1970年1月
Volumetric-modulated arc therapy vs conventional fixed-field intensity-Modulated radiotherapy in a whole-ventricular irradiation: A planning comparison study
MEDICAL DOSIMETRY
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- 巻
- 38
- 号
- 2
- 開始ページ
- 204
- 終了ページ
- 208
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.meddos.2013.01.004
- 出版者・発行元
- ELSEVIER SCIENCE INC
This study evaluated the dosimetric difference between volumetric-modulated arc therapy (VMAT) and conventional fixed-field intensity-modulated radiotherapy (cIMRT) in whole-ventricular irradiation. Computed tomography simulation data for 13 patients were acquired to create plans for VMAT and cIMRT. In both plans, the same median dose (100% = 24 Gy) was prescribed to the planning target volume (PTV), which comprised a tumor bed and whole ventricles. During optimization, doses to the normal brain and body were reduced, provided that the dose constraints of the target coverage were satisfied. The dose-volume indices of the PTV, normal brain, and body as well as monitor units were compared between the 2 techniques by using paired t-tests. The results showed no significant difference in the homogeneity index (0.064 vs 0.065; p = 0.824) of the PTV and conformation number (0.78 vs 0.77; p = 0.065) between the 2 techniques. In the normal brain and body, the dose-volume indices showed no significant difference between the 2 techniques, except for an increase in the volume receiving a low dose in VMAT; the absolute volume of the normal brain and body receiving 1 Gy of radiation significantly increased in VMAT by 1.6% and 8.3%, respectively, compared with that in cIMRT " (1044 vs 1028 mL for the normal brain and 3079.2 vs 2823.3 mL for the body; p <0.001). The number of monitor units to deliver a 2.0-Gy fraction was significantly reduced in VMAT compared with that in cIMRT (354 vs 873, respectively: p < 0.001). In conclusion, VMAT delivers IMRT to complex target volumes such as whole ventricles with fewer monitor units, while maintaining target coverage and conformal isodose distribution comparable to cIMRT; however, in addition to those characteristics, the fact that the volume of the normal brain and body receiving a low dose would increase in VMAT should be considered. (C) 2013 American Association of Medical Dosimetrists.
- リンク情報
- ID情報
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- DOI : 10.1016/j.meddos.2013.01.004
- ISSN : 0958-3947
- Web of Science ID : WOS:000318828800020