Satoko Arai

Profile Information

Affiliation: Chief Scientist, Vice Director, Department of Molecular Biomedicine for Pathogenesis, The Insitute for AIM Medicine

Other name(s) (e.g. nickname): Satoko Arai
J-GLOBAL ID: 201801019570926382
researchmap Member ID: B000316607

External link: https://iamaim.jp/

Research Interests

Research Areas

Major Research History

Jan, 2016 - Mar, 2023

Associate Professor, Graduate School of Medicine Center for Disease Biology and Integrative Medicine, The University of Tokyo

Major Education

Apr, 2001 - Mar, 2004

Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Apr, 1999 - Mar, 2001

Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Apr, 1997 - Mar, 1999

The University of Tokyo

Awards

Major Papers

Cryo-EM reveals structural basis for human AIM/CD5L recognition of polymeric immunoglobulin M

Qu Chen, Kazuhiro Ishii, Haruka Mori, Akemi Nishijima, Satoko Arai, Toru Miyazaki, Peter B. Rosenthal

Nature Communications, Oct 30, 2024 Peer-reviewedCorresponding author
AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke.

Natsumi Maehara, Kaori Taniguchi, Ami Okuno, Hideaki Ando, Aika Hirota, Zhiheng Li, Ching-Ting Wang, Satoko Arai, Toru Miyazaki

Cell reports, 36(11) 109693-109693, Sep 14, 2021 Peer-reviewedCorresponding author
The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein.

Hiramoto E, Tsutsumi A, Suzuki R, Matsuoka S, Arai S, Kikkawa M, Miyazaki T

Science advances, 4(10) eaau1199, Oct, 2018 Peer-reviewedCorresponding author
Impact of feline AIM on the susceptibility of cats to renal disease

Ryoichi Sugisawa, Emiri Hiramoto, Shigeru Matsuoka, Satomi Iwai, Ryosuke Takai, Tomoko Yamazaki, Nobuko Mori, Yuki Okada, Naoki Takeda, Ken-ichi Yamamura …

SCIENTIFIC REPORTS, 6 35251-35251, Oct, 2016 Peer-reviewed
Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice

Satoko Arai, Kento Kitada, Tomoko Yamazaki, Ryosuke Takai, Xizhong Zhang, Yoji Tsugawa, Ryoichi Sugisawa, Ayaka Matsumoto, Mayumi Mori, Yasunori Yoshihara …

NATURE MEDICINE, 22(2) 183-193, Feb, 2016 Peer-reviewedLead author
Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells

Satoko Arai, Natsumi Maehara, Yoshihiro Iwamura, Shin-ichiro Honda, Katsuhiko Nakashima, Toshihiro Kai, Masato Ogishi, Kumiko Morita, Jun Kurokawa, Mayumi Mori …

CELL REPORTS, 3(4) 1187-1198, Apr, 2013 Peer-reviewedLead author

Major Misc.

【生物と腎臓】ペットと腎臓病猫の腎不全の治療

新井郷子, 宮崎徹

腎臓, 43 27-32, Mar, 2021
IgMは正五角形か? 電子顕微鏡と単粒子解析が解き明かした真実

新井郷子, 平本絵美莉, 包明久, 吉川雅英, 宮崎徹

糖尿病・内分泌代謝科, 50(3) 203-210, Mar, 2020
【免疫系を介したシステム連関:恒常性の維持と破綻】免疫と代謝 IgMによる血中タンパク質AIMの活性制御と疾患とのかかわり

新井郷子, 宮崎徹

生体の科学, 70(2) 148-154, Apr, 2019
血中タンパク質AIMによる体内のスカベンジングシステム

新井郷子, 宮崎徹

感染・炎症・免疫, 47(2) 98-107, Jul, 2017

Major Presentations

Role of phagocytic mechanisms in inflammatory tissue resilience and its application to disease therapy

Satoko Arai

The 96th Annual Meeting of the Japan Biochemical Society, Nov 1, 2023
Therapeutic and diagnostic impacts of AIM on refractory chronic diseases

Satoko Arai

The 100th Anniversary Annual Meeting of the Physiological Society of Japan, Feb 15, 2023 Invited
A role of the phagocytic removal system in resolution of inflammation and its therapeutic implication

Satoko Arai

Dec 7, 2022

Professional Memberships

2023 - Present

The Japanese Biochemical Society
Jul, 2011 - Present

Japan Society for Immunology
Aug, 2005 - Present

The Molecular Biology Society Japan

Major Research Projects

重症肺感染症における宿主防御応答向上のメカニズム解明

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2023 - Mar, 2026

新井郷子
Elucidation of the roles of restorative macrophages in inflammatory tissue resilience

Grants-in-Aid for Scientific Research, Grant-in-Aid for Transformative Research Areas (B), Japan Society for the Promotion of Science, Aug, 2021 - Mar, 2024
食細胞機構を用いた視機能劣化（アイフレイル）および眼疾患の制御

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2023

新井郷子, 相原一
Investigation of roles of circulating protein AIM in chronic kidney disease and its therapeutic application

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Arai Satoko, ITO yasuhiko
Development of prophylaxis and therapy system for metabolic stmdorome by regulation of AIM function

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

ARAI Satoko, MIYAZAKI Toru
Analysis for hematopoiesis and hematologic diseases by L3MBTL1 conditional knockout mice.

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2010 - 2011

ARAI Satoko
新しいポリコーム分子MBT-1による白血病制御を目指して

科学研究費助成事業若手研究(B), 若手研究(B), 日本学術振興会, 2006 - 2007

新井郷子

Profile Information

Research Interests

Research Areas

Major Research History

Major Education

Awards

Major Papers

Major Misc.

Major Presentations

Professional Memberships

Major Research Projects

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