論文

査読有り
2015年10月

A Comparison of the Process of Remodeling of Hydroxyapatite/Poly-D/L-Lactide and Beta-Tricalcium Phosphate in a Loading Site.

Biomed Res Int
  • Hiroyuki Akagi
  • ,
  • Hiroki Ochi
  • ,
  • Satoshi Soeta
  • ,
  • Nobuo Kanno
  • ,
  • Megumi Yoshihara
  • ,
  • Kenshi Okazaki
  • ,
  • Takuya Yogo
  • ,
  • Yasuji Harada
  • ,
  • Hajime Amasaki
  • ,
  • Yasushi Hara

2015
開始ページ
730105
終了ページ
730105
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1155/2015/730105

Currently, the most commonly used bioresorbable scaffold is made of beta-tricalcium phosphate (β-TCP); it is hoped that scaffolds made of a mixture of hydroxyapatite (HA) and poly-D/L-lactide (PDLLA) will be able to act as novel bioresorbable scaffolds. The aim of this study was to evaluate the utility of a HA/PDLLA scaffold compared to β-TCP, at a loading site. Dogs underwent surgery to replace a section of tibial bone with a bioresorbable scaffold. After the follow-up period, the scaffold was subjected to histological analysis. The HA/PDLLA scaffold showed similar bone formation and superior cell and tissue infiltration compared to the β-TCP scaffold, as seen after Villanueva Goldner staining. Moreover, silver staining and immunohistochemistry for Von Willebrand factor and cathepsin K demonstrated better cell infiltration in the HA/PDLLA scaffold. The fibrous tissue and cells that had infiltrated into the HA/PDLLA scaffold tested positive for collagen type I and RUNX2, respectively, indicating that the tissue and cells that had infiltrated into the HA/PDLLA scaffold had the potential to differentiate into bone. The HA/PDLLA scaffold is therefore likely to find clinical applica

リンク情報
DOI
https://doi.org/10.1155/2015/730105
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26504825
ID情報
  • DOI : 10.1155/2015/730105
  • ISSN : 2314-6141
  • PubMed ID : 26504825

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