2020年9月21日
RNA Sequencing Identifies a Common Physiology in Vancomycin- and Ciprofloxacin-Tolerant Staphylococcus aureus Induced by ileS Mutations.
Antimicrobial agents and chemotherapy
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 64
- 号
- 10
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1128/AAC.00827-20
Little is known about the mechanisms by which ileS mutations induce vancomycin tolerance in Staphylococcus aureus This study showed that transcriptome profiles were similar in vancomycin-tolerant mutants and the IleRS-inhibitor-treated parent. Notably, ileS and relA, which induce a stringent response, were upregulated. The same mechanism was responsible for cross-tolerance to vancomycin and ciprofloxacin. These findings suggest that the accumulation of uncharged isoleucyl-tRNA following ileS mutations in S. aureus was responsible for drug tolerance.
- リンク情報
- ID情報
-
- DOI : 10.1128/AAC.00827-20
- PubMed ID : 32690649
- PubMed Central 記事ID : PMC7508618