2018年6月1日
Studies on Aculeines: Synthetic Strategy to the Fully Protected Protoaculeine B, the N-Terminal Amino Acid of Aculeine B.
Organic letters
- 巻
- 20
- 号
- 11
- 開始ページ
- 3403
- 終了ページ
- 3407
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.orglett.8b01331
A synthetic strategy for accessing protoaculeine B (1), the N-terminal amino acid of the highly modified peptide toxin aculeine, was developed via the synthesis of the fully protected natural homologue of 1 with a 12-mer poly(propanediamine). The synthesis of mono(propanediamine) analog 2, as well as core amino acid 3, was demonstrated by this strategy. New amino acid 3 induced convulsions in mice; however, compound 2 showed no such activity.
- リンク情報
- ID情報
-
- DOI : 10.1021/acs.orglett.8b01331
- ISSN : 1523-7060
- PubMed ID : 29790756