論文

査読有り
2014年2月

Efficacy of zinc-carnosine chelate compound, Polaprezinc, enemas in patients with ulcerative colitis

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
  • Munenori Itagaki
  • ,
  • Masayuki Saruta
  • ,
  • Hiroki Saijo
  • ,
  • Jimi Mitobe
  • ,
  • Seiji Arihiro
  • ,
  • Mika Matsuoka
  • ,
  • Tomohiro Kato
  • ,
  • Masahiro Ikegami
  • ,
  • Hisao Tajiri

49
2
開始ページ
164
終了ページ
172
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3109/00365521.2013.863963
出版者・発行元
INFORMA HEALTHCARE

Objectives. Ulcerative colitis (UC) is a chronic, relapsing and remitting intestinal inflammatory disorder. Zinc is known to be efficacious for the repair of damaged tissue and has been shown to protect against gastric ulceration. This study focused on Polaprezinc (PZ), N-(3-aminopropionyl)-L-histidinato zinc, which accelerates ulcer healing through actions such as prostaglandin-independent cytoprotection and antioxidative activity. Methods. In this randomized, placebo-controlled, investigator-blinded trial, 28 patients with active UC at The Jikei University Hospital were randomly divided into two groups: one treated with a 150 mg PZ enema (n = 18) and the other not treated with a PZ enema (n = 10). All patients received usual induction therapy. Clinical symptoms, endoscopic findings and histological findings were evaluated at entry and one week later. Results. In the PZ group, modified Matts' endoscopic scores were significantly improved after treatment compared to baseline in the rectum (p = 0.004), sigmoid colon (p = 0.03) and descending colon (p = 0.04). In the non-PZ group, scores were not significantly improved in the rectum (p = 0.14) and descending colon (p = 0.34), but were improved in the sigmoid colon (p = 0.04). In the PZ group, the Mayo scores at baseline and at Day 8 were 9.1 +/- 1.6 and 5.8 +/- 2.7 (p = 0.00004), respectively, and in the placebo group, the scores were 8.9 +/- 1.7 and 7.4 +/- 2.1 (p = 0.009), respectively. Clinical response or remission was significantly better in the PZ group (71%) than in the placebo group (10%). Conclusions. A zinc-carnosine chelate compound, PZ, enema may become a useful new add-on treatment to accelerate mucosal healing in UC.

Web of Science ® 被引用回数 : 10

リンク情報
DOI
https://doi.org/10.3109/00365521.2013.863963
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24286534
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000329874800005&DestApp=WOS_CPL

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