SAKAI Ryuichi

J-GLOBAL         Last updated: May 11, 2019 at 17:09
 
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Name
SAKAI Ryuichi
Affiliation
Hokkaido University
Section
Faculty of Fisheries Sciences
Job title
Professor
Degree
Ph.D.
Research funding number
20265721

Research Areas

 
 

Education

 
 
 - 
1992
Graduate School, Division of Chemistry, University of Illinois at Urban
 
 
 - 
1983
Faculty of Science, University of the Ryukyus
 

Published Papers

 
Sakai R, Tanano K, Ono T, Kitano M, Iida Y, Nakano K, Jimbo M
Marine drugs   17(4)    Apr 2019   [Refereed]
Watari H, Nakajima H, Atsuumi W, Nakamura T, Nanya T, Ise Y, Sakai R
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP   221 82-88   Apr 2019   [Refereed]
Shiozaki H, Miyahara M, Otsuka K, Miyako K, Honda A, Takasaki Y, Takamizawa S, Tukada H, Ishikawa Y, Sakai R, Oikawa M
Organic letters   20(11) 3403-3407   Jun 2018   [Refereed]
Matsumura K, Taniguchi T, Reimer JD, Noguchi S, Fujita MJ, Sakai R
Organic letters   20(10) 3039-3043   May 2018   [Refereed]
Motohashi S, Jimbo M, Naito T, Suzuki T, Sakai R, Kamiya H
Marine drugs   15(6)    Jun 2017   [Refereed]
Kita A, Jimbo M, Sakai R, Morimoto Y, Takeuchi R, Tanaka H, Takahashi T, Miki K
Glycobiology      May 2017   [Refereed]
Tadokoro Y, Nishikawa T, Ichimori T, Matsunaga S, Fujita MJ, Sakai R
ACS omega   2(3) 1074-1080   Mar 2017   [Refereed]
Hajime Uchimasu, Ken Matsumura, Masashi Tsuda, Keiko Kumagai, Mai Akakabe, Masaki J. Fujita, Ryuichi Sakai
Tetrahedron   72 7185-7193   Nov 2016
© 2016 Elsevier LtdNovel guanidine alkaloids dopargimine (1) and mellpaladines A–C (2–4) were isolated from a Palauan Didemnidae tunicate. The structures of 1–4 were elucidated on the basis of spectral data along with chemical reactions. A putativ...
Fukushima K, Ishikawa Y, Sakai R, Oikawa M
Bioorganic & medicinal chemistry letters   26(21) 5164-5167   Nov 2016   [Refereed]
Chiba M, Ishikawa Y, Sakai R, Oikawa M
ACS combinatorial science   18(7) 399-404   Jul 2016   [Refereed]
Kita A, Jimbo M, Sakai R, Morimoto Y, Miki K
Glycobiology   25(9) 1016-1023   Sep 2015   [Refereed]
Chiba M, Fujimoto C, Sakai R, Oikawa M
Bioorganic & medicinal chemistry letters   25(9) 1869-1871   May 2015   [Refereed]
Fujita MJ, Sakai R
Marine drugs   12(9) 4799-4809   Sep 2014   [Refereed]
Matsunaga S, Kishi R, Otsuka K, Fujita MJ, Oikawa M, Sakai R
Organic letters   16(11) 3090-3093   Jun 2014   [Refereed]
Copits BA, Vernon CG, Sakai R, Swanson GT
The Journal of physiology   592(10) 2079-2096   Apr 2014   [Refereed]
Sakai R, Swanson GT
Natural product reports   31(2) 273-309   Jan 2014   [Refereed]
Sasaki S, Suzuki H, Ouchi H, Asakawa T, Inai M, Sakai R, Shimamoto K, Hamashima Y, Kan T
Organic letters   16(2) 564-567   Jan 2014   [Refereed]
Fujita MJ, Sakai R
Bioscience, biotechnology, and biochemistry   77(12) 2467-2472   Dec 2013   [Refereed]
Fujita MJ, Nakano K, Sakai R
Molecules (Basel, Switzerland)   18(4) 3917-3926   Apr 2013   [Refereed]
Juknaitė L, Sugamata Y, Tokiwa K, Ishikawa Y, Takamizawa S, Eng A, Sakai R, Pickering DS, Frydenvang K, Swanson GT, Kastrup JS, Oikawa M
Journal of medicinal chemistry   56(6) 2283-2293   Mar 2013   [Refereed]
Ueda T, Nakamura Y, Smith C, Copits BA, Inoue A, Ojima T, Matsunaga S, Swanson GT, Sakai R
Glycobiology   23(4) 412-425   Dec 2012   [Refereed]
Freymann DM, Nakamura Y, Focia PJ, Sakai R, Swanson GT
Acta crystallographica. Section D, Biological crystallography   68(9) 1163-1174   Sep 2012   [Refereed]
Novel tetrameric galectin from a marine sponge potentiates mammalian glutamate receptor function
Ueda Takuya, Nakamura Yuka, Focia Pamela J., Smith Caleb, Inoue Akira, Ojima Takao, Matsunaga Satoko, Freymann Douglas M., Sakai Ryuichi, Swanson Geoffrey T.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   244    Aug 2012   [Refereed]
Unno M, Shinohara M, Takayama K, Tanaka H, Teruya K, Doh-ura K, Sakai R, Sasaki M, Ikeda-Saito M
Journal of molecular biology   413(3) 667-683   Oct 2011   [Refereed]
Matsunaga S, Jimbo M, Gill MB, Wyhe LL, Murata M, Nonomura K, Swanson GT, Sakai R
Chembiochem : a European journal of chemical biology   12(14) 2191-2200   Sep 2011   [Refereed]
Qiu CS, Lash-Van Wyhe L, Sasaki M, Sakai R, Swanson GT, Gereau RW 4th
Pain   152(5) 1052-1060   May 2011   [Refereed]
Sakurada T, Gill MB, Frausto S, Copits B, Noguchi K, Shimamoto K, Swanson GT, Sakai R
Journal of medicinal chemistry   53(16) 6089-6099   Aug 2010   [Refereed]
Oikawa M, Ikoma M, Sasaki M, Gill MB, Swanson GT, Shimamoto K, Sakai R
Bioorganic & medicinal chemistry   18(11) 3795-3804   Jun 2010   [Refereed]
Lash-Van Wyhe LL, Postila PA, Tsubone K, Sasaki M, Pentikäinen OT, Sakai R, Swanson GT
Neuropharmacology   58(3) 640-649   Mar 2010   [Refereed]
Oikawa M, Ikoma M, Sasaki M, Gill MB, Swanson GT, Shimamoto K, Sakai R
European journal of organic chemistry   2009(32) 5531-5548   Nov 2009   [Refereed]
Frydenvang K, Lash LL, Naur P, Postila PA, Pickering DS, Smith CM, Gajhede M, Sasaki M, Sakai R, Pentikaïnen OT, Swanson GT, Kastrup JS
The Journal of biological chemistry   284(21) 14219-14229   May 2009   [Refereed]
Swanson GT, Sakai R
Progress in molecular and subcellular biology   46 123-157   2009   [Refereed]
Ikoma M, Oikawa M, Gill MB, Swanson GT, Sakai R, Shimamoto K, Sasaki M
European journal of organic chemistry   2008(31) 5215-5220   Nov 2008   [Refereed]
Sakai R, Yoshida K, Kimura A, Koike K, Jimbo M, Koike K, Kobiyama A, Kamiya H
Chembiochem : a European journal of chemical biology   9(4) 543-551   Mar 2008   [Refereed]
Lash LL, Sanders JM, Akiyama N, Shoji M, Postila P, Pentikäinen OT, Sasaki M, Sakai R, Swanson GT
The Journal of pharmacology and experimental therapeutics   324(2) 484-496   Feb 2008   [Refereed]
Sasaki M, Tsubone K, Aoki K, Akiyama N, Shoji M, Oikawa M, Sakai R, Shimamoto K
The Journal of organic chemistry   73(1) 264-273   Jan 2008   [Refereed]
Matsunaga S, Sakai R, Jimbo M, Kamiya H
Chembiochem : a European journal of chemical biology   8(14) 1729-1735   Sep 2007   [Refereed]
Jimbo M, Usui R, Sakai R, Muramoto K, Kamiya H
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology   147(2) 164-171   Jun 2007   [Refereed]
Cheng JF, Lee JS, Sakai R, Jares-Erijman EA, Silva MV, Rinehart KL
Journal of natural products   70(3) 332-336   Mar 2007   [Refereed]
Sasaki M, Tsubone K, Shoji M, Oikawa M, Shimamoto K, Sakai R
Bioorganic & medicinal chemistry letters   16(22) 5784-5787   Nov 2006   [Refereed]
Sakai R, Kamiya H
The Journal of antibiotics   59(8) 507-511   Aug 2006   [Refereed]
Shoji M, Akiyama N, Tsubone K, Lash LL, Sanders JM, Swanson GT, Sakai R, Shimamoto K, Oikawa M, Sasaki M
The Journal of organic chemistry   71(14) 5208-5220   Jul 2006   [Refereed]
Sanders JM, Pentikäinen OT, Settimo L, Pentikäinen U, Shoji M, Sasaki M, Sakai R, Johnson MS, Swanson GT
Molecular pharmacology   69(6) 1849-1860   Jun 2006   [Refereed]
Sakai R, Nakamura T, Nishino T, Yamamoto M, Miyamura A, Miyamoto H, Ishiwata N, Komatsu N, Kamiya H, Tsuruzoe N
Bioorganic & medicinal chemistry   13 6388-6393   Dec 2005   [Refereed]
Sakai R, Minato S, Koike K, Koike K, Jimbo M, Kamiya H
Cell and tissue research   322 491-502   Dec 2005   [Refereed]
Sanders JM, Ito K, Settimo L, Pentikäinen OT, Shoji M, Sasaki M, Johnson MS, Sakai R, Swanson GT
The Journal of pharmacology and experimental therapeutics   314 1068-1078   Sep 2005   [Refereed]
Jimbo M, Koike K, Sakai R, Muramoto K, Kamiya H
Biochemical and biophysical research communications   330(1) 157-162   Apr 2005   [Refereed]
Koike K, Jimbo M, Sakai R, Kaeriyama M, Muramoto K, Ogata T, Maruyama T, Kamiya H
The Biological bulletin   207(2) 80-86   Oct 2004   [Refereed]
Shimamoto K, Sakai R, Takaoka K, Yumoto N, Nakajima T, Amara SG, Shigeri Y
Molecular pharmacology   65(4) 1008-1015   Apr 2004   [Refereed]
Sakai R, Suzuki K, Shimamoto K, Kamiya H
The Journal of organic chemistry   69(4) 1180-1185   Feb 2004   [Refereed]
Sakai R, Matsubara H, Shimamoto K, Jimbo M, Kamiya H, Namikoshi M
Journal of natural products   66(6) 784-787   Jun 2003   [Refereed]
Sakai R, Koike T, Sasaki M, Shimamoto K, Oiwa C, Yano A, Suzuki K, Tachibana K, Kamiya H
Organic letters   3(10) 1479-1482   May 2001   [Refereed]
Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbacea.
Sakai R, Swanson GT, Shimamoto K, Green T, Contractor A, Ghetti A, Tamura-Horikawa Y, Oiwa C, Kamiya H
The Journal of pharmacology and experimental therapeutics   296 650-658   Feb 2001   [Refereed]
Sato S, Sakai R, Kodama M
Bioorganic & medicinal chemistry letters   10(16) 1787-1789   Aug 2000   [Refereed]
Jimbo M, Yanohara T, Koike K, Koike K, Sakai R, Muramoto K, Kamiya H
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology   125 227-236   Feb 2000   [Refereed]
Yamaguchi M, Jimbo M, Sakai R, Muramoto K, Kamiya H
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology   119 593-597   Mar 1998   [Refereed]
Sakai R, Rinehart KL, Kishore V, Kundu B, Faircloth G, Gloer JB, Carney JR, Namikoshi M, Sun F, Hughes RG Jr, García Grávalos D, de Quesada TG, Wilson GR, Heid RM
Journal of medicinal chemistry   39(14) 2819-2834   Jul 1996   [Refereed]
Sakai R, Rinehart KL
Journal of natural products   58(5) 773-777   May 1995   [Refereed]
Molecular and crystal structures of ecteinascidins: potent antitumor compounds from the Caribbean tunicate Ecteinascidia turbinata.
Guan Y, Sakai R, Rinehart KL, Wang AH
Journal of biomolecular structure & dynamics   10 793-818   Apr 1993   [Refereed]
Rinehart KL, Holt TG, Fregeau NL, Keifer PA, Wilson GR, Perun TJ Jr, Sakai R, Thompson AG, Stroh JG, Shield LS
Journal of natural products   53(4) 771-792   Jul 1990   [Refereed]
Rinehart KL, Kishore V, Bible KC, Sakai R, Sullins DW, Li KM
Journal of natural products   51 624   May 1988   [Refereed]
Didemnins and tunichlorin: novel natural products from the marine tunicate Trididemnum solidum.
Rinehart KL, Kishore V, Bible KC, Sakai R, Sullins DW, Li KM
Journal of natural products   51 1-21   Jan 1988   [Refereed]

Misc

 
酒井隆一
天然薬物の開発と応用シンポジウム講演要旨集   22nd 1‐4   Oct 2018
酒井隆一
東和食品研究振興会奨励研究報告書   2017 1‐11   Dec 2018
内舛肇, ENG Andrew, EKINS Merrick, HOOPER John, SWANSON Geoofrey T., 酒井隆一
日本水産学会大会講演要旨集   2014 121   Mar 2014
SAKAI RYUICHI, SAKAI RYUICHI
トキシンシンポジウム予稿集   62nd 89   Jun 2015
飯田祐介, 中野宏治, 上田拓也, 北野雅也, 藤田雅紀, 酒井隆一
日本水産学会大会講演要旨集   2018 107   Mar 2018

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2007 - 2009    Investigator(s): Yasushi SHIGERI
Alanine-serine-cysteine transporters (ASCT1, 2) are neutral amino acids transporters. Their representative substrates are alanine, serine and cysteine. Since th ere is no specific inhibitors or substrates for ASCT1 and ASCT2, their physiological f...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2005 - 2007    Investigator(s): Ryuichi SAKAI
In the present study, we identified new polyamines from a Okinawan sponge Axinissa aculeate that modulate ligand binding to NMDA type glutamate receptors. These polyamines may also function as a factor involved in silica biomineralization in the s...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2003 - 2005    Investigator(s): Hisao KAMIYA
The D-galactose-binding lectin, Sll-2, in the octocoral was effectively purified by affinithy chromatography on D-galactosamine-HiTrap column using Tris-HCl buffer containing 0.5% L-ascorbic acid and 0.1% kojic acid to avoid melanization and insol...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2003 - 2004    Investigator(s): Ryuichi SAKAI
We have investigated the cellular localization of the marine sponge-derived excitatory amino acid dysiherbaine (DH), and found that DH-like immunoreactivity was densely located in the large (10 μm) globular cells. On the basis of 18S rDNA sequence...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2000 - 2003    Investigator(s): Shigeru SATO
Although many sophisticated analyzing methods for paralytic shellfish toxins (PSP toxins) have been developed, mouse bioassay is still applied as official method for monitoring of bivalve toxicity in various countries including Japan. Mouse bioass...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2000 - 2002    Investigator(s): Hisao KAMIYA
The cDNA cloning of SLL-2, a D-galactose-binding lectin of the octocoral Sinularia lochmodes, has revealed that SLL-2 had a sequence homology to those of "discoidin" group lectins. It is observed that the difference of 2 kD in the molecular weight...
Isolation and structure determination of Bioactive Marine natural products.