Sei-ichiro Motegi

Last updated: Nov 12, 2019 at 21:06

Name	Sei-ichiro Motegi
Affiliation	Gunma University

Research Interests

Wound healing(59) , Systemic sclerosis(10) , MFG-E8(1) , Signal transduction(283) , Angiogenesis(111) , melanoma(17) , Skin immunity(1) , CD47-SHPS-1(1)

Research Areas

Clinical internal medicine / Dermatology /

Academic & Professional Experience

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Oct 2007

Jun 2011

visiting fellow, National Institutes of Health, National Cancer Institute, Dermatology Branch

Awards & Honors

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Apr 2019

The 63rd Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology (JCR 2019) Excellent Abstract Award

Jul 2018

JD Award (Most cited paper 2017 impact factor period), Journal of Dermatology

Dec 2017

2017 JSID Award

http://www.med.gunma-u.ac.jp/newsrelease/news/5213.html

Published Papers

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Six cases of perforating pilomatricoma: Anetodermic changes with expression of matrix metalloproteinases.

Watabe D, Mori S, Akasaka T, Motegi SI, Ishikawa O, Amano H

The Journal of dermatology Nov 2019 [Refereed]

Clinical features and poor prognostic factors of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis with rapid progressive interstitial lung disease.

Motegi SI, Sekiguchi A, Toki S, Kishi C, Endo Y, Yasuda M, Ikeuchi H, Sakairi T, Hara K, Yamaguchi K, Maeno T, Hiromura K, Ishikawa O

European journal of dermatology : EJD Oct 2019 [Refereed]

Response to the letter by Dr. Costa-Moreira, Dr. Peixoto, Dr. Ramalho, and Dr. Macedo regarding our manuscript: "Relationship between esophageal motility abnormalities and skin or lung involvements in patients with systemic sclerosis".

Kuribayashi S, Motegi SI, Hara K, Sekiguchi A, Hosaka H, Kusano M, Uraoka T

Journal of gastroenterology Sep 2019 [Refereed]

Nanoparticle Albumin-Bound Paclitaxel and/or Gemcitabine-Induced Scleroderma Accompanied by Acanthosis Nigricans-Like Skin Changes

Motegi S, Ishikawa M, Sekiguchi A, Ishikawa O.

Case Reports in Dermatology Sep 2019 [Refereed]

Unresectable local recurrence of dermatofibrosarcoma protuberans with fibrosarcomatous change treated with carbon-ion radiotherapy after neoadjuvant chemotherapy.

Kim J, Yasuda M, Suto M, Kishi C, Motegi SI, Okamoto M, Ishikawa O

The Journal of dermatology Aug 2019 [Refereed]

Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin.

Nakamura H, Sekiguchi A, Ogawa Y, Kawamura T, Akai R, Iwawaki T, Makiguchi T, Yokoo S, Ishikawa O, Motegi SI

Journal of dermatological science Jul 2019 [Refereed]

Immunological and Clinicopathological Significance of MFG-E8 Expression in Patients with Oral Squamous Cell Carcinoma.

Okamoto A, Sakakura K, Takahashi H, Motegi SI, Kaira K, Yokobori-Kuwabara Y, Ishikawa O, Chikamatsu K

Pathology oncology research : POR Jun 2019 [Refereed]

The Regulation of Skin Fibrosis in Systemic Sclerosis by Extracellular ATP via P2Y₂ Purinergic Receptor.

Perera LMB, Sekiguchi A, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Yokoyama Y, Ogino S, Torii R, Hosoi M, Ishikawa O, Motegi SI

The Journal of investigative dermatology 139(4) 890-899 Apr 2019 [Refereed]

Relationship between esophageal motility abnormalities and skin or lung involvements in patients with systemic sclerosis.

Kuribayashi S, Motegi SI, Hara K, Shimoyama Y, Hosaka H, Sekiguchi A, Yamaguchi K, Kawamura O, Hisada T, Ishikawa O, Kusano M, Uraoka T

Journal of gastroenterology Apr 2019 [Refereed]

Clinical value of ¹⁸ F-fluorodeoxyglucose positron emission tomography/computed tomography for interstitial lung disease and myositis in patients with dermatomyositis.

Motegi SI, Fujiwara C, Sekiguchi A, Hara K, Yamaguchi K, Maeno T, Higuchi T, Hirasawa H, Kodaira S, Tomonaga H, Tsushima Y, Ishikawa O

The Journal of dermatology 46(3) 213-218 Mar 2019 [Refereed]

Prevalence and clinical characteristics of overactive bladder in systemic sclerosis.

Motegi S, Sekiguchi A, Sekine Y, Nakayama H, Suzuki K, Ishikawa O

Modern Rheumatology 1-5 Mar 2019 [Refereed]

Cutaneous adult xanthogranuloma with a small portion of BRAF^V ^600E mutated Langerhans cell histiocytosis populations: A case report and the review of published work.

Ishikawa M, Endo Y, Uehara A, Suto M, Yasuda M, Motegi SI, Ishikawa O

The Journal of dermatology 46(2) 161-165 Feb 2019 [Refereed]

Possible contribution of PDGF-BB-induced autophagy in dermatofibrosarcoma protuberans: Autophagy marker Atg5 could be a differential marker between dermatofibrosarcoma protuberans and dermatofibroma.

Motegi S, Fujiwara C, Sekiguchi A, Yamazaki S, Yokoyama Y, Yasuda M, Ishikawa O

Journal of Dermatological Science 93(2) 139-141 Feb 2019 [Refereed]

Demographic and clinical characteristics of spinal calcinosis in systemic sclerosis: Possible association with peripheral angiopathy.

Motegi SI, Sekiguchi A, Yonemoto Y, Mieda T, Chikuda H, Ishikawa O

The Journal of dermatology 46(1) 33-36 Jan 2019 [Refereed]

Inhibitory effect of kaempferol on skin fibrosis in systemic sclerosis by the suppression of oxidative stress

Sekiguchi A, Motegi S, Fujiwara C, Yamazaki S, Inoue Y, Uchiyama A, Akai R, Iwawaki T, Ishikawa O.

Journal of Dermatological Science Aug 2019 [Refereed]

The significance of tumor cells-derived MFG-E8 in tumor growth of angiosarcoma

Fujiwara C, Motegi S, Ohira A, Yamaguchi S, Sekiguchi A, Yasuda M, Nakamura H, Makiguchi T, Yokoo S, Hoshina D, Abe R, Takahashi K, Ishikawa O.

Journal of Dermatological Science Aug 2019 [Refereed]

A case of Birt-Hogg-Dubé syndrome accompanied by colon polyposis and oral papillomatosis.

Motegi SI, Sekiguchi A, Fujiwara C, Yamazaki S, Nakano H, Sawamura D, Ishikawa O

European journal of dermatology : EJD 28(5) 720-721 Oct 2018 [Refereed]

Two cases of chronic oral ulcers effectively treated with systemic corticosteroid therapy: Circumorificial plasmacytosis and traumatic ulcerative granuloma with stromal eosinophilia.

Kuriyama Y, Shimizu A, Toki S, Endo Y, Yasuda M, Motegi SI, Ishikawa O

The Journal of dermatology Oct 2018 [Refereed]

Diffuse erythema with ‘angel wings’ sign in Japanese patients with anti-small ubiquitin-like modifier activating enzyme antibody-associated dermatomyositis

S Inoue, N Okiyama, M Shobo, S-i Motegi, H Hirano, Y Nakagawa, A Saito, Y Nakamura, Y Ishitsuka, Y Fujisawa, R Watanabe, M Fujimoto

British Journal of Dermatology Sep 2018 [Refereed]

Wound, pressure ulcer and burn guidelines - 2: Guidelines for the diagnosis and treatment of pressure ulcers, second edition.

Fujiwara H, Isogai Z, Irisawa R, Otsuka M, Kadono T, Koga M, Hirosaki K, Asai J, Asano Y, Abe M, Amano M, Ikegami R, Ishii T, Isei T, Ito T, Inoue Y, Iwata Y, Omoto Y, Kato H, Kaneko S, Kanoh H, Kawakami T, Kawaguchi M, Kukino R, Kono T, Kodera M, Sakai K, Sakurai E, Sarayama Y, Shintani Y, Tanioka M, Tanizaki H, Tsujita J, Doi N, Nakanishi T, Hashimoto A, Hasegawa M, Hayashi M, Fujita H, Fujimoto M, Maekawa T, Matsuo K, Madokoro N, Motegi SI, Yatsushiro H, Yamasaki O, Yoshino Y, Pavoux AL, Tachibana T, Ihn H

The Journal of dermatology Sep 2018 [Refereed]

Suppressive regulation of MFG-E8 on latent-TGF-β-induced fibrosis via binding to integrin αV: The significance in the pathogenesis of fibrosis in systemic sclerosis

Fujiwara C, Uehara A, Sekiguchi A, Uchiyama A, Yamazaki S, Ogino S, Yokoyama Y, Torii R, Hosoi M, Suto C, Tsunekawa K, Murakami M, Ishikawa O, Motegi S

Arthritis & Rheumatology Sep 2018 [Refereed]

Autoantibody to transcriptional intermediary factor-1β as myositis-specific antibody: clinical correlation with CADM or DM with mild myopathy.

Ueda-Hayakawa I, Hamaguchi Y, Okiyama N, Motegi SI, Yamaoka T, Miyake S, Higashi A, Okamoto H, Takehara K, Fujimoto M

The British journal of dermatology Aug 2018 [Refereed]

Milia-like idiopathic calcinosis cutis and plaque-type syringoma in a girl with Down syndrome.

Motegi S, Sekiguchi A, Fujiwara C, Yamazaki S, Ishikawa O

Journal of Dermatology Aug 2018 [Refereed]

Differential clinical features of patients with clinically amyopathic dermatomyositis who have circulating anti-MDA5 autoantibodies with or without myositis-associated autoantibodies.

Yamaguchi K, Yamaguchi A, Kashiwagi C, Sawada Y, Taguchi K, Umetsu K, Oshima K, Uchida M, Suzuki M, Kono S, Takemura M, Masubuchi H, Kitahara S, Hara K, Maeno T, Motegi SI, Muro Y, Sakairi T, Hisada T, Kurabayashi M

Respiratory medicine 140 1-5 Jul 2018 [Refereed]

Impact of a new simplified disability scoring system for adult patients with localized scleroderma.

Okiyama N, Asano Y, Hamaguchi Y, Jinnin M, Motegi SI, Koizumi H, Hasegawa M, Ishikawa O, Sato S, Takehara K, Yamamoto T, Fujimoto M, Ihn H

The Journal of dermatology 45(4) 431-435 Apr 2018 [Refereed]

Whole-Mount Adult Ear Skin Imaging Reveals Defective Neuro-Vascular Branching Morphogenesis in Obese and Type 2 Diabetic Mouse Models.

Yamazaki T, Li W, Yang L, Li P, Cao H, Motegi SI, Udey MC, Bernhard E, Nakamura T, Mukouyama YS

Scientific reports 8(1) 430 Jan 2018 [Refereed]

A case of Birt-Hogg-Dubé Syndrome accompanied with colon polyposis and oral papillomatosis.

Motegi S, Sekiguchi A, Fujiwara C, Yamazaki S, Nakano H, Sawamura D, Ishikawa O

European Journal of Dermatology 2018 [Refereed]

Multiple extragenital lichen sclerosus successfully treated with narrowband-UVB phototherapy

Motegi S, Sekiguchi A, Fujiwara C, Yamazaki S, Ishikawa O

European Journal of Dermatology 2018 [Refereed]

Possible contribution of autophagy in pyogenic granuloma

Motegi S, Fujiwara C, Yamazaki S, Sekiguchi A, Ishikawa O

Journal of Dermatology 2018 [Refereed]

Therapeutic efficacy and adverse events of hydroxychloroquine administration in Japanese SLE/CLE patients

Kishi C, Motegi S, Yasuda M, Ishikawa O

Journal of Dermatology 2018 [Refereed]

Inhibitory regulation of skin fibrosis in systemic sclerosis by apelin/APJ signaling

Yokoyama Y, Sekiguchi A, Fujiwara C, Uchiyama A, Uehara A, Ogino S, Torii R, Ishikawa O, Motegi S

Arthritis & Rheumatology 2018 [Refereed]

Botulinum toxin B suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model: possible regulation of oxidative and endoplasmic reticulum stress

Sekiguchi A, Motegi S, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Perera B, Nakamura H, Ogino S, Yokoyama Y, Akai R, Iwawaki T, Ishikawa O

Journal of Dermatological Science 2018 [Refereed]

Eosinophilic peripheral arteritis: hypereosinophilia and Burger’s disease-like arterial occlusion and/or juvenile temporal arteritis

Motegi S, Sekiguchi A, Ishibuchi H, Yasuda M, Ishikawa O

Oct 2017 [Refereed]

Complete resolution of facial molluscum contagiosum in a human immunodeficiency virus-infected patient by antiretroviral therapy

Motegi S, Sekiguchi A, Ishikawa O

Journal of Dermatology Sep 2017 [Refereed]

Two cases of sarcoidosis presenting as diffuse facial erythema successfully treated by minocycline

Motegi S, Fujiwara C, Sekiguchi A, Ishikawa O

European Journal of Dermatology Aug 2017 [Refereed]

Efficacy of Botulinum Toxin B Injection for Raynaud's Phenomenon and Digital Ulcers in Patients with Systemic Sclerosis.

Motegi SI, Uehara A, Yamada K, Sekiguchi A, Fujiwara C, Toki S, Date Y, Nakamura T, Ishikawa O

Acta dermato-venereologica Mar 2017 [Refereed]

Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy.

Yanagita T, Murata Y, Tanaka D, Motegi SI, Arai E, Daniwijaya EW, Hazama D, Washio K, Saito Y, Kotani T, Ohnishi H, Oldenborg PA, Garcia NV, Miyasaka M, Ishikawa O, Kanai Y, Komori T, Matozaki T

JCI insight 2(1) e89140 Jan 2017 [Refereed]

Fibroblastic rheumatism: a case of multiple nodules of fingers and hands, contractures of fingers and polyarthritis.

Motegi S, Yamazaki S, Fujiwara C, Sekiguchi A, Ishikawa O.