Shiho Asaka

Profile Information

Affiliation: Director, Department of Laboratory Medicine, Nagano Children's Hospital
: Assistant professor, Department of Laboratory Medicine, Shinshu University Hospital

Degree: 医学博士(Mar, 2017, 信州大学)

ORCID ID: https://orcid.org/0000-0003-2697-114X
J-GLOBAL ID: 202101006274271576
researchmap Member ID: R000018719

Research Interests

Research Areas

Life sciences / Human pathology /

Research History

Apr, 2023 - Present

Director, Department of Laboratory Medicine, Nagano Children's Hospital
Jan, 2023 - Present

Assistant professor, Department of Laboratory Medicine, Shinshu University Hospital
Aug, 2020 - Dec, 2022

Medical Staff, Department of Laboratory Medicine, ShinSHu University Hospital
Jun, 2017 - Jun, 2020

Postdoctral research fellow, Department of Oncology, Johns Hopkins University School of Medicine
Oct, 2014 - May, 2017

Assistant professor, Department of Laboratory Medicine, Shinshu University School of Medicine

Education

Apr, 2013 - Mar, 2017

Department of Laboratory Medicine, Graduate School of Medicine, Shinshu University
Apr, 2001 - Mar, 2007

School of Medicine, Shinshu University

Awards

Papers

A preliminary study of IgG4 expression and its prognostic significance in oral squamous cell carcinoma.

Hironobu Fukuda, Takeshi Uehara, Tomoyuki Nakajima, Mai Iwaya, Shiho Asaka, Hiroshi Kurita

BMC cancer, 24(1) 294-294, Mar 4, 2024
Mucosal damage in pancreaticobiliary maljunction is stronger in the gallbladder than in the bile duct.

Masato Kamakura, Takeshi Uehara, Takashi Muraki, Mai Iwaya, Shiho Asaka, Tomoyuki Nakajima, Yugo Iwaya, Tadanobu Nagaya, Takahiro Yoshizawa, Akira Shimizu …

Pathology, research and practice, 253 155011-155011, Jan, 2024
Interleukin-6 Stromal Expression is Correlated with Epithelial-Mesenchymal Transition at Tumor Budding in Colorectal Cancer.

Takeshi Uehara, Koichi Sato, Mai Iwaya, Shiho Asaka, Tomoyuki Nakajima, Tadanobu Nagaya, Masato Kitazawa, Hiroyoshi Ota

International journal of surgical pathology, 10668969231177705-10668969231177705, Jun 12, 2023
ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer.

Ryo Kanai, Takeshi Uehara, Takahiro Yoshizawa, Masato Kamakura, Tomoyuki Nakajima, Yasuhiro Kinugawa, Mai Iwaya, Shiho Asaka, Masato Kitazawa, Tadanobu Nagaya …

BMC cancer, 23(1) 478-478, May 26, 2023
IgG4 expression and IgG4/IgG ratio in the tumour invasion front predict long-term outcomes for patients with intrahepatic cholangiocarcinoma.

Takahiro Yoshizawa, Takeshi Uehara, Mai Iwaya, Shiho Asaka, Tomoyuki Nakajima, Yasuhiro Kinugawa, Akira Shimizu, Koji Kubota, Tsuyoshi Notake, Hitoshi Masuo …

Pathology, 55(4) 508-513, Feb 3, 2023
High expression of LGR6 is a poor prognostic factor in esophageal carcinoma.

Takehito Ehara, Takeshi Uehara, Takahiro Yoshizawa, Yasuhiro Kinugawa, Tomoyuki Nakajima, Shota Kobayashi, Shiho Asaka, Mai Iwaya, Tadanobu Nagaya, Masato Kitazawa …

Pathology, research and practice, 242 154312-154312, Feb, 2023
ARID1A Regulates Progesterone Receptor Expression in Early Endometrial Endometrioid Carcinoma Pathogenesis

Shiho Asaka, Ying Liu, Zheng-Cheng Yu, Yohan Suryo Rahmanto, Motoki Ono, Ryoichi Asaka, Tsutomu Miyamoto, Ting-Tai Yen, Ayse Ayhan, Tian-Li Wang …

Modern Pathology, Feb, 2023 Peer-reviewedLead author
胎児型横紋筋腫類似の高分化異所性肉腫を有する卵巣癌肉腫の一例

成澤友里, 浅香志穂, 紺野沙織, 布麻里奈, 草間由紀子, 村元勤, 西澤千津恵, 小林弥生子, 大石善丈, 上原剛

日本病理学会会誌, 111(2) 106-106, Oct, 2022
PIM1 is a Poor Prognostic Factor for and Potential Therapeutic Target in Serous Carcinoma of the Endometrium.

Hodaka Takeuchi, Tsutomu Miyamoto, Chiho Fuseya, Ryoichi Asaka, Koichi Ida, Motoki Ono, Yasuhiro Tanaka, Manaka Shinagawa, Hirofumi Ando, Shiho Asaka …

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, Apr 12, 2022 Peer-reviewed
Correlation of LGR5 expression and clinicopathological features in intrahepatic cholangiocarcinoma.

Takahiro Yoshizawa, Takeshi Uehara, Mai Iwaya, Shiho Asaka, Shota Kobayashi, Tomoyuki Nakajima, Yasuhiro Kinugawa, Tadanobu Nagaya, Masato Kamakura, Akira Shimizu …

Pathology, research and practice, 232 153832-153832, Mar 3, 2022 Peer-reviewed
Usual Interstitial Pneumonia Pattern Interstitial Lung Disease Developed in a Patient with IgG4-related Chronic Sclerosing Sialadenitis: A Case Report.

Hiroshi Yamamoto, Masamichi Komatsu, Kei Sonehara, Yuichi Ikuyama, Kazuhisa Urushihata, Kazunari Tateishi, Yoshiaki Kitaguchi, Atsuhito Ushuiki, Shiho Asaka, Takeshi Uehara …

Internal medicine (Tokyo, Japan), 61(17) 2637-2642, Feb 8, 2022 Peer-reviewed
LGR5 expression and clinicopathological features of the invasive front in the fat infiltration area of pancreatic cancer.

Masato Kamakura, Takeshi Uehara, Mai Iwaya, Shiho Asaka, Shota Kobayashi, Tomoyuki Nakajima, Yasuhiro Kinugawa, Tadanobu Nagaya, Takahiro Yoshizawa, Akira Shimizu …

Diagnostic pathology, 17(1) 21-21, Feb 5, 2022 Peer-reviewed
Syndrome of Inappropriate Antidiuretic Hormone Secretion as the Initial Presentation in a Patient with Stage I Small-cell Lung Cancer.

Tomonobu Koizumi, Takashi Kobayashi, Shintaro Kanda, Toshirou Fukushima, Futoshi Muranaka, Kentaro Miura, Shiho Asaka

Internal medicine (Tokyo, Japan), 61(5) 709-713, 2022 Peer-reviewed
Clinicopathological and prognostic significance of immunophenotypic characterization of endocervical adenocarcinoma using CLDN18, CDH17, and PAX8 in association with HPV status.

Shiho Asaka, Tomoyuki Nakajima, Koichi Ida, Ryoichi Asaka, Chinatsu Kobayashi, Masayuki Ito, Tsutomu Miyamoto, Takeshi Uehara, Hiroyoshi Ota

Virchows Archiv : an international journal of pathology, 480(2) 269-280, Sep 28, 2021 Peer-reviewedLead authorCorresponding author
IL-6 expression helps distinguish Castleman's disease from IgG4-related disease in the lung.

Yasuhiro Kinugawa, Takeshi Uehara, Mai Iwaya, Shiho Asaka, Shota Kobayashi, Tomoyuki Nakajima, Masamichi Komatsu, Masanori Yasuo, Hiroshi Yamamoto, Hiroyoshi Ota

BMC pulmonary medicine, 21(1) 219-219, Jul 10, 2021 Peer-reviewed
Superiority of sucrase-isomaltase to CD10 for immunohistochemical detection of intestinal absorptive cell phenotype in differentiated-type gastric adenocarcinoma.

Hiroyoshi Ota, Masayuki Ito, Chinatsu Kobayashi, Shiho Asaka, Mai Iwaya, Takeshi Uehara

International journal of clinical and experimental pathology, 14(10) 1031-1037, 2021 Peer-reviewed
Genome-wide mutation analysis in precancerous lesions of endometrial carcinoma

Lihong Li, Pinli Yue, Qianqian Song, Ting-Tai Yen, Shiho Asaka, Tian-Li Wang, Anna L. Beavis, Amanda N. Fader, Yuchen Jiao, Guangwen Yuan …

JOURNAL OF PATHOLOGY, 253(1) 119-128, Jan, 2021 Peer-reviewed
Immunostaining With Immunoglobulin G Subclass Antibody Cocktail for Diagnosis of Type 1 Autoimmune Pancreatitis

Rie Nakata, Takeshi Uehara, Mai Iwaya, Shiho Asaka, Shota Kobayashi, Mitsutoshi Sugano, Kayoko Higuchi, Yukiko Kusama, Koh Nakazawa, Masato Nakaguro …

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 28(8) 844-849, Dec, 2020 Peer-reviewed
Limited frequency of malignant change in lobular endocervical glandular hyperplasia

Hisanori Kobara, Tsutomu Miyamoto, Hirofumi Ando, Ryoichi Asaka, Akiko Takatsu, Ayumi Ohya, Shiho Asaka, Tanri Shiozawa

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 30(10) 1480-1487, Oct, 2020 Peer-reviewed
Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers

Yao-An Shen, Jiaxin Hong, Ryoichi Asaka, Shiho Asaka, Fang-Chi Hsu, Yohan Suryo Rahmanto, Jin-Gyoung Jung, Yu-Wei Chen, Ting-Tai Yen, Alicja Tomaszewski …

CANCER RESEARCH, 80(20) 4514-4526, Oct, 2020 Peer-reviewed

Misc.

特発性全身性後天性無汗症は汗腺暗細胞の脱顆粒が顕著に生じ、血清のCEAが上昇する(AIGA demonstrates marked degranulation of dark cells in eccrine gland and elevated CEA in serum)

佐野健司, 上原剛, 浅香志穂, 荒木信之, 朝比奈正人

日本病理学会会誌, 106(1) 476-476, Mar, 2017
Validation of a Rapid Point-of-Care Test to Detect Epidermal Growth Factor Receptor Gene Mutations in Patients with Lung Cancer by Using Cell-Free DNA Supernatants

Shiho Asaka, Akihiko Yoshizawa

MODERN PATHOLOGY, 30 472A-472A, Feb, 2017
IgA腎症と腎病変の合併を認めた血管免疫芽球性T細胞リンパ腫(AITL)の1例

酒井慧, 原田侑典, 浅香志穂

日本腎臓学会誌, 57(6) 985-985, Aug, 2015
A Novel High-Speed Droplet-Polymerase Chain Reaction Can Detect Epidermal Growth Factor Receptor Gene Mutation in Non-Small Cell Lung Cancer in Less Than 10 Minutes

Shiho Asaka, Akihiko Yoshizawa, Kazuyuki Matsuda, Akemi Yamaguchi, Yukihiro Kobayashi, Rie Nakata, Zhang Meng, Mitsutoshi Sugano, Takayuki Honda

MODERN PATHOLOGY, 28 471A-472A, Feb, 2015
胸腔内に進展した胸壁原発low grade fibromyxoid sarcomaの1切除例

奥村征大, 江口隆, 小林宣隆, 齋藤学, 兵庫谷章, 濱中一敏, 椎名隆之, 藏井誠, 吉田和夫, 天野純 …

日本臨床外科学会雑誌, 71(増刊) 720-720, Oct, 2010
術前に肝細胞癌と診断された肝reactive lymphoid hyperplasiaの1例

鈴木史恭, 横山隆秀, 秋田眞吾, 内川裕司, 本山博章, 清水明, 中田岳成, 小林聡, 三輪史郎, 黒住昌弘 …

ENDOSCOPIC FORUM for digestive disease, 26(1) 87-87, Jun, 2010
上皮内扁平上皮癌病巣へのPagetoid spreadを伴った食道内分泌細胞癌の1例

福島万奈, 浅香志穂, 遠藤真紀, 浅野功治, 小林実喜子, 上原剛, 下条久志, 佐野健司, 太田浩良, 本田孝行

日本病理学会会誌, 99(1) 258-258, Mar, 2010
結核性腹膜炎として発症し、急速な経過で死亡した粟粒結核の1剖検例

浅香志穂, 福島万奈, 増本純也, 遠藤真紀, 佐野健司, 金井信一郎, 中山淳, 本田孝行

日本病理学会会誌, 99(1) 335-335, Mar, 2010

Professional Memberships

Research Projects

Analysis of tumor microenvironment in cell lineage-based subtypes of endocervical adenocarcinoma

Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Significance of alphaGlcNAc expression status in human tumors

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2019

Yamanoi Kazuhiro, Nakayama Jun, Fujii Chifumi, Ohya Ayumu, Ida Koichi, Ishii Keiko, Asaka Shiho, Shimojo Hisashi, Miyamoto Tsutomu, Shiozawa Tanri
HPV infection and genomic alteration in endocervical glandular lesion

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2018
Diagnostic markers of glandular lesion and their precursor lesions of uterine cervix

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

OTA Hiroyoshi, ASAKA Shiho, KUBOTA Seiko
子宮頚部腺癌の層別化治療に向けた細胞系列特異マーカーによる免疫表現型分類法の確立

第29回研究助成金, 公益財団法人黒住医学研究振興財団

浅香志穂

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