論文

査読有り 最終著者 国際誌
2020年10月14日

Clinical Significance of Serum Soluble TNF Receptor I/II Ratio for the Differential Diagnosis of Tumor Necrosis Factor Receptor-Associated Periodic Syndrome From Other Autoinflammatory Diseases

Frontiers in Immunology
  • Junko Yasumura
  • ,
  • Masaki Shimizu
  • ,
  • Tomoko Toma
  • ,
  • Masato Yashiro
  • ,
  • Akihiro Yachie
  • ,
  • Satoshi Okada

11
開始ページ
576152
終了ページ
576152
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3389/fimmu.2020.576152
出版者・発行元
Frontiers Media {SA}

Objectives: Genetic analysis of TNFRSF1A can confirm the diagnosis of tumor necrosis factor receptor-associated periodic syndrome (TRAPS), but interpretation of the pathogenesis of variants of unknown significance is sometimes required. The aim of this study was to evaluate the clinical significance of serum soluble tumor necrosis factor receptor type I (sTNFR-I)/II ratio to differentiate TRAPS from other autoinflammatory diseases. Methods: Serum sTNFR-I and sTNFR-II levels were measured using an enzyme-linked immunosorbent assay in patients with TRAPS (n = 5), familial Mediterranean fever (FMF) (n = 14), systemic juvenile idiopathic arthritis (s-JIA) (n = 90), and Kawasaki disease (KD) (n = 37) in the active and inactive phase, along with healthy controls (HCs) (n = 18). Results: In the active phase, the serum sTNFR-I/II ratio in patients with s-JIA, KD, and FMF was significantly elevated compared with that in HCs, whereas it was not elevated in patients with TRAPS. In the inactive phase, the serum sTNFR-I/II ratio in patients with s-JIA and FMF was significantly higher compared with that in HCs, and the ratio was lower in TRAPS patients than in patients with s-JIA and FMF. Conclusions: Low serum sTNFR-I/II ratio in the active and inactive phase might be useful for the differential diagnosis of TRAPS and other autoinflammatory diseases.

リンク情報
DOI
https://doi.org/10.3389/fimmu.2020.576152
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33162992
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591697
ID情報
  • DOI : 10.3389/fimmu.2020.576152
  • ISSN : 1664-3224
  • ORCIDのPut Code : 82513954
  • PubMed ID : 33162992
  • PubMed Central 記事ID : PMC7591697

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