1999年4月
2-pyridylsilyl group as a multifunctional 'phase tag' for solution phase synthesis
Tetrahedron Letters
- ,
- ,
- ,
- 巻
- 40
- 号
- 17
- 開始ページ
- 3403
- 終了ページ
- 3406
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0040-4039(99)00474-8
2-Pyridyldimethylsilyl (2-PyMe2Si) group was found to serve as effective 'phase tag' for acid-base extraction for solution phase synthesis. Acid-base extraction of octyl(2-pyridyl)dimethylsilane gave rise to 98% recovery. The introduction of 2-PyMe2Si group to organic molecules was easily accomplished by Rh catalyzed hydrosilylation of alkenes with 2- PyMe2SiH. The removal of 2-PyMe2Si group was achieved by the oxidation with H2O2/KF (Tamao oxidation). In order to demonstrate the utility of 2- PyMe2Si group as a 'phase tag', a sequential multi-step transformation was conducted. The products of each steps were easily isolated by acid-base extraction, and were sufficiently pure for the direct use in the next step of the sequence.
- リンク情報
- ID情報
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- DOI : 10.1016/S0040-4039(99)00474-8
- ISSN : 0040-4039
- SCOPUS ID : 0033597302