2015年10月
Cold exposure and/or fasting modulate the relationship between sleep and body temperature rhythms in mice
PHYSIOLOGY & BEHAVIOR
- ,
- ,
- ,
- 巻
- 149
- 号
- 開始ページ
- 69
- 終了ページ
- 75
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.physbeh.2015.05.024
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
We assessed the relationship between core temperature (T-c) and sleep rhythms in mice, and examined the effects of ambient temperature and fasting. T-c, electroencephalograms (EEG), electromyograms (EMG), and spontaneous activity in male ICR mice (n = 9) were measured by telemetry for 3 days under a 12:12 h dark-light cycle. Mice were fed or fasted at an ambient temperature (T-a) of 27 degrees C or 20 degrees C for the final 30 h of the experiment. The vigilance state was categorized into a wake state, rapid-eye movement (REM) sleep, and non-REM (NREM) sleep, and the total sleep time (TST) was assessed. Relationships between T-c and TST, NREM periods, and REM sleep were estimated using Pearson's correlation coefficient. During cold exposure, T-c decreased during the dark and light phases, and TST and the periods of NREM and REM sleep decreased during the dark phase. Throughout the fasting period, T-c also decreased during the dark and light phases. Furthermore, the decrease in T-c was augmented when fasting and cold were combined. TST and NREM sleep periods decreased in the light and dark phases, respectively, whereas REM sleep periods decreased in both phases. Negative linear correlations (r = -0.884 to -0.987) were observed between T-c and TST, NREM sleep periods, and REM sleep periods, except for T-c and REM sleep periods where fasting and cold conditions were combined. The correlations between sleep and T-c rhythms were well maintained during cold exposure and fasting. However, when cold and fasting were combined, REM sleep and T-c rhythms were desynchronized. (C) 2015 Elsevier Inc. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.physbeh.2015.05.024
- ISSN : 0031-9384
- PubMed ID : 26025785
- Web of Science ID : WOS:000359026400011