Satoshi Okada


Satoshi Okada

J-GLOBAL         Last updated: Jul 1, 2019 at 22:42
 
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Name
Satoshi Okada
Nickname
Satoshi Okada
Affiliation
Hiroshima University
Degree
Ph.D.(Hiroshima University)
Research funding number
80457241
ORCID ID
0000-0002-4622-5657

Research Areas

 
 

Academic & Professional Experience

 
Jun 2015
 - 
Today
Lecturer, Department of Pediatrics, Graduate School of Biomedical & Health Sciencies
 
Mar 2010
 - 
Aug 2013
Postdoctoral associate, St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University
 
Apr 1999
 - 
Mar 2000
Internship, Department of Pediatrics, Hiroshima University Hospital
 
Jun 2009
 - 
May 2015
Assistant professor, Department of Pediatrics, Hiroshima University Hospital
 
Jun 2004
 - 
May 2009
Medical staff, Department of Pediatrics, Hiroshima University Hospital
 
Nov 2001
 - 
May 2004
Medical staff, Pediatrics, Chugoku Rousai Hospital
 
Apr 2000
 - 
Oct 2001
Medical staff, Pediatrics, Hiroshima Red Cross Hospital & Atomic Bomb Survivors Hospital
 

Education

 
Apr 2004
 - 
Sep 2007
Graduate School of Biomedical Science, Hiroshima University
 
Apr 1993
 - 
Mar 1999
School of Medicine, Faculty of Medicine, The University of Tokushima
 

Awards & Honors

 
Nov 2018
Phoenix Outstanding Researcher Award, Hiroshima University
 

Published Papers

 
Niihori T, Nagai K, Fujita A, Ohashi H, Okamoto N, Okada S, Harada A, Kihara H, Arbogast T, Funayama R, Shirota M, Nakayama K, Abe T, Inoue SI, Tsai IC, Matsumoto N, Davis EE, Katsanis N, Aoki Y
American journal of human genetics      May 2019   [Refereed]
We reported four de novo RRAS2 variants in three individuals with Noonan syndrome. RRAS2 is a member of the RAS subfamily and is ubiquitously expressed. Three variants, c.70_78dup (p.Gly24_Gly26dup), c.216A>T (p.Gln72His), and c.215A>T (p.Gln72Leu...
Rosain J, Kong XF, Martinez-Barricarte R, Oleaga-Quintas C, Ramirez-Alejo N, Markle J, Okada S, Boisson-Dupuis S, Casanova JL, Bustamante J
Immunology and cell biology   97(4) 360-367   Apr 2019   [Refereed]
Mendelian susceptibility to mycobacterial disease (MSMD) is caused by inborn errors of IFN‐γ immunity. Since 1996, disease‐causing mutations have been found in 11 genes, which, through allelic heterogeneity, underlie 21 different genetic disorders...
Henrickson SE, Dolan JG, Forbes LR, Vargas-Hernández A, Nishimura S, Okada S, Kersun LS, Brodeur GM, Heimall JR
Frontiers in pediatrics   7 160   Apr 2019   [Refereed]
In this report, we describe a novel T437N STAT1 mutation found in a mother and 3 of her 4 children which we demonstrate yields gain-of-function. All of the four patients with the T437N STAT1 mutation experienced lymphadenopathy. However, two of th...
Kumaki E, Tanaka K, Imai K, Aoki-Nogami Y, Ishiguro A, Okada S, Kanegane H, Ishikawa F, Morio T
International journal of hematology   109(4) 382-389   Apr 2019   [Refereed]
Mutation in the gene encoding tRNA nucleotidyl transferase, CCA-adding 1 (TRNT1), results in a disorder that features sideroblastic anemia, B-cell immunodeficiency, periodic fever, and developmental delay. To date, it has remained unclear how defe...
Boisson B, Honda Y, Ajiro M, Bustamante J, Bendavid M, Gennery AR, Kawasaki Y, Ichishima J, Osawa M, Nihira H, Shiba T, Tanaka T, Chrabieh M, Bigio B, Hur H, Itan Y, Liang Y, Okada S, Izawa K, Nishikomori R, Ohara O, Heike T, Abel L, Puel A, Saito MK, Casanova JL, Hagiwara M, Yasumi T
The Journal of clinical investigation   129(2) 583-597   Feb 2019   [Refereed]
X-linked dominant incontinentia pigmenti (IP) and X-linked recessive anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) are caused by loss-of-function and hypomorphic IKBKG (also known as NEMO) mutations, respectively. We describe a Eu...
Schwab C, Gabrysch A, Olbrich P, Patiño V, Warnatz K, Wolff D, Hoshino A, Kobayashi M, Imai K, Takagi M, Dybedal I, Haddock JA, Sansom D, Lucena JM, Seidl M, Schmitt-Gräff A, Reiser V, Emmerich F, Frede N, Bulashevska A, Salzer U, Schubert D, Hayakawa S, Okada S, Kanariou M, Kucuk ZY, Chapdelaine H, Petruzelkova L, Sumnik Z, Sediva A, Slatter M, Arkwright PD, Cant A, Lorenz HM, Giese T, Lougaris V, Plebani A, Price C, Sullivan KE, Moutschen M, Litzman J, Freiberger T, van de Veerdonk FL, Recher M, Albert MH, Hauck F, Seneviratne S, Schmid JP, Kolios A, Unglik G, Klemann C, Speckmann C, Ehl S, Leichtner A, Blumberg R, Franke A, Snapper S, Zeissig S, Cunningham-Rundles C, Giulino-Roth L, Elemento O, Dückers G, Niehues T, Fronkova E, Kanderová V, Platt CD, Chou J, Chatila T, Geha R, McDermott E, Bunn S, Kurzai M, Schulz A, Alsina L, Casals F, Deyà-Martinez A, Hambleton S, Kanegane H, Taskén K, Neth O, Grimbacher B
The Journal of allergy and clinical immunology   142(6) 1932-1946   Dec 2018   [Refereed]
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a negative immune regulator. Heterozygous CTLA4 germline mutations can cause a complex immune dysregulation syndrome in human subjects. We identified 133 subjects from 54 unrelated families carrying 45 ...
Martínez-Barricarte R, Markle JG, Ma CS, Deenick EK, Ramírez-Alejo N, Mele F, Latorre D, Mahdaviani SA, Aytekin C, Mansouri D, Bryant VL, Jabot-Hanin F, Deswarte C, Nieto-Patlán A, Surace L, Kerner G, Itan Y, Jovic S, Avery DT, Wong N, Rao G, Patin E, Okada S, Bigio B, Boisson B, Rapaport F, Seeleuthner Y, Schmidt M, Ikinciogullari A, Dogu F, Tanir G, Tabarsi P, Bloursaz MR, Joseph JK, Heer A, Kong XF, Migaud M, Lazarov T, Geissmann F, Fleckenstein B, Arlehamn CL, Sette A, Puel A, Emile JF, van de Vosse E, Quintana-Murci L, Di Santo JP, Abel L, Boisson-Dupuis S, Bustamante J, Tangye SG, Sallusto F, Casanova JL
Science immunology   3(30) eaau6759   Dec 2018   [Refereed]
We report patients with autosomal recessive, complete IL-12Rβ2 or IL-23R deficiency, lacking responses to IL-12 or IL-23 only, all of whom, unexpectedly, display mycobacteriosis without candidiasis. We show that αβ T, γδ T, B, NK, ILC1, and ILC2 c...
Ishii T, Adachi M, Takasawa K, Okada S, Kamasaki H, Kubota T, Kobayashi H, Sawada H, Nagasaki K, Numakura C, Harada S, Minamitani K, Sugihara S, Tajima T
Hormone research in paediatrics   89(3) 166-171   Nov 2018   [Refereed]
We aimed to evaluate the incidence and characteristics of adrenal crisis in Japanese children with 21-hydroxylase deficiency (21-OHD). We conducted a retrospective nationwide survey for the councilors of the Japanese Society for Pediatric Endocrin...
Chelisa Cardinez, Bahar Miraghazadeh, Kay Tanita, Elizabeth da Silva, Akihiro Hoshino, Satoshi Okada, Rochna Chand, Takaki Asano, Miyuki Tsumura, Kenichi Yoshida, Hidenori Ohnishi, Zenichiro Kato, Masahide Yamazaki, Yusuke Okuno, Satoru Miyano, Seiji Kojima, Seishi Ogawa, T. Daniel Andrews, Matthew A. Field, Gaetan Burgio, Tomohiro Morio, Carola G. Vinuesa, Hirokazu Kanegane, Matthew C. Cook
The Journal of Experimental Medicine   215(11) 2715-2724   Nov 2018   [Refereed]
We identified two separate kindreds with a novel heterozygous de novo IKBKB missense mutation (c.607G>A) in whom probands presented with immune dysregulation, combined T and B cell deficiency, inflammation, and epithelial defects. IKBKB encodes IK...
Egg D, Schwab C, Gabrysch A, Arkwright PD, Cheesman E, Giulino-Roth L, Neth O, Snapper S, Okada S, Moutschen M, Delvenne P, Pecher AC, Wolff D, Kim YJ, Seneviratne S, Kim KM, Kang JM, Ojaimi S, McLean C, Warnatz K, Seidl M, Grimbacher B
Frontiers in immunology   9 2012   Sep 2018   [Refereed]
Heterozygous germline mutations in CTLA4 can cause an immune dysregulation syndrome. Clinical manifestations and details of the clinical history were assessed in a worldwide cohort of 184 CTLA4 mutation carriers. Whenever a malignancy was reported...
Asano Takaki, Okada Satoshi, Tsumura Miyuki, Yeh Tzu-Wen, Mitsui-Sekinaka Kanako, Tsujita Yuki, Ichinose Youjiro, Shimada Akira, Hashimoto Kunio, Wada Taizo, Imai Kohsuke, Ohara Osamu, Morio Tomohiro, Nonoyama Shigeaki, Kobayashi Masao
FRONTIERS IN IMMUNOLOGY   9 568   Apr 2018   [Refereed]
Activated PI3Kδ syndrome (APDS) is a primary immunodeficiency characterized by recurrent respiratory tract infections, lymphoproliferation, and defective IgG production. We examined the AKT phosphorylation of peripheral blood lymphocytes and monoc...
Zhang SY, Clark NE, Freije CA, Pauwels E, Taggart AJ, Okada S, Mandel H, Garcia P, Ciancanelli MJ, Biran A, Lafaille FG, Tsumura M, Cobat A, Luo J, Volpi S, Zimmer B, Sakata S, Dinis A, Ohara O, Garcia Reino EJ, Dobbs K, Hasek M, Holloway SP, McCammon K, Hussong SA, DeRosa N, Van Skike CE, Katolik A, Lorenzo L, Hyodo M, Faria E, Halwani R, Fukuhara R, Smith GA, Galvan V, Damha MJ, Al-Muhsen S, Itan Y, Boeke JD, Notarangelo LD, Studer L, Kobayashi M, Diogo L, Fairbrother WG, Abel L, Rosenberg BR, Hart PJ, Etzioni A, Casanova JL
Cell   172(5) 952-965.e18   Feb 2018   [Refereed]
We report bi-allelic DBR1 mutations in unrelated patients with brainstem infection due to HSV1, influenza virus, or norovirus. DBR1 encodes the only known RNA lariat debranching enzyme. We show that DBR1 expression is ubiquitous, but strongest in ...
Jennifer W. Leiding, Satoshi Okada, David Hagin, Mario Abinun, Anna Shcherbina, Dmitry N. Balashov, Vy H.D. Kim, Adi Ovadia, Stephen L. Guthery, Michael Pulsipher, Desa Lilic, Lisa A. Devlin, Sharon Christie, Mark Depner, Sebastian Fuchs, Annet van Royen-Kerkhof, Caroline Lindemans, Aleksandra Petrovic, Kathleen E. Sullivan, Nancy Bunin, Sara Sebnem Kilic, Fikret Arpaci, Oscar de la Calle-Martin, Laura Martinez-Martinez, Juan Carlos Aldave, Masao Kobayashi, Teppei Ohkawa, Kohsuke Imai, Akihiro Iguchi, Chaim M. Roifman, Andrew R. Gennery, Mary Slatter, Hans D. Ochs, Tomohiro Morio, Troy R. Torgerson
Journal of Allergy and Clinical Immunology   141(2) 704-717.e5   Feb 2018   [Refereed]
Gain-of-function (GOF) mutations in STAT1 cause susceptibility to a range of infections, autoimmunity, immune dysregulation, and combined immunodeficiency. Disease manifestations can be mild or severe and life-threatening. We aggregated the worldw...
Kanegane H, Hoshino A, Okano T, Yasumi T, Wada T, Takada H, Okada S, Yamashita M, Yeh TW, Nishikomori R, Takagi M, Imai K, Ochs HD, Morio T
Allergology international : official journal of the Japanese Society of Allergology   67(1) 43-54   Jan 2018   [Refereed]
Flow cytometry can evaluate specific cell populations and subpopulations, cell surface, intracellular and intranuclear proteins, biologic effects associated with specific immune defects, and certain functional immune characteristics, each being us...
Tajima G, Hara K, Tsumura M, Kagawa R, Okada S, Sakura N, Maruyama S, Noguchi A, Awaya T, Ishige M, Ishige N, Musha I, Ajihara S, Ohtake A, Naito E, Hamada Y, Kono T, Asada T, Sasai H, Fukao T, Fujiki R, Ohara O, Bo R, Yamada K, Kobayashi H, Hasegawa Y, Yamaguchi S, Takayanagi M, Hata I, Shigematsu Y, Kobayashi M
Molecular genetics and metabolism   122(3) 67-75   Nov 2017   [Refereed]
Carnitine palmitoyltransferase (CPT) II deficiency is one of the most common forms of mitochondrial fatty acid oxidation disorder (FAOD). However, newborn screening (NBS) for this potentially fatal disease has not been established partly because r...
Onodera Rie, Kurita Emi, Taniguchi Kikuyo, Karakawa Shuhei, Okada Satoshi, Kihara Hirotaka, Fujii Teruhisa, Kobayashi Masao
Transfusion   57(11) 2586-2594   Nov 2017   [Refereed]
Anti-human neutrophil antigen (HNA) antibodies have been implicated in the development of neonatal alloimmune neutropenia (NAN) and autoimmune neutropenia (AIN). We developed a new method, the extracted granulocyte antigen immunofluorescence assay...
Kitaoka T, Tajima T, Nagasaki K, Kikuchi T, Yamamoto K, Michigami T, Okada S, Fujiwara I, Kokaji M, Mochizuki H, Ogata T, Tatebayashi K, Watanabe A, Yatsuga S, Kubota T, Ozono K
Clinical endocrinology   87(1) 10-19   Jul 2017   [Refereed]
Hypophosphatasia (HPP) is a rare skeletal disease characterized by hypomineralization and low alkaline phosphatase activity. Asfotase alfa (AA) has been recently developed to treat HPP complications. This study evaluated its safety and efficacy in...
Kagawa Reiko, Fujiki Ryoji, Tsumura Miyuki, Sakata Sonoko, Nishimura Shiho, Itan Yuval, Kong Xiao-Fei, Kato Zenichiro, Ohnishi Hidenori, Hirata Osamu, Saito Satoshi, Ikeda Maiko, El Baghdadi Jamila, Bousfiha Aziz, Fujiwara Kaori, Oleastro Matias, Yancoski Judith, Perez Laura, Danielian Silvia, Ailal Fatima, Takada Hidetoshi, Hara Toshiro, Puel Anne, Boisson-Dupuis Stephanie, Bustamante Jacinta, Casanova Jean-Laurent, Ohara Osamu, Okada Satoshi, Kobayashi Masao
Journal of Allergy and Clinical Immunology   140(1) 232-241   Jul 2017   [Refereed]
Germline heterozygous mutations in human signal transducer and activator of transcription 1 (STAT1) can cause loss of function (LOF), as in patients with Mendelian susceptibility to mycobacterial diseases, or gain of function (GOF), as in patients...
Hoshino Akihiro, Okada Satoshi, Yoshida Kenichi, Nishida Naonori, Okuno Yusuke, Ueno Hiroo, Yamashita Motoi, Okano Tsubasa, Tsumura Miyuki, Nishimura Shiho, Sakata Sonoko, Kobayashi Masao, Nakamura Haruna, Kamizono Junji, Mitsui-Sekinaka Kanako, Ichimura Takuya, Ohga Shouichi, Nakazawa Yozo, Takagi Masatoshi, Imai Kohsuke, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Ogawa Seishi, Kojima Seiji, Nonoyama Shigeaki, Morio Tomohiro, Kanegane Hirokazu
Journal of Allergy and Clinical Immunology   140(1) 223-231   Jul 2017   [Refereed]
Ikaros, which is encoded by IKZF1, is a transcriptional factor that play a critical role in hematopoiesis. Somatic IKZF1 alterations are known to be involved in the pathogenesis of leukemia in human subjects. Recently, immunodeficiency caused by g...
Eslami Narges, Tavakol Marzieh, Mesdaghi Mehrnaz, Gharegozlou Mohammad, Casanova Jean-Laurent, Puel Anne, Okada Satoshi, Arshi Saba, Bemanian Mohammad Hassan, Fallahpour Morteza, Molatefi Rasool, Seif Farhad, Zoghi Samaneh, Rezaei Nima, Nabavi Mohammad
Acta Microbiologica Et Immunologica Hungarica   64(2) 191-201   Jun 2017   [Refereed]
Heterozygous gain-of-function (GOF) mutations in the signal transducer and activator of transcription 1 (STAT1) have increasingly been identified as a genetic cause of autosomal-dominant (AD) chronic mucocutaneous candidiasis (CMC). In this articl...
Fujiki R, Hijikata A, Shirai T, Okada S, Kobayashi M, Ohara O
The Journal of biological chemistry   292(15) 6240-6254   Apr 2017   [Refereed]
Gain-of-function (GOF) mutations in the STAT1 gene are critical for the onset of chronic mucocutaneous candidiasis (CMC) disease. We investigated the structural features of STAT1 GOF residues to better understand the impact of these pathogenic mut...
Sakata S, Okada S, Aoyama K, Hara K, Tani C, Kagawa R, Utsunomiya-Nakamura A, Miyagawa S, Ogata T, Mizuno H, Kobayashi M
Frontiers in genetics   8 210   2017   [Refereed]
We report a Japanese female patient presenting with classic features of CHARGE syndrome, including choanal atresia, growth and development retardation, ear malformations, genital anomalies, multiple endocrine deficiency, and unilateral facial nerv...
Hayakawa S, Ohno N, Okada S, Kobayashi M.
Clinical and Experimental Immunology   190(2) 268-279   2017   [Refereed]
Regulatory T cells (Tregs) control immune responses by suppressing various inflammatory cells. We examined the number and phenotype of Tregs during the neonatal period in 49 newborn babies. Tregs were characterized by flow cytometry using cord blo...
Nakamura-Utsunomiya Akari, Hiyama Takeshi Y, Okada Satoshi, Noda Masaharu, Kobayashi Masao
Clinical Pediatric Endocrinology   26(4) 197-205   2017   [Refereed]
Adipsic hypernatremia is a rare disease presenting as persistent hypernatremia with disturbance of thirst regulation and hypothalamic dysfunction. As a result of congenital disease, tumors, or inflammation, most cases are accompanied by structural...
Nagasaki Keisuke, Kubota Takuo, Kobayashi Hironori, Sawada Hirotake, Numakura Chikahiko, Harada Shohei, Takasawa Kei, Minamitani Kanshi, Ishii Tomohiro, Okada Satoshi, Kamasaki Hotaka, Sugihara Shigetaka, Adachi Masanori, Tajima Toshihiro
Clinical Pediatric Endocrinology   26(4) 207-213   2017   [Refereed]
Septo-optic dysplasia (SOD) is a congenital anomaly in which agenesis of the septum pellucidum and optic nerve hypoplasia are accompanied by hypopituitarism. Typically, the symptoms develop in 3 organs, the brain, eyes, and pituitary, and approxim...
Utsumi Takanori, Okada Satoshi, Izawa Kazushi, Honda Yoshitaka, Nishimura Gen, Nishikomori Ryuta, Okano Rika, Kobayashi Masao
Frontiers in Endocrinology   8 157   2017   [Refereed]
Spondyloenchondrodysplasia (SPENCD) is an autosomal recessive skeletal dysplasia caused by loss of function mutations in acid phosphatase 5, tartrate resistant (ACP5). Hypomorphic ACP5 mutations impair endochondral bone growth and create an interf...
Levy Romain, Okada Satoshi, Beziat Vivien, Moriya Kunihiko, Liu Caini, Chai Louis Yi Ann, Migaud Melanie, Hauck Fabian, Al Ali Amein, Cyrus Cyril, Vatte Chittibabu, Patiroglu Turkan, Unal Ekrem, Ferneiny Marie, Hyakuna Nobuyuki, Nepesov Serdar, Oleastro Matias, Ikinciogullari Aydan, Dogu Figen, Asano Takaki, Ohara Osamu, Yun Ling, Della Mina Erika, Bronnimann Didier, Itan Yuval, Gothe Florian, Bustamante Jacinta, Boisson-Dupuis Stephanie, Tahuil Natalia, Aytekin Caner, Salhi Aicha, Al Muhsen Saleh, Kobayashi Masao, Toubiana Julie, Abel Laurent, Li Xiaoxia, Camcioglu Yildiz, Celmeli Fatih, Klein Christoph, AlKhater Suzan A., Casanova Jean-Laurent, Puel Anne
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   113(51) E8277-E8285   Dec 2016   [Refereed]
Tajima Go, Hara Keiichi, Tsumura Miyuki, Kagawa Reiko, Okada Satoshi, Sakura Nobuo, Hata Ikue, Shigematsu Yosuke, Kobayashi Masao
MOLECULAR GENETICS AND METABOLISM   119(4) 322-328   Dec 2016   [Refereed]
Okada S, Puel A, Casanova JL, Kobayashi M
Clinical & translational immunology   5(12) e114   Dec 2016   [Refereed]
Narumi H, Hasegawa S, Waki K, Fukuda K, Ohnishi Y, Ichimura T, Fujimoto Y, Katsura S, Kawano H, Ikeda E, Okada S, Ohga S
Journal of pediatric endocrinology & metabolism : JPEM   29(11) 1313-1317   Nov 2016   [Refereed]
Ma CS, Wong N, Rao G, Nguyen A, Avery DT, Payne K, Torpy J, O'Young P, Deenick E, Bustamante J, Puel A, Okada S, Kobayashi M, Martinez-Barricarte R, Elliott M, Sebnem Kilic S, El Baghdadi J, Minegishi Y, Bousfiha A, Robertson N, Hambleton S, Arkwright PD, French M, Blincoe AK, Hsu P, Campbell DE, Stormon MO, Wong M, Adelstein S, Fulcher DA, Cook MC, Stepensky P, Boztug K, Beier R, Ikincioğullari A, Ziegler JB, Gray P, Picard C, Boisson-Dupuis S, Phan TG, Grimbacher B, Warnatz K, Holland SM, Uzel G, Casanova JL, Tangye SG
The Journal of experimental medicine   213(8) 1589-1608   Jul 2016   [Refereed]
Tsujita Y, Mitsui-Sekinaka K, Imai K, Yeh TW, Mitsuiki N, Asano T, Ohnishi H, Kato Z, Sekinaka Y, Zaha K, Kato T, Okano T, Takashima T, Kobayashi K, Kimura M, Kunitsu T, Maruo Y, Kanegane H, Takagi M, Yoshida K, Okuno Y, Muramatsu H, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Kojima S, Ogawa S, Ohara O, Okada S, Kobayashi M, Morio T, Nonoyama S
The Journal of allergy and clinical immunology   138(6) 1672-1680.e10   Jun 2016   [Refereed]
Hiyama TY, Utsunomiya AN, Matsumoto M, Fujikawa A, Lin CH, Hara K, Kagawa R, Okada S, Kobayashi M, Ishikawa M, Anzo M, Cho H, Takayasu S, Nigawara T, Daimon M, Sato T, Terui K, Ito E, Noda M
Brain pathology (Zurich, Switzerland)   27(3) 323-331   Jun 2016   [Refereed]
Hara K, Tajima G, Okada S, Tsumura M, Kagawa R, Shirao K, Ohno Y, Yasunaga S, Ohtsubo M, Hata I, Sakura N, Shigematsu Y, Takihara Y, Kobayashi M
Molecular genetics and metabolism   118(1) 9-14   May 2016   [Refereed]
Toubiana J, Okada S, Hiller J, Oleastro M, Lagos Gomez M, Aldave Becerra JC, Ouachée-Chardin M, Fouyssac F, Girisha KM, Etzioni A, Van Montfrans J, Camcioglu Y, Kerns LA, Belohradsky B, Blanche S, Bousfiha A, Rodriguez-Gallego C, Meyts I, Kisand K, Reichenbach J, Renner ED, Rosenzweig S, Grimbacher B, van de Veerdonk FL, Traidl-Hoffmann C, Picard C, Marodi L, Morio T, Kobayashi M, Lilic D, Milner JD, Holland S, Casanova JL, Puel A
Blood   127(25) 3154-3164   Apr 2016   [Refereed]
Kataoka S, Muramatsu H, Okuno Y, Hayashi Y, Mizoguchi Y, Tsumura M, Okada S, Kobayashi M, Sano C, Sato H, Oh-Iwa I, Ito M, Kojima D, Hama A, Takahashi Y, Kojima S
The Journal of allergy and clinical immunology   137(2) 619-622   Feb 2016   [Refereed]
Hayakawa S, Okada S, Tsumura M, Sakata S, Ueno Y, Imai K, Morio T, Ohara O, Chayama K, Kobayashi M
Journal of clinical immunology   36(1) 28-32   Jan 2016   [Refereed]
Mizoguchi Y, Karakawa S, Doi T, Shimomura M, Tomioka K, Sakata S, Furue A, Chijimatsu I, Okada S, Miki M, Kawaguchi H, Kobayashi M.
Haematologica   101 336-337   2016   [Refereed]
Ma Cindy S, Wong Natalie, Rao Geetha, Avery Danielle T, Warnatz Klaus, Kobayashi Masao, Holland Steven M, Okada Satoshi, Bustamante Jacinta, Boisson-Dupuis Stephanie, Casanova Jean-Laurent, Uzel Gulbu, Tangye Stuart G.
Journal of Clinical Immunology   36(3) 40-47   2016   [Refereed]
Ma CS, Wong N, Rao G, Avery DT, Torpy J, Hambridge T, Bustamante J, Okada S, Stoddard JL, Deenick EK, Pelham SJ, Payne K, Boisson-Dupuis S, Puel A, Kobayashi M, Arkwright PD, Kilic SS, El Baghdadi J, Nonoyama S, Minegishi Y, Mahdaviani SA, Mansouri D, Bousfiha A, Blincoe AK, French MA, Hsu P, Campbell DE, Stormon MO, Wong M, Adelstein S, Smart JM, Fulcher DA, Cook MC, Phan TG, Stepensky P, Boztug K, Kansu A, İkincioğullari A, Baumann U, Beier R, Roscioli T, Ziegler JB, Gray P, Picard C, Grimbacher B, Warnatz K, Holland SM, Casanova JL, Uzel G, Tangye SG
The Journal of allergy and clinical immunology   136(4) 993-1006e1   Oct 2015   [Refereed]
Kreins AY, Ciancanelli MJ, Okada S, Kong XF, Ramírez-Alejo N, Kilic SS, El Baghdadi J, Nonoyama S, Mahdaviani SA, Ailal F, Bousfiha A, Mansouri D, Nievas E, Ma CS, Rao G, Bernasconi A, Sun Kuehn H, Niemela J, Stoddard J, Deveau P, Cobat A, El Azbaoui S, Sabri A, Lim CK, Sundin M, Avery DT, Halwani R, Grant AV, Boisson B, Bogunovic D, Itan Y, Moncada-Velez M, Martinez-Barricarte R, Migaud M, Deswarte C, Alsina L, Kotlarz D, Klein C, Muller-Fleckenstein I, Fleckenstein B, Cormier-Daire V, Rose-John S, Picard C, Hammarstrom L, Puel A, Al-Muhsen S, Abel L, Chaussabel D, Rosenzweig SD, Minegishi Y, Tangye SG, Bustamante J, Casanova JL, Boisson-Dupuis S
The Journal of experimental medicine   212(10) 1641-1662   Sep 2015   [Refereed]
Okada S, Markle JG, Deenick EK, Mele F, Averbuch D, Lagos M, Alzahrani M, Al-Muhsen S, Halwani R, Ma CS, Wong N, Soudais C, Henderson LA, Marzouqa H, Shamma J, Gonzalez M, Martinez-Barricarte R, Okada C, Avery DT, Latorre D, Deswarte C, Jabot-Hanin F, Torrado E, Fountain J, Belkadi A, Itan Y, Boisson B, Migaud M, Arlehamn CS, Sette A, Breton S, McCluskey J, Rossjohn J, de Villartay JP, Moshous D, Hambleton S, Latour S, Arkwright PD, Picard C, Lantz O, Engelhard D, Kobayashi M, Abel L, Cooper AM, Notarangelo LD, Boisson-Dupuis S, Puel A, Sallusto F, Bustamante J, Tangye SG, Casanova JL
Science (New York, N.Y.)   349(6248) 606-613   Aug 2015   [Refereed]
Hirata O, Okada S, Tsumura M, Karakawa S, Matsumura I, Kimura Y, Maihara T, Yasunaga S, Takihara Y, Ohara O, Kobayashi M
Journal of clinical immunology   35(5) 512-516   Jul 2015   [Refereed]
Morikawa S, Komatsu N, Sakata S, Nakamura-Utsunomiya A, Okada S, Tajima T
Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology   24(3) 135-138   Jul 2015   [Refereed]
Dobbs K, Domínguez Conde C, Zhang SY, Parolini S, Audry M, Chou J, Haapaniemi E, Keles S, Bilic I, Okada S, Massaad MJ, Rounioja S, Alwahadneh AM, Serwas NK, Capuder K, Çiftçi E, Felgentreff K, Ohsumi TK, Pedergnana V, Boisson B, Haskoloğlu Ş, Ensari A, Schuster M, Moretta A, Itan Y, Patrizi O, Rozenberg F, Lebon P, Saarela J, Knip M, Petrovski S, Goldstein DB, Parrott RE, Savas B, Schambach A, Tabellini G, Bock C, Chatila TA, Comeau AM, Geha RS, Abel L, Buckley RH, İkincioğulları A, Al-Herz W, Helminen M, Doğu F, Casanova JL, Boztuğ K, Notarangelo LD
The New England journal of medicine   372(25) 2409-2422   Jun 2015   [Refereed]
Ciancanelli MJ, Huang SX, Luthra P, Garner H, Itan Y, Volpi S, Lafaille FG, Trouillet C, Schmolke M, Albrecht RA, Israelsson E, Lim HK, Casadio M, Hermesh T, Lorenzo L, Leung LW, Pedergnana V, Boisson B, Okada S, Picard C, Ringuier B, Troussier F, Chaussabel D, Abel L, Pellier I, Notarangelo LD, García-Sastre A, Basler CF, Geissmann F, Zhang SY, Snoeck HW, Casanova JL
Science (New York, N.Y.)   348(6233) 448-453   Apr 2015   [Refereed]
Zhang X, Bogunovic D, Payelle-Brogard B, Francois-Newton V, Speer SD, Yuan C, Volpi S, Li Z, Sanal O, Mansouri D, Tezcan I, Rice GI, Chen C, Mansouri N, Mahdaviani SA, Itan Y, Boisson B, Okada S, Zeng L, Wang X, Jiang H, Liu W, Han T, Liu D, Ma T, Wang B, Liu M, Liu JY, Wang QK, Yalnizoglu D, Radoshevich L, Uzé G, Gros P, Rozenberg F, Zhang SY, Jouanguy E, Bustamante J, García-Sastre A, Abel L, Lebon P, Notarangelo LD, Crow YJ, Boisson-Dupuis S, Casanova JL, Pellegrini S
Nature   517(7532) 89-93   Jan 2015   [Refereed]
Nishimura Shiho, Tsumura Miyuki, Hirata Osamu, Kagawa Reiko, Mizoguchi Yoko, Okada Satoshi, Kobayashi Masao
Blood   126(23)    2015   [Refereed]
Markle Janet, Okada Satoshi, Deenick Elissa, Mele Federico, Averbuch Dina, Lagos Macarena, Gonzalez Marcela, Alzahrani Mohammed, Soudais Claire, Henderson Lauren, Deswarte Caroline, Jabot-Hanin Fabienne, Martinez-Barricarte Ruben, Itan Yuval, Boisson Bertrand, Cooper Andrea, Picard Capucine, Abel Laurent, Notarangelo Luigi, Boisson-Dupuis Stephanie, Puel Anne, Sallusto Federica, Bustamante Jacinta, Tangye Stuart, Casanova Jean-Laurent
Journal of Clinical Immunology   35 S13-S14   2015   [Refereed]
Okada Satoshi, Markle Janet, Kobayashi Masao, Bustamante Jacinta, Casanova Jean-Laurent
Blood   126(23)    2015   [Refereed]

Misc

 
野間 康輔, 土居 岳彦, 古森 遼太, 江口 勇太, 小野 大地, 松村 梨紗, 望月 慎史, 岡田 賢, 小林 正夫
日本小児科学会雑誌   122(7) 1213‐1219-1219   Jul 2018
Okada S
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology   40(2) 109‐117(J‐STAGE)-117   Apr 2017   [Refereed]
HARA Keiichi, HARA Keiichi, TAJIMA Go, OKADA Satoshi, SAKURA Nobuo
Advances in Modern Medicine, 2017   205‐209   2017

Conference Activities & Talks

 
反復する風邪、重症インフルエンザ感染症… 免疫不全症ではないですか?
岡田 賢
日本小児科学会雑誌   Feb 2019   
ELANE変異アレル破壊による遺伝子治療の検討
岡田 賢, 今中 雄介, 津村 弥来, 落合 博, 中田 慎一郎, 小原 收, 山本 卓, 小林 正夫
日本小児科学会雑誌   Feb 2019   
全国施行が実現したCPT2欠損症マススクリーニングの現状報告
但馬 剛, 原 圭一, 香川 礼子, 宇都宮 朱里, 津村 弥来, 岡田 賢, 湯浅 光織, 畑 郁江, 重松 陽介, 山口 清次
日本小児科学会雑誌   Feb 2019   
標識脂肪酸負荷末梢血単核球中のアシルカルニチン比による脂肪酸代謝異常症の診断
湯浅 光織, 畑 郁江, 杉原 啓一, 磯崎 由宇子, 重松 陽介, 大嶋 勇成, 津村 弥来, 香川 礼子, 岡田 賢, 原 圭一, 但馬 剛
日本小児科学会雑誌   Feb 2019   
重症先天性好中球減少症16例に対して有効であった骨髄移植
西村 志帆, 溝口 洋子, 古江 綾, 冨岡 啓太, 坂田 園子, 下村 麻衣子, 谷口 真紀, 森下 祐介, 加藤 豊, 松村 梨紗, 唐川 修平, 三木 瑞香, 土居 岳彦, 望月 慎史, 岡田 賢, 川口 浩史, 小林 正夫
日本小児科学会雑誌   Feb 2019   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2008 - 2009    Investigator(s): Satoshi OKADA
We tried to generate Severe Congenital Neutropenia (SCN) model mouse. We produced wild-type (WT), P110L, R101Q and C194X ELA2 by PCR-based mutagenesis and introduced them into retrovirus Tet-on gene expression vector. We performed gene expression ...