2018年12月
Streptococcus pyogenes-purpura fulminans as an invasive form of group A streptococcal infection
Annals of Clinical Microbiology and Antimicrobials
- 巻
- 17
- 号
- 1
- 開始ページ
- 31
- 終了ページ
- 31
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1186/s12941-018-0282-9
- 出版者・発行元
- Springer Science and Business Media LLC
BACKGROUND: Streptococcus pyogenes is an uncommon pathogen of purpura fulminans, and the pathogenesis of S. pyogenes-purpura fulminans remains unclear because of paucity of cases. We reported a pediatric case of S. pyogenes-purpura fulminans with literature review of the disease. CASE PRESENTATION: A 3-year-old boy showed limping, lethargy and acral gangrene within 24 h. A diagnosis of S. pyogenes-purpura fulminans was made for bacterial isolation from throat and peripheral blood. Intensive therapy led to a survival with amputation of the left distal metatarsal bone, and normal development. The isolated M12 carried no mutation of csrS/R or rgg. Thrombophilia or immunodeficiency was excluded. DISCUSSION: Twelve-reported cases (9 pediatric and 3 elderly) of S. pyogenes-purpura fulminans started with shock and coagulopathy. Five patients age < 8 years had no underlying disease and survived. One youngest and two immunocompromised patients died. CONCLUSION: Streptococcus pyogenes-acute infectious purpura fulminans is a distinctive rare form of aggressive GAS infections.
- リンク情報
-
- DOI
- https://doi.org/10.1186/s12941-018-0282-9
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/29986727
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036671
- URL
- http://link.springer.com/content/pdf/10.1186/s12941-018-0282-9.pdf
- URL
- http://link.springer.com/article/10.1186/s12941-018-0282-9/fulltext.html
- ID情報
-
- DOI : 10.1186/s12941-018-0282-9
- eISSN : 1476-0711
- PubMed ID : 29986727
- PubMed Central 記事ID : PMC6036671