論文

2020年11月22日

Management guideline for Werner syndrome 2020. 6. Skin ulcers associated with Werner syndrome: Prevention and non-surgical and surgical treatment.

Geriatrics & gerontology international
  • Yoshitaka Kubota
  • Minoru Takemoto
  • Toshibumi Taniguchi
  • Sei-Ichiro Motegi
  • Akira Taniguchi
  • Hironori Nakagami
  • Yoshiro Maezawa
  • Masaya Koshizaka
  • Hisaya Kato
  • Seijiro Mori
  • Kazuhisa Tsukamoto
  • Masafumi Kuzuya
  • Koutaro Yokote
  • 全て表示

21
2
開始ページ
153
終了ページ
159
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/ggi.14096

AIM: To provide guidelines on the diagnosis, treatment, and prevention of skin ulcers in Werner syndrome. METHODS: This article was based on literature from 1996, when WRN was identified as a gene responsible for Werner syndrome, and we evaluated several authentic clinical cases of genetically diagnosed patients. There were 63 patients with Werner syndrome in the Japanese reports retrieved from Medical Online between January 1996 and December 2017. There were 56 patients with Werner syndrome in English reports written by Japanese authors and retrieved from PubMed during the same period. RESULTS: Records on skin ulcers were found in 27 (43%) out of 63 patients and 22 (40%) out of 56 patients from the Japanese and English reports, respectively. The reported ulcers were often located at the distal one-third of the lower legs. There were 8 patients with callosities in the foot in the Japanese reports and 9 patients in the English reports. A skin ulcer in Werner syndrome is generally intractable. Weight-bearing ulcers or callosity should be critically assessed in surgical procedures because they have effects on patient pain and gait. By adopting a recently advanced technique to facilitate wound healing, the cases of ulcers that were difficult to treat and those requiring major operations can be closed with minimally invasive surgery. CONCLUSIONS: Skin ulcers in Werner syndrome are refractory, and they lead to reduced quality of life of patients. A callosity in Werner syndrome is an important therapeutic target for the prevention of ulcers. Geriatr Gerontol Int 2020; ••: ••-••.

リンク情報
DOI
https://doi.org/10.1111/ggi.14096
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33225552
ID情報
  • DOI : 10.1111/ggi.14096
  • PubMed ID : 33225552

エクスポート
BibTeX RIS