論文

2021年1月14日

Long-term administration of prednisolone: Effects on the myocardial tissue of healthy beagle dogs.

The Journal of veterinary medical science
  • Sachiyo Tanaka
  • ,
  • Hitomi Shibuya
  • ,
  • Shuji Suzuki
  • ,
  • Nobuo Kanno
  • ,
  • Yasuji Harada
  • ,
  • Asaka Sato
  • ,
  • Satoshi Soeta
  • ,
  • Yasushi Hara

83
1
開始ページ
84
終了ページ
93
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1292/jvms.20-0401

This study aimed to assess the structural and functional effects of long-term hyperglucocorticoidemia on canine myocardium and compare these parameters with histopathological changes. Twelve healthy male beagle dogs were enrolled and assigned to the high-dose prednisolone (P; n=6) and control (C; n=6) groups. The P group was treated with 2 mg/kg of prednisolone BID for 84 days. Clinical parameters were measured using echocardiography and non-invasive systolic blood pressure (SBP) measured before the initiation of synthetic corticosteroids and at 7, 28, 56, and 84 days after the start of medication. For histological evaluation, cardiovascular tissue was harvested from dogs in groups P (at the end of the medication period) and C (scheduled to be euthanized for unrelated reasons). In the P group, clinical changes including thickening of the left ventricular free wall (LVFW) and interventricular septum (IVS), decreased left ventricular (LV) diastolic function, and increased SBP were observed after the start of medication. During histological evaluation, fibrosis was observed in the LVFW and IVS in the P group. Furthermore, decreased glucocorticoid receptor (GCR) levels were observed in the LVFW, right ventricular free wall (RVFW), and IVS and increased mineralocorticoid receptor (MCR) levels were observed in the LVFW and RVFW in the P group compared with those in the C group. In conclusion, fibrosis may cause LV structural and functional abnormalities in dogs with hyperadrenocorticism. Furthermore, GCR downregulation and upregulated MCR might influence the myocardial fibrosis.

リンク情報
DOI
https://doi.org/10.1292/jvms.20-0401
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33268642
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870400
ID情報
  • DOI : 10.1292/jvms.20-0401
  • PubMed ID : 33268642
  • PubMed Central 記事ID : PMC7870400

エクスポート
BibTeX RIS