論文

査読有り
2020年8月

Development of Bioreduction Labile Protecting Groups for the 2 '-Hydroxyl Group of RNA

ORGANIC LETTERS
  • Hisao Saneyoshi
  • ,
  • Kodai Nakamura
  • ,
  • Kazuma Terasawa
  • ,
  • Akira Ono

22
15
開始ページ
6006
終了ページ
6009
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/acs.orglett.0c02086
出版者・発行元
AMER CHEMICAL SOC

Protection and deprotection of the 2'-hydroxyl group of RNAs are critical for RNA-based drug discovery. This paper reports development of a bioreduction labile protecting group of the 2'-hydroxyl group in RNA. After the reduction of the nitro group in a chemical or enzymatic manner, the protecting groups were removed spontaneously. The attachment of electron-donating groups to the benzene ring or benzylic carbon enabled fast and controllable deprotection of the 2'-hydroxyl protecting group under physiological conditions.

リンク情報
DOI
https://doi.org/10.1021/acs.orglett.0c02086
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000562077400057&DestApp=WOS_CPL
ID情報
  • DOI : 10.1021/acs.orglett.0c02086
  • ISSN : 1523-7060
  • eISSN : 1523-7052
  • Web of Science ID : WOS:000562077400057

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