MISC

2013年

Molecular characterization and tissue distribution of feline retinol-binding protein 4

Journal of Veterinary Medical Science
  • Noriyasu Sasaki
  • ,
  • Miwa Ishibashi
  • ,
  • Satoshi Soeta

75
10
開始ページ
1383
終了ページ
1387
記述言語
英語
掲載種別
速報,短報,研究ノート等(学術雑誌)
DOI
10.1292/jvms.13-0131

Retinol-binding protein 4 (RBP4) is a specific transporter of retinol and was recently identified as an adipokine potentially involved in type 2 diabetes in humans and rodents. However, the function and structure of feline RBP4 have not been reported. In this study, we describe the molecular cloning and expression analysis of feline RBP4. The complete feline RBP4 cDNA encodes a precursor protein comprising an 18 amino acid signal peptide and a 183 amino acid mature protein. Feline RBP4 was mapped to chromosome D2. Mature feline RBP4 is 83-94% homologous to the RBPs of humans, cows and rodents. RT-PCR analysis revealed feline RBP4 expression in liver and adipose tissues. © 2013 The Japanese Society of Veterinary Science.

リンク情報
DOI
https://doi.org/10.1292/jvms.13-0131
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23719693
ID情報
  • DOI : 10.1292/jvms.13-0131
  • ISSN : 0916-7250
  • ISSN : 1347-7439
  • PubMed ID : 23719693
  • SCOPUS ID : 84886852013

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