2017年7月
Desipramine increases cardiac parasympathetic activity via alpha(2)-adrenergic mechanism in rats
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
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- 巻
- 205
- 号
- 開始ページ
- 21
- 終了ページ
- 25
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.autneu.2017.02.005
- 出版者・発行元
- ELSEVIER
Desipramine (DMI) is a blocker of neuronal norepinephrine (NE) uptake transporter. Although intravenous DMI has been shown to cause centrally-mediated sympathoinhibition and peripheral NE accumulation, its parasym-pathetic effect remains to be elucidated. We hypothesized that intravenous DMI activates the cardiac vagal nerve via an alpha(2)-adrenergic mechanism. Using a cardiac microdialysis technique, changes in myocardial interstitial acetylcholine (ACh) levels in the left ventricular free wall in response to intravenous DMI (1 mg center dot kg(-1)) were examined in anesthetized rats. In rats with intact vagi (n = 7), intravenous DMI increased ACh from 1.67 +/- 0.43 to 2.48 +/- 0.66 nM (P < 0.01). In rats with vagotomy (n = 5), DMI did not significantly change ACh (from 0.92 +/- 0.16 to 0.85 +/- 0.23 nM). In rats with intact vagi pretreated with intravenous yohimbine (2 mg center dot kg(-1)), DMI did not significantly change ACh (from 1.25 +/- 0.23 to 1.13 +/- 0.15 nM). In conclusion, while DMI is generally considered to be an agent that predominantly affects sympathetic neurotransmission, it can activate the cardiac vagal nerve via alpha(2)-adrenergic stimulation in experimental settings in vivo. (C) 2017 Elsevier B.V. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.autneu.2017.02.005
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/28242182
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000405047600003&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85013627557&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85013627557&origin=inward
- ID情報
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- DOI : 10.1016/j.autneu.2017.02.005
- ISSN : 1566-0702
- eISSN : 1872-7484
- PubMed ID : 28242182
- SCOPUS ID : 85013627557
- Web of Science ID : WOS:000405047600003