2020年10月7日
Atypical Dearomative Spirocyclization of β-Naphthols with Diazoacetamides Using a Silver Catalyst
Organic Letters
- ,
- ,
- ,
- ,
- 巻
- 22
- 号
- 20
- 開始ページ
- 8132
- 終了ページ
- 8138
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.orglett.0c03110
© 2020 American Chemical Society. A chemoselective dearomatization of the less reactive benzenoid unit in β-naphthol was developed. Spirocyclization with a reductant constructs a pivotal structure for drug candidates. One-pot oxidative conversion enabled the tandem dearomatization of β-naphthol, producing conjugated tetraenone variants. The potential utility of the product as an F-selective anion sensor was also demonstrated. Theoretical studies revealed the intermediacy of silver-carbenoid species leading to chemoselective spirocyclization over arene cyclopropanation.
- リンク情報
- ID情報
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- DOI : 10.1021/acs.orglett.0c03110
- ISSN : 1523-7060
- eISSN : 1523-7052
- ORCIDのPut Code : 81592826
- PubMed ID : 33026816
- SCOPUS ID : 85093539473