2004年10月
Effects of static load on the weight and protein content in the leg muscles of the mouse: a simulation of prolonged standing in the workplace
INDUSTRIAL HEALTH
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- 巻
- 42
- 号
- 4
- 開始ページ
- 401
- 終了ページ
- 407
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2486/indhealth.42.401
- 出版者・発行元
- NATL INST INDUSTRIAL HEALTH
To simulate the effects of prolonged standing in the workplace on the leg muscles, we subjected mice to centrifugation for 6 wk. The absolute wet weight of leg muscles and internal organs of mice were measured after exposure to 3G by centrifugation for 6 wk and at 2 wk after removal of centrifugation. The weight of the soleus muscle (antigravity muscle) significantly increased after 6-wk exposure to centrifugation, but it decreased to its control weight 2 wk after removal of centrifugation. In contrast, the wet weights of the anterior tibial muscle, liver, and kidneys of mice centrifuged for 6 wk were significantly lower than those of the control mice; they had returned to control levels 2 wk after removal of centrifugation. It was therefore suggested that prolonged standing enlarged the leg muscles but its effect did not last for a long period of time after stopping prolonged standing. Western blot analysis of proteins extracted from the soleus muscle showed that vinculin and a-actinin in the centrifuged mice increased slightly, but there were no differences in the heat shock protein 70 (HSP70) and desmin levels between the centrifuged mice and control mice. No difference in HSP 70 suggested that muscle damage did not exist after 6 wk centrifugation.
- リンク情報
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- DOI
- https://doi.org/10.2486/indhealth.42.401
- CiNii Articles
- http://ci.nii.ac.jp/naid/40006660833
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/15540622
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000224765400002&DestApp=WOS_CPL
- ID情報
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- DOI : 10.2486/indhealth.42.401
- ISSN : 0019-8366
- CiNii Articles ID : 40006660833
- PubMed ID : 15540622
- Web of Science ID : WOS:000224765400002