2018年5月
Stereoselective nucleophilic addition reactions to cyclic N-acyliminium ions using the indirect cation pool method: Elucidation of stereoselectivity by spectroscopic conformational analysis and DFT calculations
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
- 巻
- 14
- 号
- 開始ページ
- 1192
- 終了ページ
- 1202
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3762/bjoc.14.100
- 出版者・発行元
- BEILSTEIN-INSTITUT
In this study, six-membered N-acyliminium ions were generated by the "indirect cation pool" method and reacted with several nucleophiles. These reactions afforded disubstituted piperidine derivatives with high diastereoselectivities and good to excellent yields. The conformations of the obtained N-acyliminium ions were studied by low temperature NMR analyses and DFT calculations and were found to be consistent with the Steven's hypothesis.
- リンク情報
- ID情報
-
- DOI : 10.3762/bjoc.14.100
- ISSN : 1860-5397
- Web of Science ID : WOS:000433482900001