1997年5月
Simple approach to optically active drimane sesquiterpenes based on enzymatic resolution
CHEMICAL & PHARMACEUTICAL BULLETIN
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- 巻
- 45
- 号
- 5
- 開始ページ
- 824
- 終了ページ
- 831
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1248/cpb.45.824
- 出版者・発行元
- PHARMACEUTICAL SOC JAPAN
When the beta-acyloxy esters (+/-)-10 and (+/-)-11 were exposed to the lipase OF-360 from Candida rugosa or immobilized lipase OF-360 in a water-saturated organic solvent, the hydrolyzed product (8aS)-6 was obtained in high chemical (40%) and optical (>99%ee) yields. The absolute structure of (8aS)-6 was confirmed by the fact that (8aS)-6 was converted into an authentic sample gamma-keto nitrile (8aS)-17. Treatment of the diol (+/-)-12 with isopropenyl acetate in the presence of the lipase Godo E-4 from Pseudomonas sp. provided the unchanged(8aR)-12 (89%ee) in 42% yield.
- リンク情報
- ID情報
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- DOI : 10.1248/cpb.45.824
- ISSN : 0009-2363
- CiNii Articles ID : 110003616578
- Web of Science ID : WOS:A1997XA82900011