論文

1999年4月

2-pyridylsilyl group as a multifunctional 'phase tag' for solution phase synthesis

Tetrahedron Letters
  • Jun ichi Yoshida
  • ,
  • Kenichiro Itami
  • ,
  • Koichi Mitsudo
  • ,
  • Seiji Suga

40
17
開始ページ
3403
終了ページ
3406
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S0040-4039(99)00474-8

2-Pyridyldimethylsilyl (2-PyMe2Si) group was found to serve as effective 'phase tag' for acid-base extraction for solution phase synthesis. Acid-base extraction of octyl(2-pyridyl)dimethylsilane gave rise to 98% recovery. The introduction of 2-PyMe2Si group to organic molecules was easily accomplished by Rh catalyzed hydrosilylation of alkenes with 2- PyMe2SiH. The removal of 2-PyMe2Si group was achieved by the oxidation with H2O2/KF (Tamao oxidation). In order to demonstrate the utility of 2- PyMe2Si group as a 'phase tag', a sequential multi-step transformation was conducted. The products of each steps were easily isolated by acid-base extraction, and were sufficiently pure for the direct use in the next step of the sequence.

リンク情報
DOI
https://doi.org/10.1016/S0040-4039(99)00474-8
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0033597302&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=0033597302&origin=inward
ID情報
  • DOI : 10.1016/S0040-4039(99)00474-8
  • ISSN : 0040-4039
  • SCOPUS ID : 0033597302

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