竹島功高 (Kosuke Takeshima) - マイポータル

基本情報

所属: 東京大学医科学研究所ウイルス病態制御分野特任研究員

学位: 博士（医学）(2020年3月東京大学大学院)

研究者番号: 30882500
J-GLOBAL ID: 202001005676314057
researchmap会員ID: R000010707

論文

Identification of viral activators of the HSV-2 UL13 protein kinase.

Naoto Koyanagi, Kosuke Takeshima, Saori Shio, Yuhei Maruzuru, Akihisa Kato, Yasushi Kawaguchi

Journal of virology 99(10) e0116525 2025年10月23日
Herpes simplex virus 1 evades APOBEC1-mediated immunity via its uracil-DNA glycosylase in mice.

Akihisa Kato, Hayato Harima, Yuji Tsunekawa, Manabu Igarashi, Kouichi Kitamura, Kousho Wakae, Tomoaki Nishiyama, Satoru Morimoto, Toru Suzuki, Hiroko Kozuka-Hata …

Nature microbiology 10(7) 1758-1774 2025年7月
Impact of the changes in substrate specificity of herpes simplex virus 1 protein kinase Us3 on viral infection in vitro and in vivo.

Saori Shio, Akihisa Kato, Jurika Kawasaki, Kousuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Hayato Harima, Yasushi Kawaguchi

Journal of virology e0040025 2025年6月30日
Direct relationship between protein expression and progeny yield of herpes simplex virus 1

Moeka Nobe, Yuhei Maruzuru, Kosuke Takeshima, Fumio Maeda, Hideo Kusano, Raiki Yoshimura, Takara Nishiyama, Hyeongki Park, Yoshitaka Kozaki, Shingo Iwami …

mBio 2025年5月5日
Regulatory mimicry of cyclin-dependent kinases by a conserved herpesvirus protein kinase

Naoto Koyanagi, Kowit Hengphasatporn, Akihisa Kato, Moeka Nobe, Kosuke Takeshima, Yuhei Maruzuru, Katsumi Maenaka, Yasuteru Shigeta, Yasushi Kawaguchi

Proceedings of the National Academy of Sciences of the United States of America 122(16) e2500264122 2025年4月16日査読有り
Impact of the interaction between herpes simplex virus 1 ICP22 and FACT on viral gene expression and pathogenesis

Shaocong Liu, Yuhei Maruzuru, Kosuke Takeshima, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi

Journal of Virology 2024年7月17日
Identification of a novel neurovirulence factor encoded by the cryptic orphan gene UL31.6 of herpes simplex virus 1.

Akihisa Kato, Ryoji Iwasaki, Kousuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Tohru Natsume, Hideo Kusano, Shungo Adachi, Shuichi Kawano, Yasushi Kawaguchi

Journal of virology 98(7) e0074724 2024年5月31日
MYBBP1A is required for efficient replication and gene expression of herpes simplex virus 1.

Moeka Nobe, Yuhei Maruzuru, Kosuke Takeshima, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi

Microbiology and immunology 68(4) 148-154 2024年4月
Associations of HLA-C*01:02 and HLA-B*46:01 with regorafenib-induced erythema multiforme in Japanese patients with metastatic colorectal cancer.

Ken-Ichi Fujita, Natsumi Matsumoto, Remi Murase, Kosuke Takeshima, Hiroo Ishida, Yutaro Kubota

Clinical and translational science 16(10) 1741-1747 2023年10月
Evasion of APOBEC1-mediated Intrinsic Immunity by a Herpesvirus Uracil DNA Glycosylase Is a Determinant of Viral Encephalitis

Akihisa Kato, Hayato Harima, Yuji Tsunekawa, Manabu Igarashi, Kouichi Kitamura, Kousho Wakae, Hiroko Kozuka-Hata, Masaaki Oyama, Mizuki Watanabe, Kousuke Takeshima …

2023年6月23日
Establishment of a system to quantify wild-type herpes simplex virus-induced cell-cell fusion reveals a role of N-glycosylation of HSV-1 envelope glycoprotein B in cell-cell fusion.

Ayano Fukui, Yuhei Maruzuru, Kosuke Takeshima, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi

Microbiology and immunology 67(3) 114-119 2023年3月
Dual Impacts of a Glycan Shield on the Envelope Glycoprotein B of HSV-1: Evasion from Human Antibodies In Vivo and Neurovirulence

Ayano Fukui, Yuhei Maruzuru, Shiho Ohno, Moeka Nobe, Shuji Iwata, Kosuke Takeshima, Naoto Koyanagi, Akihisa Kato, Shinobu Kitazume, Yoshiki Yamaguchi …

2022年12月13日
Redundant and Specific Roles of A-Type Lamins and Lamin B Receptor in Herpes Simplex Virus 1 Infection.

Kosuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi

Journal of virology e0142922 2022年11月30日
Role of the Orphan Transporter SLC35E1 in the Nuclear Egress of Herpes Simplex Virus 1.

Fumio Maeda, Akihisa Kato, Kosuke Takeshima, Misato Shibazaki, Ryota Sato, Takuma Shibata, Kensuke Miyake, Hiroko Kozuka-Hata, Masaaki Oyama, Eigo Shimizu …

Journal of virology 96(10) e0030622 2022年4月27日
Role of the arginine cluster in the disordered domain of Herpes Simplex Virus 1 UL34 for the recruitment of ESCRT-III for viral primary envelopment.

Jun Arii, Kosuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Yoshitaka Nakayama, Akihisa Kato, Yasuko Mori, Yasushi Kawaguchi

Journal of virology JVI0170421 2021年11月3日
Prohibitin-1 Contributes to the Cell-to-Cell Transmission of Herpes Simplex Virus 1.

Mizuki Watanabe, Jun Arii, Kosuke Takeshima, Ayano Fukui, Masayuki Shimojima, Hiroko Kozuka-Hata, Masaaki Oyama, Takeharu Minamitani, Teruhito Yasui, Yuji Kubota …

Journal of virology 95(3) 2020年11月11日
Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics.

Akihisa Kato, Shungo Adachi, Shuichi Kawano, Kousuke Takeshima, Mizuki Watanabe, Shinobu Kitazume, Ryota Sato, Hideo Kusano, Naoto Koyanagi, Yuhei Maruzuru …

Nature communications 11(1) 4894-4894 2020年9月29日査読有り
Phosphoregulation of a Conserved Herpesvirus Tegument Protein by a Virally Encoded Protein Kinase in Viral Pathogenicity and Potential Linkage between Its Evolution and Viral Phylogeny.

Misato Shibazaki, Akihisa Kato, Kosuke Takeshima, Jumpei Ito, Mai Suganami, Naoto Koyanagi, Yuhei Maruzuru, Kei Sato, Yasushi Kawaguchi

Journal of virology 94(18) 2020年8月31日査読有り
Identification of the Capsid Binding Site in the Herpes Simplex Virus 1 Nuclear Egress Complex and Its Role in Viral Primary Envelopment and Replication.

Kosuke Takeshima, Jun Arii, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi

Journal of virology 93(21) 2019年11月1日査読有り
Roles of the Interhexamer Contact Site for Hexagonal Lattice Formation of the Herpes Simplex Virus 1 Nuclear Egress Complex in Viral Primary Envelopment and Replication.

Jun Arii, Kosuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi

Journal of virology 93(14) 2019年7月15日査読有り

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