論文

国際誌
2021年8月18日

Tree Shrew as an Emerging Small Animal Model for Human Viral Infection: A Recent Overview.

Viruses
  • Mohammad Enamul Hoque Kayesh
  • ,
  • Takahiro Sanada
  • ,
  • Michinori Kohara
  • ,
  • Kyoko Tsukiyama-Kohara

13
8
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/v13081641

Viral infection is a global public health threat causing millions of deaths. A suitable small animal model is essential for viral pathogenesis and host response studies that could be used in antiviral and vaccine development. The tree shrew (Tupaia belangeri or Tupaia belangeri chinenesis), a squirrel-like non-primate small mammal in the Tupaiidae family, has been reported to be susceptible to important human viral pathogens, including hepatitis viruses (e.g., HBV, HCV), respiratory viruses (influenza viruses, SARS-CoV-2, human adenovirus B), arboviruses (Zika virus and dengue virus), and other viruses (e.g., herpes simplex virus, etc.). The pathogenesis of these viruses is not fully understood due to the lack of an economically feasible suitable small animal model mimicking natural infection of human diseases. The tree shrew model significantly contributes towards a better understanding of the infection and pathogenesis of these important human pathogens, highlighting its potential to be used as a viable viral infection model of human viruses. Therefore, in this review, we summarize updates regarding human viral infection in the tree shrew model, which highlights the potential of the tree shrew to be utilized for human viral infection and pathogenesis studies.

リンク情報
DOI
https://doi.org/10.3390/v13081641
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34452505
ID情報
  • DOI : 10.3390/v13081641
  • PubMed ID : 34452505

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