2020年5月28日
Arylation of indoles using cyclohexanones dually-catalyzed by niobic acid and palladium-on-carbons
Organic and Biomolecular Chemistry
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- ,
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- 巻
- 18
- 号
- 20
- 開始ページ
- 3898
- 終了ページ
- 3902
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/d0ob00702a
© The Royal Society of Chemistry 2020. 3-Arylindoles were easily constructed from indoles and cyclohexanone derivatives using a combination of catalytic niobic acid-on-carbon (Nb2O5/C) and palladium-on-carbon (Pd/C) under heating conditions without any oxidants. The Lewis acidic Nb2O5/C promoted the nucleophilic addition of indoles to the cyclohexanones, and the subsequent dehydration and Pd/C-catalyzed dehydrogenation produced the 3-arylindoles. The additive 2,3-dimethyl-1,3-butadiene worked as a hydrogen acceptor to facilitate the dehydrogenation step.
- リンク情報
- ID情報
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- DOI : 10.1039/d0ob00702a
- ISSN : 1477-0520
- PubMed ID : 32400844
- SCOPUS ID : 85085537608