Sakumoto Ryosuke

Profile Information

Affiliation: Institute of Livestock and Grassland Science, NARO, Animal Breeding and Reproduction Research Division, National Agriculture and Food Research Organization
: University of Tsukuba

Degree: Ph.D(Okayama University)

J-GLOBAL ID: 201601018384530656
researchmap Member ID: B000259341

専門分野は「家畜の生殖生理学/内分泌学」で、妊娠が成立する際に母体（卵巣や子宮、血球）で生じる生理的変化の解析、ならびにストレスや免疫が妊娠におよぼす影響などについて研究しています。これらの基盤的な研究成果をベースにして、家畜の「不妊症の改善」や「低コストで効率的な繁殖制御技術の開発」に貢献したいと考えています。

Research Interests

Research Areas

Life sciences / Animal production science /

Research History

Apr, 2021 - Present

グループ長, 高度飼養技術研究領域繁殖システムグループ, 農研機構畜産研究部門
Mar, 2021 - Present

教授, 生命環境系生物圏資源科学専攻動物生産機能学分野, 筑波大学
Oct, 2020 - Mar, 2021

ユニット長, 農研機構畜産研究部門家畜育種繁殖研究領域繁殖性向上ユニット
Nov, 2018 - Sep, 2020

上級研究員, 農研機構企画戦略本部スマート農業実証事業推進室
Apr, 2016 - Oct, 2018

National Agriculture and Food Research Organization
Apr, 2012 - Mar, 2016

主任研究員, 動物生産生理機能研究ユニット, 農業生物資源研究所
Apr, 2010 - Mar, 2012

Ministry of Agriculture, Forestry and Fisheries
Apr, 2005 - Mar, 2010

主任研究員, 生殖機構研究ユニット, 農業生物資源研究所
Jul, 2006 - Jul, 2008

フンボルト財団奨学研究員, 獣医学部, ミュンヘン大学
Apr, 2001 - Mar, 2005

研究員, 生体機能研究グループ, 農業生物資源研究所
Apr, 2000 - Mar, 2001

Ministry of Agriculture, Forestry and Fisheries

Papers

Possible roles of bone morphogenetic protein 4 in regulating endometrial function in cows

Yuki Koizumi, Ken‐Go Hayashi, Ryosuke Sakumoto

Animal Science Journal, Aug, 2023
Differential expression of pro- and anti-angiogenic factors in the endometrium between repeat breeder and normally fertile cows.

Ken-Go Hayashi, Ryosuke Sakumoto

Animal reproduction science, 254 107265-107265, Jul, 2023
Direct effects of linoleic and linolenic acids on bovine uterine function using in vivo and in vitro studies.

Ryosuke Sakumoto, Ken-Go Hayashi, Kosuke Iga

The Journal of reproduction and development, 68(1) 62-67, Nov 20, 2021
Heat stress influences the attenuation of prostaglandin synthesis by interferon tau in bovine endometrial cells.

Shunsuke Sakai, Mami Yagi, Nao Fujime, Mariko Kuse, Ryosuke Sakumoto, Yuki Yamamoto, Kiyoshi Okuda, Koji Kimura

Theriogenology, 165 52-58, Apr 15, 2021
Pregnancy-associated changes of peroxisome proliferator-activated receptor delta (PPARD) and cytochrome P450 family 21 subfamily A member 2 (CYP21A2) expression in the bovine corpus luteum.

Ryosuke Sakumoto, Ken-Go Hayashi, Misa Hosoe, Kosuke Iga, Keiichiro Kizaki

The Journal of reproduction and development, 66(3) 205-213, Jun 12, 2020 Peer-reviewed
The chemokines CCL2 and CXCL10 produced by bovine endometrial epithelial cells induce migration of bovine B lymphocytes, contributing to transuterine transmission of BLV infection.

Kiyohiko Andoh, Asami Nishimori, Ryosuke Sakumoto, Ken-Go Hayashi, Shinichi Hatama

Veterinary microbiology, 242 108598-108598, Mar, 2020 Peer-reviewed
Expression of C-C motif chemokines and their receptors in bovine placentomes at spontaneous and induced parturition.

Hiroki Hirayama, Ryosuke Sakumoto, Keisuke Koyama, Taichi Yasuhara, Taito Hasegawa, Ryo Inaba, Takashi Fujii, Akira Naito, Satoru Moriyasu, Soichi Kageyama

The Journal of reproduction and development, 66(1) 49-55, Feb 14, 2020 Peer-reviewed
Enhanced glucocorticoid exposure facilitates the expression of genes involved in prostaglandin and estrogen syntheses in bovine placentomes at induced parturition.

Taichi Yasuhara, Keisuke Koyama, Ryosuke Sakumoto, Takashi Fujii, Akira Naito, Satoru Moriyasu, Soichi Kageyama, Hiroki Hirayama

Theriogenology, 139 1-7, Nov, 2019 Peer-reviewed
Temporal expression and localization of vascular endothelial growth factor family members in the bovine uterus during peri-implantation period.

Ken-Go Hayashi, Misa Hosoe, Shiori Fujii, Hiroko Kanahara, Ryosuke Sakumoto

Theriogenology, 133 56-64, Jul 15, 2019 Peer-reviewed
Characterisation of bovine embryos following prolonged culture in embryonic stem cell medium containing leukaemia inhibitory factor.

Misa Hosoe, Tadashi Furusawa, Ken-Go Hayashi, Toru Takahashi, Yutaka Hashiyada, Keiichiro Kizaki, Kazuyoshi Hashizume, Tomoyuki Tokunaga, Shuichi Matsuyama, Ryosuke Sakumoto

Reproduction, fertility, and development, 31(6) 1157-1165, May, 2019 Peer-reviewed
Involvement of interferon-tau in the induction of apoptotic, pyroptotic, and autophagic cell death-related signaling pathways in the bovine uterine endometrium during early pregnancy.

Toshiyuki Suzuki, Ryosuke Sakumoto, Ken-Go Hayashi, Takatoshi Ogiso, Hiroki Kunii, Takahiro Shirozu, Sung-Woo Kim, Hanako Bai, Manabu Kawahara, Koji Kimura …

The Journal of reproduction and development, 64(6) 495-502, Dec 14, 2018 Peer-reviewed
Gene expression of CCL8 and CXCL10 in peripheral blood leukocytes during early pregnancy in cows.

Ryosuke Sakumoto, Kosuke Iga, Ken-Go Hayashi, Shiori Fujii, Hiroko Kanahara, Misa Hosoe, Tadashi Furusawa

Journal of animal science and biotechnology, 9(1) 46-46, 2018 Peer-reviewed
Generation of recombinant bovine interferon tau in the human embryonic kidney cell line and its biological activity.

Toru Takahashi, Ryosuke Sakumoto, Ken-Go Hayashi, Misa Hosoe, Junsuke Shirai, Kazuyoshi Hashizume

Animal science journal = Nihon chikusan Gakkaiho, 88(10) 1498-1505, Oct, 2017 Peer-reviewed
Possible Roles of CC- and CXC-Chemokines in Regulating Bovine Endometrial Function during Early Pregnancy.

Ryosuke Sakumoto, Ken-Go Hayashi, Shiori Fujii, Hiroko Kanahara, Misa Hosoe, Tadashi Furusawa, Keiichiro Kizaki

International journal of molecular sciences, 18(4), Mar 31, 2017 Peer-reviewed
Differential gene expression profiling of endometrium during the mid-luteal phase of the estrous cycle between a repeat breeder (RB) and non-RB cows.

Ken-Go Hayashi, Misa Hosoe, Keiichiro Kizaki, Shiori Fujii, Hiroko Kanahara, Toru Takahashi, Ryosuke Sakumoto

Reproductive biology and endocrinology : RB&E, 15(1) 20-20, Mar 23, 2017 Peer-reviewed
Pregnancy-associated changes in uterine-luteal relationships in cows: A mini-review.

Ryosuke Sakumoto

Reproductive biology, 16(2) 182-8, Jun, 2016 Peer-reviewed
Genomic and non-genomic effects of progesterone on prostaglandin (PG) F2? and PGE2 production in the bovine endometrium.

Mariko Kuse, Ryosuke Sakumoto, Kiyoshi Okuda

Reproduction, fertility, and development, 28(10) 1588-1597, Apr 21, 2015 Peer-reviewed
Gene expression profiles in the bovine corpus luteum (CL) during the estrous cycle and pregnancy: possible roles of chemokines in regulating CL function during pregnancy.

Ryosuke Sakumoto, Ken-Go Hayashi, Misa Hosoe, Kosuke Iga, Keiichiro Kizaki, Kiyoshi Okuda

The Journal of reproduction and development, 61(1) 42-8, 2015 Peer-reviewed
Expression of matrix metalloproteinases in bovine luteal cells induced by prostaglandin F2α, interferon γ and tumor necrosis factor α.

Hironori Abe, Ryosuke Sakumoto, Kiyoshi Okuda

The Journal of reproduction and development, 61(4) 277-86, 2015 Peer-reviewed
Comparison of the global gene expression profiles in the bovine endometrium between summer and autumn.

Ryosuke Sakumoto, Ken-Go Hayashi, Shiori Saito, Hiroko Kanahara, Keiichiro Kizaki, Kosuke Iga

The Journal of reproduction and development, 61(4) 297-303, 2015 Peer-reviewed

Misc.

111

牛子宮内膜細胞が分泌するケモカインにより,牛伝染性リンパ腫ウイルス感染B細胞が誘引される

安藤清彦, 西森朝美, 作本亮介, 林憲悟, 畠間真一

農研機構動物衛生研究部門成果情報(Web), 2020, 2020
アドレノメデュリンがウシ栄養膜細胞株の遊走能および浸潤能に及ぼす効果

林憲悟, 細江実佐, 作本亮介

The Journal of Reproduction and Development, 65(Suppl.) j136-j136, Sep, 2019
着床期のウシ子宮内膜における血管内皮細胞増殖因子Bの発現動態と血管数の変化

林憲悟, 細江実佐, 作本亮介

農研機構畜産研究部門成果情報(Web), 2019, 2019
胚性シグナルを介した新たな牛の妊娠認識機構

作本亮介, 林憲悟, 細江実佐, 伊賀浩輔, 古澤軌, 木崎景一郎

農研機構畜産研究部門成果情報(Web), 2019, 2019
ウシ脾臓細胞におけるインターフェロンτの免疫細胞分化誘導の可能性の検討

江口空, 鬼沢優里, 舟島なつみ, 宗像祥久, 作本亮介, 坂上信忠, 岩田尚孝, 桑山岳人, 白砂孔明

Journal of Reproduction and Development, 64(Suppl Japanese Issue) j112, Sep 5, 2018
リピートブリーダー牛の繁殖救済を目指した単為発生胚追い移植の効果の検証

舟島なつみ, 柳沼日佳里, 野口龍生, 谷川奈央, 鬼沢優里, 濱野晴三, 宮村元晴, 細江実佐, 作本亮介, 古澤軌 …

Journal of Reproduction and Development, 64(Suppl Japanese Issue) j79, Sep 5, 2018
ウシ分娩時胎盤節における主要組織適合遺伝子複合体クラス1(BoLA‐1)発現

泰原大治, 古山敬祐, 作本亮介, 小林祐子, 平山博樹

Journal of Reproduction and Development, 64(Suppl Japanese Issue) j114, Sep 5, 2018
ウシ末梢血多核球と単核球におけるIFNT応答性と作用の比較検討

鬼沢優里, 江口空, 舟島なつみ, 作本亮介, 坂上信忠, 岩田尚孝, 桑山岳人, 白砂孔明

Journal of Reproduction and Development, 64(Suppl Japanese Issue) j112, Sep 5, 2018
牛子宮内膜細胞への牛白血病ウイルス感染機構の解析

安藤清彦, 西森朝美, 木村久美子, 林憲悟, 作本亮介, 畠間真一

日本獣医学会学術集会講演要旨集, 161st 350-350, Aug 21, 2018
乳牛のグルココルチコイド投与による誘起分娩時胎盤節におけるプロスタグランジン合成酵素発現

泰原大治, 古山敬祐, 作本亮介, 平山博樹

日本畜産学会大会講演要旨, 124th 207, Mar 28, 2018
牛の血中遺伝子発現ならびに内分泌変化を指標とした早期妊娠診断の試み

作本亮介

畜産技術, (751) 2‐7, Dec 1, 2017
グルココルチコイドによる誘起分娩がウシ胎盤節におけるプロスタグランジン合成酵素発現に及ぼす影響

平山博樹, 泰原大治, 古山敬祐, 作本亮介, 藤井貴志, 森安悟

日本畜産学会大会講演要旨, 122nd 162, Mar 28, 2017
開発した受胎性評価および超早期妊娠診断技術の実用性

伊賀浩輔, 松田秀雄, 窪友瑛, 窪友瑛, 吉野仁美, 吉野仁美, 木崎景一郎, 平田統一, 橋谷田豊, 高橋透 …

東日本家畜受精卵移植技術研究会大会資料, 33rd 46, 2017
ウシ伸長胚の生育に関わる子宮内膜上皮細胞由来因子の探索

細江実佐, 古澤軌, 上西博英, 林憲悟, 作本亮介

The Journal of Reproduction and Development, 62(Suppl.) j129-j129, Sep, 2016
ウシ着床期の胚および子宮におけるアドレノメデュリンの発現と機能解析

林憲悟, 細江実佐, 金原浩子, 藤井史織, 作本亮介

The Journal of Reproduction and Development, 62(Suppl.) j133-j133, Sep, 2016
ウシの妊娠認識におけるCC-、CXC-ケモカインの生理的役割

作本亮介, 林憲悟, 藤井史織, 金原浩子, 細江実佐, 古澤軌

The Journal of Reproduction and Development, 62(Suppl.) j134-j134, Sep, 2016
気候変動に対応した循環型食料生産等の確立のためのプロジェクト第2編地球温暖化が農業分野に与える影響評価と適応技術の開発第4章畜産・飼料作物における影響評価と適応技術の開発 1 高温環境下での家畜の繁殖障害を予察するための診断技術の開発(1)子宮内膜機能関連遺伝子の網羅的解析に基づく受胎性診断技術の開発

作本亮介, 林憲悟, 高橋透

農林水産省農林水産技術会議事務局研究成果, (557) 256-259, Mar 31, 2016
ウシ伸長胚評価マーカーの探索

細江実佐, 古澤軌, 林憲悟, 梶谷健治, 前野純, 徳永智之, 作本亮介

東日本家畜受精卵移植技術研究会大会資料, 31st 72-73, 2016
ウシ体外培養胚における胚盤形成マーカーの探索

細江実佐, 林憲悟, 作本亮介, 古澤軌, 大越勝広, 池田光美, 徳永智之

J Reprod Dev, 61(Suppl Japanese Issue) J143-66-P-66, Sep 5, 2015
妊娠早期のウシ子宮における血管内皮細胞増殖因子ファミリーの遺伝子発現動態と血管数およびリンパ管数の変化

林憲悟, 細江実佐, 金原浩子, 藤井史織, 作本亮介

J Reprod Dev, 61(Suppl Japanese Issue) J141, Sep 5, 2015

Research Projects

Chemokine cross talk mechanism between endometrium and immune cells during the maternal recognition in cows

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

SAKUMOTO RYOSUKE
Regulatory mechanism of ovarian and endometrial functions controlling the reproductive cycle

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2016

OKUDA KIYOSHI, SAKUMOTO Ryosuke
Difference in global gene expression profiles in the bovine corpus luteum of the estrous cycle and pregnancy

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

SAKUMOTO RYOSUKE
Studies on pregnant-specific substances in the bovine corpus luteum

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2009 - 2010

SAKUMOTO Ryosuke
ストレスによる生殖機能低下メカニズムの解明とその対処法の開発

科学研究費助成事業若手研究(B), 若手研究(B), 日本学術振興会, 2005 - 2006

作本亮介
家畜のストレス発現を調節する脳内メカニズムの解明及びその人為的制御法の探索

科学研究費助成事業若手研究(B), 若手研究(B), 日本学術振興会, 2002 - 2004

作本亮介
ウシ黄体機能調節機構の解明

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 1998 - 1999

作本亮介

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