Seiji Hitoshi

Profile Information

Affiliation: Professor, Department of Integrative Physiology, Shiga University of Medical Science

Degree: MD(PhD)

J-GLOBAL ID: 201101091367878012
researchmap Member ID: B000002381

External link: http://www.shiga-med.ac.jp/~hqphysi1/physiol1/english.html

神経内科医として神経疾患、特に脱髄疾患を診療してきた知識と経験を背景に、神経幹細胞の研究を将来的な脳の再生医療に結びつけたい、という目標をもって研究を行っています。最近は、成体脳における神経幹細胞ー神経細胞新生システムやエピジェネティクス修飾と、精神疾患との関係にも興味をもっており、気分障害の病態解明や新規治療薬の開発を目指して研究を進めています。

Research Interests

Research Areas

Research History

Dec, 2011 - Present

Shiga University of Medical Science
Apr, 2007 - Nov, 2011

Department of Molecular Physiology, National Institute for Physiological Sciences
Apr, 2004 - Mar, 2007

Department of Molecular Physiology, National Institute for Physiological Sciences
Sep, 2003 - Mar, 2004

助教授, 岡崎国立共同研究機構生理学研究所
Apr, 2003 - Aug, 2003

The University of Tokyo
Sep, 2001 - Apr, 2003

Faculty of Medicine University Hospital, The University of Tokyo
Oct, 1999 - Sep, 2001

Postdoc, University of Toronto
Apr, 1997 - Sep, 1999

基礎科学特別研究員, 理化学研究所糖遺伝情報研究チ-ム
Jan, 1993 - Mar, 1993

The University of Tokyo
Jun, 1991 - Dec, 1992

神経内科医員, 東京都老人医療センター
Jun, 1990 - May, 1991

神経内科医員, 日本赤十字社

Major Papers

Fut9 Deficiency Causes Abnormal Neural Development in the Mouse Cerebral Cortex and Retina.

Asmaa Abdullah, Yoshitaka Hayashi, Naoko Morimura, Akhilesh Kumar, Kazuhiro Ikenaka, Akira Togayachi, Hisashi Narimatsu, Seiji Hitoshi

Neurochemical Research, 47(9) 2793-2804, Jun 26, 2022 Peer-reviewedCorresponding author
Life-Long Neural Stem Cells Are Fate-Specified at an Early Developmental Stage

Aoi Tanaka, Shohei Ishida, Takahiro Fuchigami, Yoshitaka Hayashi, Anri Kuroda, Kazuhiro Ikenaka, Yugo Fukazawa, Seiji Hitoshi

Cerebral Cortex, 30(12) 6415-6425, Nov 3, 2020 Peer-reviewedCorresponding author
Early Maternal and Social Deprivation Expands Neural Stem Cell Population Size and Reduces Hippocampus/Amygdala-Dependent Fear Memory.

Kenny Anak Daun, Takahiro Fuchigami, Natsu Koyama, Noriko Maruta, Kazuhiro Ikenaka, Seiji Hitoshi

Frontiers in Neuroscience, 14 22-22, 2020 Peer-reviewedCorresponding author
Minocycline Directly Enhances the Self-Renewal of Adult Neural Precursor Cells

Anri Kuroda, Takahiro Fuchigami, Satoshi Fuke, Natsu Koyama, Kazuhiro Ikenaka, Seiji Hitoshi

Neurochemical Research, 43(1) 219-226, Jan 1, 2018 Peer-reviewedCorresponding author
The Dorsoventral Boundary of the Germinal Zone is a Specialized Niche for the Generation of Cortical Oligodendrocytes during a Restricted Temporal Window

Masae Naruse, Yugo Ishino, Akhilesh Kumar, Katsuhiko Ono, Hirohide Takebayashi, Masahiro Yamaguchi, Yasuki Ishizaki, Kazuhiro Ikenaka, Seiji Hitoshi

Cerebral Cortex, 26(6) 2800-2810, Jun, 2016 Peer-reviewedCorresponding author
Mechanisms for Interferon-α-Induced Depression and Neural Stem Cell Dysfunction

Lian-Shun Zheng, Seiji Hitoshi, Naoko Kaneko, Keizo Takao, Tsuyoshi Miyakawa, Yasuhito Tanaka, Hongjing Xia, Ulrich Kalinke, Koutaro Kudo, Shigenobu Kanba …

Stem Cell Reports, 3(1) 73-84, Jul, 2014 Peer-reviewedLead author
Bre1a, a Histone H2B Ubiquitin Ligase, Regulates the Cell Cycle and Differentiation of Neural Precursor Cells

Yugo Ishino, Yoshitaka Hayashi, Masae Naruse, Koichi Tomita, Makoto Sanbo, Takahiro Fuchigami, Ryoji Fujiki, Kenzo Hirose, Yayoi Toyooka, Toshihiko Fujimori …

Journal of Neuroscience, 34(8) 3067-3078, Feb, 2014 Peer-reviewedCorresponding author
The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations.

Akhilesh Kumar, Tomohiro Torii, Yugo Ishino, Daisuke Muraoka, Takeshi Yoshimura, Akira Togayachi, Hisashi Narimatsu, Kazuhiro Ikenaka, Seiji Hitoshi

Journal of Biological Chemistry, 288(40) 28859-68, Oct 4, 2013 Peer-reviewedCorresponding author
Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells

Seiji Hitoshi, Yugo Ishino, Akhilesh Kumar, Salma Jasmine, Kenji F Tanaka, Takeshi Kondo, Shigeaki Kato, Toshihiko Hosoya, Yoshiki Hotta, Kazuhiro Ikenaka

Nature Neuroscience, 14(8) 957-964, Aug, 2011 Peer-reviewedLead authorCorresponding author
Mood stabilizing drugs expand the neural stem cell pool in the adult brain through activation of notch signaling

Mikito Higashi, Noriko Maruta, Alan Bernstein, Kazuhiro Ikenaka, Seiji Hitoshi

Stem Cells, 26(7) 1758-1767, 2008 Peer-reviewedCorresponding author
Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress

Seiji Hitoshi, Noriko Maruta, Mikito Higashi, Akhilesh Kumar, Nobumasa Kato, Kazuhiro Ikenaka

Journal of Neuroscience Research, 85(16) 3574-3585, Dec, 2007 Peer-reviewedLead author
Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling

Seiji Hitoshi, Raewyn M. Seaberg, Cheryl Koscik, Tania Alexson, Susumu Kusunoki, Ichiro Kanazawa, Shoji Tsuji, Derek van der Kooy

Genes & Development, 18(15) 1806-1811, Aug 1, 2004 Peer-reviewedLead authorCorresponding author
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

Seiji Hitoshi, Tania Alexson, Vincent Tropepe, Dorit Donoviel, Andrew J. Elia, Jeffrey S. Nye, Ronald A. Conlon, Tak W. Mak, Alan Bernstein, Derek van der Kooy

Genes & Development, 16(7) 846-858, Apr 1, 2002 Peer-reviewedLead author
Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain

Seiji Hitoshi, Vincent Tropepe, Marc Ekker, Derek van der Kooy

Development, 129(1) 233-244, Jan 1, 2002 Peer-reviewedLead author
Direct Neural Fate Specification from Embryonic Stem Cells

Vincent Tropepe, Seiji Hitoshi, Christian Sirard, Tak W Mak, Janet Rossant, Derek van der Kooy

Neuron, 30(1) 65-78, Apr, 2001 Peer-reviewed

Misc.

Glial cells missing1は脳損傷コア領域のグリア細胞分化と血管新生を誘導する

林義剛, 郷康広, 中林一彦, アブドゥラアスマ, モハマドザキヤ, 等誠司

日本神経化学会大会抄録集(Web), 65th, 2022
Postmortem brain study of major depressive disorders.

林義剛, 等誠司

月刊精神科, 40(4), 2022
バイオマテリアルとしてのカニクイザル不死化Bリンパ球バンクの構築

守村敏史, 伊藤靖, 等誠司, 遠山育夫, 依馬正次

日本獣医学会学術集会講演要旨集, 164th (CD-ROM), 2021
脳における欠失mtDNA蓄積とミトコンドリア機能障害がPolgヘテロ変異マウスの行動異常を誘導する

福家聡, 福家聡, 重吉康史, 中谷仁, 吉田沙織, 向所賢一, 窪田(坂下)美恵, 杉原洋行, 等誠司, 加藤忠史

日本ミトコンドリア学会年会要旨集, 17th, 2017
慢性の痛みはどのように考えられてきたのか？ : 慢性の痛み－何によって生み出されているのか？

小山なつ, 等誠司

医学のあゆみ, 260(2) 131-134, Jan, 2017 Invited
Developmental stage and association factor for glial cell differentiation

68(1) 24-38, 2017
インターフェロンα誘発性カニクイザルうつ病モデルの解析

林義剛, 福家聡, 渕上孝裕, 小山なつ, 楯林義孝, 等誠司

日本生物学的精神医学会(Web), 38th, 2016
Think about Pain : 痛み解説連載企画(第2回)痛みと鎮痛の歴史閑話(2)電気を使った痛みの治療の歴史 : シビレエイとマラー、そしてボルタから

小山なつ, 等誠司

Practice of pain management : 学際的治療による有効な疼痛マネジメントを追求する, 6(4) 214-219, Jan, 2016
N-glycans in the maintenance of stemness

Harumitsu Suzuki, Seiji Hitoshi

Seikagaku, 88(3) 402-405, 2016
痛みと鎮痛の歴史閑話3 ーフロイトと局所麻酔薬と催眠ー

小山なつ, 等誠司

Practice of Pain Management, 7(1) 30-37, 2016
痛みと鎮痛の歴史閑話2 電気を使った痛みの治療の歴史ーシビレエイとマラー、そしてマラーから

小山なつ, 等誠司

Practice of Pain Management, 6(4) 30-35, 2016
Think about Pain : 痛み解説連載企画(第1回)痛みと鎮痛の歴史閑話(1)聖アントニウスの火 St. Anthony's fire

小山なつ, 等誠司

Practice of pain management : 学際的治療による有効な疼痛マネジメントを追求する, 6(3) 160-165, Nov, 2015
Neural stem cells in the pathology and therapy of autoimmune neurological diseases

255(5) 557-562, Oct 31, 2015
胎生期神経前駆細胞に対するGlial cell missingの機能解析

林義剛, 福家聡, 渕上孝裕, 小山なつ, 楯林義孝, 等誠司

日本生化学会大会(Web), 88th, 2015
痛みの概念を歴史から振り返る

小山なつ, 等誠司

最新毉学, 70(8) 1690-1693, 2015
Pain Pathway—Learning from History—

Koyama Natsu, Hitoshi Seiji

Spinal Surgery, 29(3) 287-292, 2015 Invited
痛みと鎮痛の歴史閑話1 聖アントニウスの火―St. Anthony's fire―

小山なつ, 等誠司

Practice of Pain Management, 62(3) 32-37, 2015
大脳皮質オリゴデンドロサイトの起源

成瀬雅衣, 池中一裕, 等誠司

生体の科学, 66(6) 541-545, 2015
霊長類研究で探る大脳皮質の細胞新生と気分の関係

林義剛, 福家聡, 渕上孝裕, 小山なつ, 楯林義孝, 等誠司

日本生物学的精神医学会誌, 2014
免疫性神経疾患における神経幹細胞と再生戦略

等誠司, 清水崇弘, 池中一裕

日本臨床, 71(5) 795-800, May, 2013 Invited

Books and Other Publications

Culturing adult neural stem cells: Application to the study of neurodegenerative and neuropsychiatric pathology in Neurogenesis in the adult brain 2 Clinical implications

Hitoshi S, Kippin T, van der Kooy D (Role: Joint author)

Springer, Jul, 2011 (ISBN: 4431539441)

Presentations

Glioma stem cells as a new therapeutic target.

Hitoshi S

Aug 1, 2020 Invited
Klf4 and 5 regulate the long-lasting neural stem cell population.

Hitoshi S, Kuroda A, Ema M, Fuchigami T

The 6th International Conference on Biology and Pathobiology of KLF/Sp Transcription Factors, Oct 29, 2018 Invited
Revealing the potential of postnatal neural stem cells.

Hitoshi S

2017 International Society for Neurochemistry (ISN)-European Society for Neurochemistry (ESN), Aug 23, 2017 Invited
The Role of KLF proteins in senlf-renewal and differentiation of neural stem cells.

Hitoshi S, Kuroda A, Ema M, Fuchigami T

Science Research Conferences-Federation of American Society for Experimental Biology (SRC-FASEB), Aug 8, 2016 Invited
The role of adult neural stem cell-neurogenesis in the pathogenesis of psychiatric disorders.

Hitoshi S

May 19, 2016 Invited
The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations

S Hitoshi

BMB2015, Dec 2, 2015 Invited
Epigenetics in the maintenance of neural stem cells.

Hitoshi S

25th Meeting of the International Society for Neurochemistry (ISN)/13th APSN/35th ASN, Aug 26, 2015 Invited
神経幹細胞からオリゴデンドロサイト系譜細胞が産生される分子機序

等誠司, 成瀬雅衣, 池中一裕

第120回日本解剖学会･第92回日本生理学会合同大会, Mar 21, 2015 Invited
精神疾患の病態に迫る

等誠司

第57回日本神経化学会, 第36回日本生物学的精神医学会合同年会, Sep 29, 2014 Invited
気分障害の作用機序から考察した双極性障害の病態機序

等誠司

第10回日本うつ病学会, Jul 20, 2013 Invited
Epigenetics underlying the maintenance of neural stem cells.

Hitoshi S

Neuro2013, Jun 22, 2013 Invited
Epigenetic mechanisms underlying the generation and maintenance of mammalian neural stem cells.

Hitoshi S

May 31, 2013 Invited
Epigenetic regulation on the generation and maintenance of neural stem cells.

S Hitoshi

Sep 20, 2012 Invited

Teaching Experience

Professional Memberships

Research Projects

ALSモデルカニクイザルを用いた超早期病態解明および治療戦略構築

科学研究費助成事業挑戦的研究(萌芽), 挑戦的研究(萌芽), 日本学術振興会, Jun, 2022 - Mar, 2025

等誠司, 漆谷真, 小林憲太
Molecular mechanisms of the fate determination of neural stem cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Hitoshi Seiji
Generation of neurodegenerative disease model macaques

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Hitoshi Seiji
α1,3フコース転移酵素Fut10による幹細胞の未分化性維持機構の解明

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2014 - Mar, 2016

等誠司
Analysis of DNA demethylation by Glial cells missing genes

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Hitoshi Seiji, TOMITA KOICHI
Comprehensive Brain Science Network

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2016

Kimura Minoru, Tanji Jun, Takada Masahiko, Nakamura Katsuki, Ohtsuka Toshihisa, Aoki Shigeki, Takao Hidemasa, Shimoji Keigo, Goto Masami, Yoshiura Takashi, Nakata Yasuhiro, Abe Osamu, Masumoto Tomohiko, Tokumaru Aya, Matsumura Akira, Kirino Eiji, Terada Hitoshi, Sato Noriko, Kasai Kiyoto, Hashimoto Ryota, Niwa Shin-ichi, Kato Tadafumi, Suzuki Michio, Shuji Iritani, Nemoto Kiyotaka, Tomita Hiroaki, Murayama Shigeo, Akatsu Hiroyasu, Takao Masaki, Saito Yuko, Bito Haruhiko, Yoshimura Yumiko, Matsuzaki Masanori, Furuta Toshiaki, Okado Haruo, Saito Izumu, Kaibuchi Kozo, Hasegawa Masato, Aiba Atsu, Shiina Nobuyuki, Igarashi Michihiro, Tomoki Nishioka, Watanabe Masahiko, Koike Masato, Sakagami Hiroyuki, Shigemoto Ryuichi, Fukazawa Yugo, Sakimura Kenji, Mori Hisashi, Mishina Masayoshi, Kobayashi Kazuto, Yanagawa Yuchio, Uemura Tadashi, Ishihara Takeshi, Nose Akinao, Iino Yuichi, Miyakawa Tsuyoshi, Takao Keizo, Mushiake Hajime, Katayama Norihiro, Tanaka Tetsu, Inoue Kazuhide, Okabe Shigeo, Kano Masanobu, Fujiyama Fumino, Isa Tadashi, Kageyama Ryoichiro, Fujita Ichiro, Yoshida Akira, Nishikawa Toru, Nukina Nobuyuki, Fukai Tomoki, Iwatsubo Takeshi, Yamamori Tetsuo, Okazawa Hitoshi, Tanaka Keiji, Kakigi Ryusuke, Tsuda Ichiro, Kitazawa Shigeru, Doya Kenji, Takahashi Ryosuke, Ikenaka Kazuhiro, Sobue Gen, Hasegawa Toshikazu, Ota Jun, Saitoe Minoru, Kadomatsu Kenji, Kida Satoshi, Manabe Toshiya, Tomita Taisuke, Iwata Atsushi, Murakami Ikuya, Tsutsui Ken-ichiro, Hanakawa Takashi, Hirai Hirokazu, Mima Tatsuya, Isomura Yoshikazu, Samejima Kazuyuki, Hoshi Eiji, Miyata Mariko, Yuzaki Michisuke, Tanaka Masaki, Fukata Masaki, Suzuki Kyoko, Kuba Hiroshi, Masu Masayuki, Kinoshita Makoto, Sugihara Izumi, Shirane Michiko, Yamamoto Nobuhiko, Nishijo Hisao, Nambu Atsushi, Takumi Toru, Yamashita Toshihide, Sakurai Takeshi, Tamamaki Nobuaki, Hata Yoshio, Harada Akihiro, Ozaki Norio, Sakai Katsuyuki, Kubo Yoshihiro, Nakazawa Takanobu, Tanaka Kenji, Takei Nobuyuki, Hitoshi Seiji, Takahiroa. Kato, Kato Fusao, Shirao Tomoaki, Taira Masato, Okano Hideyuki, Sekino Yuko, Okamoto Yasumasa, KOMATSU Hidehiko, Miyata Takaki, Takahashi Yoshiko, Nishida Shinya, Tominaga Makoto
神経幹細胞の分化開始を決める分子機構の解明

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2013 - Mar, 2015

等誠司
Epigenetic mechanisms regulating the maintenance and differentiation of neural stem cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2012 - 2014

HITOSHI Seiji, IKENAKA Kazuhiro
網羅的N結合型糖鎖解析による新規フコース転移酵素遺伝子およびLeX抗原の機能解明

科学研究費助成事業挑戦的萌芽研究, 挑戦的萌芽研究, 日本学術振興会, 2009 - 2010

等誠司
Roles of adult neurogenesis in mood and emotion

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2009

HITOSHI Seiji, ISA Tadashi, MURAYAMA Shigeo
GlialCellsMissing遺伝子ノックアウトマウスにおけるグリア細胞産生

科学研究費補助金(萌芽研究), 萌芽研究, 文部科学省, 2007 - 2008
神経幹細胞に対する気分安定薬の薬理作用と作用機序の解析

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2006 - 2007

等誠司
Domain mapping of glial origin … Cell biological basis of glial diversity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2004 - 2007

IKENAKA Kazuhiro, ONO Katsuhiko, SEIJI Hitoshi, TAKEBAYASHI Hirohide
ニューロン-グリア相互作用に関与する機能分子の探索

科学研究費補助金(特定領域研究), 特定領域研究, 文部科学省, 2003 - 2007

池中一裕, 小野勝彦, 等誠司, 竹林浩秀, 田中謙二
神経発生における糖鎖発現の生理的意義の解明

科学研究費補助金(萌芽研究), 萌芽研究, 文部科学省, 2005 - 2006

池中一裕, 小野勝彦, 等誠司
胚性幹細胞から未分化神経幹細胞を経て神経幹細胞へ分化する分子機構の解析

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2005 - 2006

等誠司
神経幹細胞に対する気分安定薬の薬理作用と作用機序の解析

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2005 - 2005

等誠司, 丸田伯子
Dynamics of neural stem cells in the adult mammalian brain under stress conditions.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

HITOSHI Seiji, MARUTA Noriko
マウス早期胚における未分化神経幹細胞から神経幹細胞への分化機構の解析

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2004 - 2004

等誠司
実験的自己免疫性脳脊髄炎の病態におけるガングリオシドの意義の検討

科学研究費補助金(特定領域研究), 特定領域研究, 文部科学省, 2003 - 2004

楠進, 等誠司

Education

Apr, 1993 - Mar, 1997

医学系研究科第二臨床医学専攻, 東京大学大学院

Profile Information

Research Interests

Research Areas

Research History

Major Papers

Misc.

Books and Other Publications

Presentations

Teaching Experience

Professional Memberships

Research Projects

Education

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Coauthors