論文

査読有り
2018年7月15日

A Cluster Analysis of Bronchial Asthma Patients with Depressive Symptoms.

Internal medicine (Tokyo, Japan)
  • Yo Seino
  • ,
  • Takashi Hasegawa
  • ,
  • Toshiyuki Koya
  • ,
  • Takuro Sakagami
  • ,
  • Ichiro Mashima
  • ,
  • Natsue Shimizu
  • ,
  • Yoshiyuki Muramatsu
  • ,
  • Kumiko Muramatsu
  • ,
  • Eiichi Suzuki
  • ,
  • Toshiaki Kikuchi

57
14
開始ページ
1967
終了ページ
1975
記述言語
英語
掲載種別
DOI
10.2169/internalmedicine.9073-17

Objective Whether or not depression affects the control or severity of asthma is unclear. We performed a cluster analysis of asthma patients with depressive symptoms to clarify their characteristics. Methods Multiple medical institutions in Niigata Prefecture, Japan, were surveyed in 2014. We recorded the age, disease duration, body mass index (BMI), medications, and surveyed asthma control status and severity, as well as depressive symptoms and adherence to treatment using questionnaires. A hierarchical cluster analysis was performed on the group of patients assessed as having depression. Results Of 2,273 patients, 128 were assessed as being positive for depressive symptoms [DS(+)]. Thirty-three were excluded because of missing data, and the remaining 95 DS[+] patients were classified into 3 clusters (A, B, and C). The patients in cluster A (n=19) were elderly, had severe, poorly controlled asthma, and demonstrated possible adherence barriers; those in cluster B (n=26) were elderly with a low BMI and had no significant adherence barriers but had severe, poorly controlled asthma; and those in cluster C (n=50) were younger, with a high BMI, no significant adherence barriers, well-controlled asthma, and few were severely affected. The scores for depressive symptoms were not significantly different between clusters. Conclusion About half of the patients in the DS[+] group had severe, poorly controlled asthma, and these clusters were able to be distinguished by their Adherence Starts with Knowledge (ASK)-12 score, which reflects adherence barriers. The control status and severity of asthma may also be related to the age, disease duration, and BMI in the DS[+] group.

リンク情報
DOI
https://doi.org/10.2169/internalmedicine.9073-17
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29526967
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096028

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