論文

査読有り 国際誌
2020年10月

Limited frequency of malignant change in lobular endocervical glandular hyperplasia

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
  • Hisanori Kobara
  • ,
  • Tsutomu Miyamoto
  • ,
  • Hirofumi Ando
  • ,
  • Ryoichi Asaka
  • ,
  • Akiko Takatsu
  • ,
  • Ayumi Ohya
  • ,
  • Shiho Asaka
  • ,
  • Tanri Shiozawa

30
10
開始ページ
1480
終了ページ
1487
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1136/ijgc-2020-001612
出版者・発行元
BMJ PUBLISHING GROUP

Introduction Although lobular endocervical glandular hyperplasia is a benign disorder of the uterine cervix, its potential as a precursor of minimal deviation adenocarcinoma has been reported. However, the natural history of the disease and the frequency of malignant change are not fully understood. We evaluated the frequency of malignant change of clinical lobular endocervical glandular hyperplasia and explored useful parameters indicating malignant change. Methods The clinical courses of 175 patients with cervical multi-cystic lesions who visited Shinshu University Hospital between June 1995 and June 2019 were retrospectively analyzed. We examined the results of follow-up and outcomes of the patients diagnosed with lobular endocervical glandular hyperplasia and investigated the frequency of malignant transformation. Results Of the 175 patients, 15, 84, and 76 were clinically diagnosed with suspected malignancy, suspected lobular endocervical glandular hyperplasia, and suspected nabothian cyst, respectively. Of these patients, 69 patients with suspected lobular endocervical glandular hyperplasia were followed, and 12 underwent hysterectomy after a mean follow-up of 57.1 (range: 3-154) months due to lesion enlargement (increase in tumor diameter of >20%) and/or worsening cytology. Of these 12 patients, two had lobular endocervical glandular hyperplasia with atypia and one had minimal deviation adenocarcinoma. Of 69 patients, the rate of malignant change was 1.4% (1/69). The growth rates of the lesions for these three patients during follow-up were significantly higher than those of nine patients who underwent surgery with lobular endocervical glandular hyperplasia without atypia and 48 follow-up cases of suspected lobular endocervical glandular hyperplasia. The cut-off value of the growth rate suggesting malignant transformation was 38.1% (84.6% sensitivity and 100% specificity). Tumor size and cytology did not change in the remaining 57 cases continuing follow-up. Conclusion An increase in tumor size and worsening cytology are important parameters for detecting malignant transformation of lobular endocervical glandular hyperplasia during follow-up. However, the frequency of malignant change of this disease may be limited. These results suggest that conservative management may be an option for clinical lobular endocervical glandular hyperplasia.


リンク情報
DOI
https://doi.org/10.1136/ijgc-2020-001612
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32883699
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548537
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000576755300003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1136/ijgc-2020-001612
  • ISSN : 1048-891X
  • eISSN : 1525-1438
  • PubMed ID : 32883699
  • PubMed Central 記事ID : PMC7548537
  • Web of Science ID : WOS:000576755300003

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