2021年4月23日
Structure Revision of Protoaculeine B, a Post-translationally Modified N-Terminal Residue in the Peptide Toxin Aculeine B.
Journal of natural products
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- ,
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- 巻
- 84
- 号
- 4
- 開始ページ
- 1203
- 終了ページ
- 1209
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.jnatprod.0c01280
The structure of protoaculeine B, the N-terminal residue of the marine peptide toxin aculeine B, is revised to the cis-1,3-disubstituted tetrahydro-β-carboline framework. We prepared two truncated model compounds that lack a long-chain polyamine using the one-step Pictet-Spengler reaction of tryptophan and compared their NMR, mass spectra, and chemical reactivity with those of the natural protoaculeine B. The synthetic models reproduced the profiles of the natural product well, which confirmed the appropriateness of the structure revision.
- リンク情報
- ID情報
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- DOI : 10.1021/acs.jnatprod.0c01280
- PubMed ID : 33787261