2004年9月
Wnt/beta-catenin and estrogen signaling converge in vivo
JOURNAL OF BIOLOGICAL CHEMISTRY
- 巻
- 279
- 号
- 39
- 開始ページ
- 40255
- 終了ページ
- 40258
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1074/jbc.C400331200
- 出版者・発行元
- AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Wnt and estrogen signaling represent important regulatory pathways, each controlling a wide range of biological processes. While an increasing number of observations suggest potential convergence between these pathways, no direct evidence of their functional interaction has been reported. Using human colon and breast cancer cells, we found that estrogen receptor (ER) alpha- and beta-catenin precipitated within the same immunocomplexes, reciprocally enhanced the transactivation of cognate reporter genes, and were reciprocally recruited to cognate response elements in the promoters of endogenous target genes. Using transgenic Drosophila that ectopically expressed human ERalpha alone or together with metabolically stable beta-catenin/Armadillo mutants, we demonstrated genetic interaction between these signal transducers in vivo. Thus, we present here the first direct evidence of cross-talk between Wnt and estrogen signaling pathways via functional interaction between beta-catenin and ERalpha.
- リンク情報
- ID情報
-
- DOI : 10.1074/jbc.C400331200
- ISSN : 0021-9258
- PubMed ID : 15304487
- Web of Science ID : WOS:000223916800003