論文

査読有り
2020年9月

プロオリゴ型核酸医薬を志向した保護基の開発研究

有機合成化学協会誌
  • 實吉 尚郎
  • ,
  • 小野 晶

78
9
開始ページ
886
終了ページ
893
記述言語
日本語
掲載種別
研究論文(学術雑誌)
DOI
10.5059/yukigoseikyokaishi.78.886
出版者・発行元
公益社団法人 有機合成化学協会

<p>Oligonucleotide-based therapeutics, such as antisense oligonucleotides and small interfering RNAs(siRNAs), are fast emerging as the next generation of chemotherapeutics. However, a major issue for oligonucleotide-based therapeutics involves effective intracellular delivery of the active molecules into the cells. Several methods such as lipid nanoparticle encapsulation and conjugation of functional molecules have been reported. As an alternative approach, the use of pro-oligonucleotides (pro-oligos) offers several advantages, including improved enzymatic stability, thereby avoiding the need for transfection reagents for the delivery of oligonucleotides into cells. We have developed several bio-labile protecting groups for the pro-oligos. This article describes the design and synthesis of bio-labile protecting groups and their application to pro-oligo type molecules for the development of oligonucleotide therapeutics.</p>

リンク情報
DOI
https://doi.org/10.5059/yukigoseikyokaishi.78.886
CiNii Articles
http://ci.nii.ac.jp/naid/130007898711
CiNii Books
http://ci.nii.ac.jp/ncid/AN0024521X
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000600514200006&DestApp=WOS_CPL
URL
http://id.ndl.go.jp/bib/030651920
ID情報
  • DOI : 10.5059/yukigoseikyokaishi.78.886
  • ISSN : 0037-9980
  • CiNii Articles ID : 130007898711
  • CiNii Books ID : AN0024521X
  • Web of Science ID : WOS:000600514200006

エクスポート
BibTeX RIS