2001年9月
UDP-sugar transporter implicated in glycosylation and processing of Notch
NATURE CELL BIOLOGY
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- 巻
- 3
- 号
- 9
- 開始ページ
- 816
- 終了ページ
- 822
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- MACMILLAN PUBLISHERS LTD
Glycosylation modifies protein activities in various biological processes. Here, we report the functions of a novel UDP-sugar transporter (UST74C, an alternative name for Fringe connection (Frc)) localized to the Golgi apparatus in cellular signalling of Drosophila. Mutants in the frc gene exhibit phenotypes resembling wingless and Notch mutants. Both Fringe-dependent and Fringe-independent Notch pathways are affected, and both glycosylation and proteolytic maturation of Notch are defective in mutant larvae. The results suggest that changes in nucleotide-sugar levels can differently affect Wingless and two distinct aspects of Notch signalling.
- リンク情報
- ID情報
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- ISSN : 1465-7392
- Web of Science ID : WOS:000170979600015