2014年10月
Novel RNA recognition motif domain in the cytoplasmic polyadenylation element binding protein 3
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
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- 巻
- 82
- 号
- 10
- 開始ページ
- 2879
- 終了ページ
- 2886
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/prot.24651
- 出版者・発行元
- WILEY-BLACKWELL
The family of cytoplasmic polyadenylation element binding proteins CPEB1, CPEB2, CPEB3, and CPEB4 binds to the 3'-untranslated region (3'-UTR) of mRNA, and plays significant roles in mRNA metabolism and translation regulation. They have a common domain organization, involving two consecutive RNA recognition motif (RRM) domains followed by a zinc finger domain in the C-terminal region. We solved the solution structure of the first RRM domain (RRM1) of human CPEB3, which revealed that CPEB3 RRM1 exhibits structural features distinct from those of the canonical RRM domain. Our structural data provide important information about the RNA binding ability of CPEB3 RRM1. (C) 2014 Wiley Periodicals, Inc.
- リンク情報
- ID情報
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- DOI : 10.1002/prot.24651
- ISSN : 0887-3585
- eISSN : 1097-0134
- Web of Science ID : WOS:000342849400050