Papers

Peer-reviewed
Sep, 2020

Design and Synthesis of Protecting Groups for Pro-oligo Type Nucleic Acid-based Drugs

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN
  • Hisao Saneyoshi
  • ,
  • Akira Ono

Volume
78
Number
9
First page
886
Last page
893
Language
Japanese
Publishing type
Research paper (scientific journal)
DOI
10.5059/yukigoseikyokaishi.78.886
Publisher
SOC SYNTHETIC ORGANIC CHEM JPN

Oligonucleotide-based therapeutics, such as antisense oligonucleotides and small interfering RNAs (siRNAs), are fast emerging as the next generation of chemotherapeutics. However, a major issue for oligonucleotide-based therapeutics involves effective intracellular delivery of the active molecules into the cells. Several methods such as lipid nanoparticle encapsulation and conjugation of functional molecules have been reported. As an alternative approach, the use of pro-oligonucleotides (pro-oligos) offers several advantages, including improved enzymatic stability, thereby avoiding the need for transfection reagents for the delivery of oligonucleotides into cells. We have developed several bio-labile protecting groups for the pro-oligos. This article describes the design and synthesis of bio-labile protecting groups and their application to pro-oligo type molecules for the development of oligonucleotide therapeutics.

Link information
DOI
https://doi.org/10.5059/yukigoseikyokaishi.78.886
CiNii Articles
http://ci.nii.ac.jp/naid/130007898711
CiNii Books
http://ci.nii.ac.jp/ncid/AN0024521X
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000600514200006&DestApp=WOS_CPL
URL
http://id.ndl.go.jp/bib/030651920
ID information
  • DOI : 10.5059/yukigoseikyokaishi.78.886
  • ISSN : 0037-9980
  • CiNii Articles ID : 130007898711
  • CiNii Books ID : AN0024521X
  • Web of Science ID : WOS:000600514200006

Export
BibTeX RIS