Tsutomu Shimura

J-GLOBAL         Last updated: Nov 14, 2018 at 19:11
 
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Name
Tsutomu Shimura
Affiliation
National Institute of Public Health

Research Areas

 
 

Academic & Professional Experience

 
Apr 2012
 - 
Today
Chief Senior Researcher, Department of Environmental Health, National Institue of Public Health
 
Aug 2007
 - 
Mar 2012
Assistant Professor, Department of Pathology, IDAC
 
Jun 2003
 - 
Oct 2006
Visiting Fellow, Laboratory of Molecular Phamacology, National Institute of Health, National Cancer Institute
 

Awards & Honors

 
May 2015
ICRR2015 Excellent Poster Award, 15th ICRR
 

Published Papers

 
Shimura Tsutomu, Sasatani Megumi, Kawai Hidehiko, Kamiya Kenji, Kobayashi Junya, Komatsu Kenshi, Kunugita Naoki
MOLECULAR CANCER RESEARCH   16(11) 1676-1686   Nov 2018   [Refereed]
Sasatani M, Xi Y, Kajimura J, Kawamura T, Piao J, Masuda Y, Honda H, Kubo K, Mikamoto T, Watanabe H, Xu Y, Kawai H, Shimura T, Noda A, Hamasaki K, Kusunoki Y, Zaharieva EK, Kamiya K
Carcinogenesis   38(5) 570-578   May 2017   [Refereed]
Shimura T
International journal of radiation biology   93(4) 381-385   Apr 2017   [Refereed]
Shimura T, Sasatani M, Kawai H, Kamiya K, Kobayashi J, Komatsu K, Kunugita N
Cell cycle (Georgetown, Tex.)   16(6) 565-573   Mar 2017   [Refereed]
Shimura T, Sasatani M, Kawai H, Kamiya K, Kobayashi J, Komatsu K, Kunugita N
Cell cycle (Georgetown, Tex.)   16(24) 2345-2354   2017   [Refereed]
Shimura T, Kunugita N
Cell cycle (Georgetown, Tex.)   15(11) 1410-1414   Jun 2016   [Refereed]
Shimura T, Kobayashi J, Komatsu K, Kunugita N
Cell cycle (Georgetown, Tex.)      Mar 2016   [Refereed]
Shimura T, Yamaguchi I, Terada H, Okuda K, Svendsen ER, Kunugita N
Journal of radiation research   56(3) 413-421   May 2015   [Refereed]
Shimura T, Sasatani M, Kamiya K, Kawai H, Inaba Y, Kunugita N
Oncotarget   7(3) 3559-3570   Jan 2016   [Refereed]
Shimura T, Yamaguchi I, Terada H, Robert Svendsen E, Kunugita N
Journal of radiation research   56(3) 422-429   May 2015   [Refereed]
Akita M, Tak YS, Shimura T, Matsumoto S, Okuda-Shimizu Y, Shimizu Y, Nishi R, Saitoh H, Iwai S, Mori T, Ikura T, Sakai W, Hanaoka F, Sugasawa K
Scientific reports   5 10984   Jun 2015   [Refereed]
Fu H, Martin MM, Regairaz M, Huang L, You Y, Lin CM, Ryan M, Kim R, Shimura T, Pommier Y, Aladjem MI
Nature communications   6 6746   Apr 2015   [Refereed]
Sasatani M, Xu Y, Kawai H, Cao L, Tateishi S, Shimura T, Li J, Iizuka D, Noda A, Hamasaki K, Kusunoki Y, Kamiya K
PloS one   10(2) e0117845   2015   [Refereed]
Oji Y, Tatsumi N, Kobayashi J, Fukuda M, Ueda T, Nakano E, Saito C, Shibata S, Sumikawa M, Fukushima H, Saito A, Hojo N, Suzuki M, Hoshikawa T, Shimura T, Morii E, Oka Y, Hosen N, Komatsu K, Sugiyama H
Molecular carcinogenesis   54(12) 1758-1771   Nov 2014   [Refereed]
Shimura T, Kobayashi J, Komatsu K, Kunugita N
Oncogenesis   3 e132   Dec 2014   [Refereed]
Fukumoto M, Amanuma T, Kuwahara Y, Shimura T, Suzuki M, Mori S, Kumamoto H, Saito Y, Ohkubo Y, Duan Z, Sano K, Oguchi T, Kainuma K, Usami S, Kinoshita K, Lee I, Fukumoto M
Cancer science   105(10) 1351-1359   Oct 2014   [Refereed]
Shimura T, Noma N, Sano Y, Ochiai Y, Oikawa T, Fukumoto M, Kunugita N
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology   112(2) 302-307   Aug 2014   [Refereed]
Shimura T, Hamada N, Sasatani M, Kamiya K, Kunugita N
Cell cycle (Georgetown, Tex.)   13(8) 1248-1255   2014   [Refereed]
Shimura T, Fukumoto M, Kunugita N
Cell cycle (Georgetown, Tex.)   12(17) 2738-2743   Sep 2013   [Refereed]
Shimura T, Ochiai Y, Noma N, Oikawa T, Sano Y, Fukumoto M
Cell cycle (Georgetown, Tex.)   12(5) 773-782   Mar 2013   [Refereed]
Fukuda T, Kino Y, Abe Y, Yamashiro H, Kuwahara Y, Nihei H, Sano Y, Irisawa A, Shimura T, Fukumoto M, Shinoda H, Obata Y, Saigusa S, Sekine T, Isogai E, Fukumoto M
PloS one   8(1) e54312   2013   [Refereed]
Shimura T, Noma N, Oikawa T, Ochiai Y, Kakuda S, Kuwahara Y, Takai Y, Takahashi A, Fukumoto M
Oncogenesis   1 e12   Jun 2012   [Refereed]
Kuwahara Y, Oikawa T, Ochiai Y, Roudkenar MH, Fukumoto M, Shimura T, Ohtake Y, Ohkubo Y, Mori S, Uchiyama Y, Fukumoto M
Cell death & disease   2 e177   Jun 2011   [Refereed]
Shimura T, Kakuda S, Ochiai Y, Kuwahara Y, Takai Y, Fukumoto M
International journal of radiation oncology, biology, physics   80(2) 540-548   Jun 2011   [Refereed]
Activation of EGFR, AKT and ERK1/2 by exposure to tritiated water in human tumor cells.
Tsutomu Shimura
Fusion Science and Technology   60 1190-1192   2011   [Refereed]
Shimura T
Journal of radiation research   52(5) 539-544   2011   [Refereed]
Interactions of MCP1 with components of the replication machinery in mammalian cells.
Bronze-da-Rocha E, Lin CM, Shimura T, Aladjem MI
International journal of biological sciences   7(2) 193-208   Feb 2011   [Refereed]
Shimura T, Kakuda S, Ochiai Y, Nakagawa H, Kuwahara Y, Takai Y, Kobayashi J, Komatsu K, Fukumoto M
Oncogene   29(34) 4826-4837   Aug 2010   [Refereed]
Maruko A, Ohtake Y, Kawaguchi M, Kobayashi T, Baba T, Kuwahara Y, Nakagawa H, Shimura T, Fukumoto M, Ohkubo Y
Radiation research   173(5) 620-628   May 2010   [Refereed]
Kuwahara Y, Mori M, Oikawa T, Shimura T, Ohtake Y, Mori S, Ohkubo Y, Fukumoto M
Journal of radiation research   51(3) 297-302   2010   [Refereed]
Kuwahara Y, Li L, Baba T, Nakagawa H, Shimura T, Yamamoto Y, Ohkubo Y, Fukumoto M
Cancer science   100(4) 747-752   Apr 2009   [Refereed]
Nishizuka S, Ramalingam S, Spurrier B, Washburn FL, Krishna R, Honkanen P, Young L, Tsutomu S, Steeg PS, Austin J
Journal of proteome research   7(2) 803-808   Feb 2008   [Refereed]
Shimura T, Torres MJ, Martin MM, Rao VA, Pommier Y, Katsura M, Miyagawa K, Aladjem MI
Journal of molecular biology   375(4) 1152-1164   Jan 2008   [Refereed]
Adiga SK, Toyoshima M, Shiraishi K, Shimura T, Takeda J, Taga M, Nagai H, Kumar P, Niwa O
Oncogene   26(42) 6141-6149   Sep 2007   [Refereed]
Miao ZH, Player A, Shankavaram U, Wang YH, Zimonjic DB, Lorenzi PL, Liao ZY, Liu H, Shimura T, Zhang HL, Meng LH, Zhang YW, Kawasaki ES, Popescu NC, Aladjem MI, Goldstein DJ, Weinstein JN, Pommier Y
Cancer research   67(18) 8752-8761   Sep 2007   [Refereed]
Ramalingam S, Honkanen P, Young L, Shimura T, Austin J, Steeg PS, Nishizuka S
Cancer research   67(13) 6247-6252   Jul 2007   [Refereed]
Shimura T, Martin MM, Torres MJ, Gu C, Pluth JM, DeBernardi MA, McDonald JS, Aladjem MI
Journal of molecular biology   367(3) 665-680   Mar 2007   [Refereed]
Adiga SK, Toyoshima M, Shimura T, Takeda J, Uematsu N, Niwa O
Reproduction (Cambridge, England)   133(2) 415-422   Feb 2007   [Refereed]
Toyoshima M, Shimura T, Adiga SK, Taga M, Shiraishi K, Inoue M, Yuan ZM, Niwa O
Oncogene   24(20) 3229-3235   May 2005   [Refereed]
Shimura T, Toyoshima M, Taga M, Shiraishi K, Uematsu N, Inoue M, Niwa O
Radiation research   158(6) 735-742   Dec 2002   [Refereed]
Shiraishi K, Shimura T, Taga M, Uematsu N, Gondo Y, Ohtaki M, Kominami R, Niwa O
Radiation research   157(6) 661-667   Jun 2002   [Refereed]
Shimura T, Inoue M, Taga M, Shiraishi K, Uematsu N, Takei N, Yuan ZM, Shinohara T, Niwa O
Molecular and cellular biology   22(7) 2220-2228   Apr 2002   [Refereed]
Increased frequencies of gene and chromosome mutations after X-irradiation in mouse embryonal carcinoma cells transfected with the bcl-2 gene.
Taga M, Shiraishi K, Shimura T, Uematsu N, Oshimura M, Niwa O
Japanese journal of cancer research : Gann   91(10) 994-1000   Oct 2000   [Refereed]
Taga M, Shiraishi K, Shimura T, Uematsu N, Kato T, Nishimune Y, Aizawa S, Oshimura M, Niwa O
Journal of radiation research   41(3) 227-241   Sep 2000   [Refereed]
Shimizu N, Shimura T, Tanaka T
Mutation research   448(1) 81-90   Mar 2000   [Refereed]

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2009 - 2010    Investigator(s): Tsutomu SHIMURA
We have demonstrated that tumor radioresistance can be suppressed by down-regulation of AKT/GSK3beta/cyclin D1 pathway. Manipulation of cyclin D1 is useful to enhance the efficacy of radiotherapy.