2018年2月
Estimation of physiological sources of nonlinearity in blood oxygenation level-dependent contrast signals
Magnetic Resonance Imaging
- ,
- ,
- 巻
- 46
- 号
- 開始ページ
- 121
- 終了ページ
- 129
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.mri.2017.10.017
- 出版者・発行元
- Elsevier Inc.
Blood oxygenation level-dependent (BOLD) contrast appears through a variation in the transverse relaxation rate of magnetic resonance signals induced by neurovascular coupling and is known to have nonlinear characteristics along echo time (TE) due to the intra-vasculature. However, the physiological causes of this nonlinearity are unclear. We attempted to estimate the physiological information related to the nonlinearity of BOLD signals by using a two-compartment model. For this purpose, we used a multi-echo gradient-echo echo-planar imaging sequence and developed a computational method to estimate the physiological information from the TE-dependent BOLD signals. The results showed that the average chemical exchange time in the intra-vasculature varied during stimulation, which might be the essential source of the nonlinearity.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.mri.2017.10.017
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/29122668
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000419426000016&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85035799151&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85035799151&origin=inward
- ID情報
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- DOI : 10.1016/j.mri.2017.10.017
- ISSN : 0730-725X
- eISSN : 1873-5894
- PubMed ID : 29122668
- SCOPUS ID : 85035799151
- Web of Science ID : WOS:000419426000016