清中の内因性代謝物レベルの雄雌差に関する網羅的検討

石川将己, 前川京子, 齊藤公亮, 浦田政世, 田島陽子, 村山真由子, 妹尾勇弥, 熊谷雄治, 斎藤嘉朗

日本薬学会年会要旨集(CD-ROM), 134th, 2014
LIPIDOMIC PROFILES IN BLOOD FROM FASTED HEALTHY ADULTS VARY BETWEEN PLASMA AND SERUM AND BY SUBJECT'S GENDERS AND AGES

Masaki Ishikawa, Keiko Maekawa, Yuya Senoo, Yoko Tajima, Kosuke Saito, Masayo Urata, Mayumi Murayama, Yuji Kumagai, Yoshiro Saito

DRUG METABOLISM REVIEWS, 45 52-52, Jan, 2014
THE DIFFERENCE IN THE METABOLITE PROFILES BETWEEN PLASMA AND SERUM, AGES OR SEXES, AND THEIR INTER-INDIVIDUAL VARIATIONS IN HUMAN SUBJECTS

Kosuke Saito, Keiko Maekawa, Kirk Pappan, Masayo Urata, Masaki Ishikawa, Yuji Kumagai, Yoshiro Saito

DRUG METABOLISM REVIEWS, 45 47-47, Jan, 2014
メタボロミクスを用いた肝臓性リン脂質症の血中バイオマーカー探索

齊藤公亮, 前川京子, 浦田政代, 村山真由子, 妹尾勇弥, 石川将己, 田島陽子, 中津則之, 山田弘, 斎藤嘉朗

臨床薬理, 44(Supplement), 2013
p38 MAPK signaling determines CAR-mediated activation of the CYP2B genes by xenobiotics

Kosuke Saito, Rick Moore, Masahiko Negishi

FASEB JOURNAL, 26, Apr, 2012
Functional characterization and differentiation potential of conditionally immortalized human brain microvascular endothelial cells

Atsuko Kamiichi, Tomomi Furihata, Satoshi Kishida, Yuki Ohta, Kosuke Saito, Kan Chiba

DRUG METABOLISM REVIEWS, 43 36-37, May, 2011
The K+ Channel KCNK1: CAR-mediated Gene Regulation of Male-specific Induction by PB and Hepatic Hypertrophy

Kosuke Saito, Rick Moore, Hiroki Kamino, Masahiko Negishi

FASEB JOURNAL, 25, Apr, 2011
hiBMEC/kyas, A NEWLY IMMORTALIZED HUMAN BRAIN MICROVASCULAR ENDOTHELIAL CELL LINE, IS A PROMISING TOOL FOR AN IN VITRO BLOOD-BRAIN BARRIER MODEL

Satoshi Kishida, Tomomi Furihata, Atsuko Kamiichi, Yuki Ohta, Kosuke Saito, Kan Chiba

DRUG METABOLISM REVIEWS, 42 313-313, Aug, 2010
INVOLVEMENT OF HNF4A AND ITS MODULATORS IN THE HIGH EXPRESSION OF CAR IN THE HUMAN LIVER

Kosuke Saito, Kaoru Kobayashi, Shoko Shimizu, Norihiko Iwazaki, Kan Chiba

DRUG METABOLISM REVIEWS, 39 382-382, 2007
HMG-CoA reductase inhibitors activate human and rat pregnane X receptor as ligands

Kosuke Saito, Kaoru Kobayashi, Kan Chiba

DRUG METABOLISM REVIEWS, 38 117-117, 2006

Research Projects

Metabolomics approach for understanding the underlying mechanism of durg induced lung injury

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Saito Kosuke

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